<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13793

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDDQAYNMDVDDLFGDNEHVNITAIPSPPVKGLVKRLDELSASGCCQKIAWSKNGCVAYIAPDGYGVNLRVFSRDAATGKWDLGKDTPIAMPHTQDEFPFVHLSWSHLGNDLAVMDSAGHVLIFSMAIAIDRMEYRRTEISQPEAEMDTVVGLHWLAVLPHEQKNHIAWSATAKGDTWNFQVSSHVFQDAHHPVERQLSLIYLKRHGELKLRFQQTDNSWHEVATAVGPMLSTREPFTHAAFASNNDNTLLLAAYDVVGRLYLYRIETKWNPPPQPKPGHAPKPFEKPEIRVTEITVEENCYPTTSTMMNGESSTGSESRIRIPAQLTHLNFLPVTPEKDDGTLPTIIALFSTPTNIISIDQNQAHQNPYSIMVKWEVHRQKQSQLHPSLDKVTSKKKSVSSVPERDVFLLKRQADMILHSVVLTFSSLWYHMILAFCYSDGTIEFRKRATLEIIAPDFNNPNTEMVTSLSQAGFSFSTLEPAVQVSLSPNHCIAVCMQQDGTTKLRFMEYSYGSLASDDDNDPRHSAAVAALVLQSSTAANQYLSSDDIFAVMGELSEKRKRDFIHLMFQGLNVNIDCDVEEGRSNNGNQGFMLLGRSPTFVKTLSAAHILGLQGSVTRSVTSKVAWMILNIKYITQILTTIARMHIHGSMGEKRDLRPEVVPQLIGICRWIMNFMVYIMDELISLGLELRKPTTSPTPLTRDILEAKIQEMNHPAILILLSSFPRMMMKLWASPLHWVIRSAMAHTQTPQSPEHRRIYQPLHTAVADVPFDYRHFENLLTEAQMLVRNSYKRAQLTDHQRNLAERDLILGRVPDVLLPAARRLLGDSLFNEQQQQGALLDKLDPARIMFFDTTWLGLYGSDHSKEWWATHVVDVCQKMVIRGSGAQSHPSALNTRNRERSDSAAGANGHGGSGAGAGASGSGGHTEGDKKERGRKSQLRKCVRCGAYMEDVTQGMPGYALHHVSWLSGVAKHCVCGNPWMLADEKRRAK
Length991
PositionTail
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.08
Grand average of hydropathy-0.314
Instability index42.97
Isoelectric point6.75
Molecular weight110979.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364149

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.79|      48|     113|      23|      76|       1
---------------------------------------------------------------------------
   23-   76 (77.77/68.88)	TAIPSPPVK.GLVKRLDELSASGCCQK..IAWSkngcvAYIAPD..GYGVNLRVFsRDA
  138-  190 (73.01/48.10)	TEISQPEAEmDTVVGLHWLAVLPHEQKnhIAWS.....ATAKGDtwNFQVSSHVF.QDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.51|      84|     113|     415|     504|       2
---------------------------------------------------------------------------
  415-  504 (133.62/91.21)	ADMILHSVVLTFSSLWYHMILAFCysdGTI.EFRKRATLEIIAPDFN.NPNTEMVTSLS...QAGFSFSTLEPAVQVSLSPNHCIAVcmqQDGTT
  531-  619 (125.89/71.54)	AALVLQSSTAANQYLSSDDIFAVM...GELsEKRKRDFIHLMFQGLNvNIDCDVEEGRSnngNQGFMLLGRSPTFVKTLSAAHILGL...QGSVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.05|      13|      15|     735|     748|       4
---------------------------------------------------------------------------
  735-  748 (21.85/17.04)	SPLHWVIRSAMaHT
  753-  765 (26.20/15.68)	SPEHRRIYQPL.HT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13793 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQSHPSALNTRNRERSDSAAGANGHGGSGAGAGASGSGGHTEGDKKERGRK
887
937










Molecular Recognition Features






MoRF SequenceStartStop




NANANA