<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13789

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVNNNGAEQTNGLTSNNEVEPTKNEIDVPNGTLQNNDEMEQVMHNMVPLRLIIERLVNQAYADLQNLTEVLPGMPTVERKRAILEYSLNTRQQFVKLLVLVKWAVNADKVQECQNIIGFLQKQNEAFARTVDALYGIYTTMSQARVRNYDILTAIDVLTTGTYQRLPTIIRSHYIPLDPMEDNDVAGTLSKLNDLIRVRMICKETLPLPMNKYKIVNGRVVFRVEHEFELYSLTSACCQVSLTLFGAEEDIPWHIISLDILVCSEKSKVATDMDTSLTDYQIRNLIVNAQQKLIPRPPNPQKSSVPEPEEGQEQSTEPNPEESPENLKLPTYPMVRLYDYLHTFCLSMQLEVLYLQALHLAKSRWAENLIVEINQFRTSIKLKYWCKRPPTTWSSMQNSSTQPTALTNCIEISVVNFEDYNPPQSEEDDTEGTSRSEAEDDTPSLKYPKSVLRVRCEGGADTDGKMIDAFEINPGELDVENLLMRIAELHARAVITRFRDILLNSSFVSNRIEFTKDDLEILDEQHIGTSKAQSSTCGLQVRYRQDRYLTLNVDIRTGRVVIGMSDKVMHEGDVKLRALEEKLNENFVKLPSLLLELKYATLIDDVENMARYLGLEPYPILPLRNEDIAKFGTTKSRMLYLQFTQHPSYYLVVSIVENALNFRLISLGSPLSGSHLMTLSSSVQLDLTSLLRHHQISTQVATQGPISSRPSGGNAKLPSKEANELTIDLGLLSKIDSFCRARISFEKLEKQLTGLSIEYKYIQPMPLACHPADFCAQDTANPISQVPFMQIKPRDIPLRNKGADCSEFVVGSLNIRLADWYASGKSTCQVSMETRILSQSIPSIQDADQEAAKRLHFDHESRILSFKYSDFDSCISQFLKDWETVIMVTLLAKQTCPIVNYFDLTSLKASYGKERFSLAVRWKTSKGSGSNQGHYTLALEENLGQIKQRNPHRKLRFCLEDYLNQTKDLKKLINLLNDTLPLLRVLDELQRKRNATDTFGKGLTVIPRHATHIRLQFSTRYVIDIRMSSATRIFISDAAFSFLEPPNTSQANAILPSPTQFAGDQAMMLLSRSHINPQPIPEFGQFIAQVGQALSQQSQYSQDEHAVVIPLQHGFICGMSVSSFVLHELNSFIESIESTAAPTSSEIPTKLPTQNLHSENSIEIV
Length1165
PositionTail
OrganismBasidiobolus meristosporus CBS 931.73
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Entomophthoromycotina> Basidiobolomycetes> Basidiobolales> Basidiobolaceae> Basidiobolus.
Aromaticity0.07
Grand average of hydropathy-0.300
Instability index46.34
Isoelectric point5.70
Molecular weight131764.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13789
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.45|      81|     214|     518|     600|       1
---------------------------------------------------------------------------
  518-  600 (126.34/90.73)	DLEILDE......QHIGTSKAQSSTCGLQVRYRQDRYLTLNV...DIRTGRVVIGMSD.KVMH..EGDVKLRALEEKLNEnFVkLPSLLLELK..YA
  728-  822 (116.11/74.76)	DLGLLSKidsfcrARISFEKLEKQLTGLSIEYKYIQPMPLAChpaDFCAQDTANPISQvPFMQikPRDIPLRNKGADCSE.FV.VGSLNIRLAdwYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.02|      51|     904|      32|     101|       2
---------------------------------------------------------------------------
   49-  101 (73.74/87.72)	LRLIIERLVNQAyADLQNLTEVLPG.MPTVeRKRAILEYSLNTRQQFVKLLVLV
  955- 1006 (80.28/47.60)	LRFCLEDYLNQT.KDLKKLINLLNDtLPLL.RVLDELQRKRNATDTFGKGLTVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.00|      17|      22|     222|     238|       3
---------------------------------------------------------------------------
  222-  238 (31.48/21.52)	FRVEHE..FELYSLTSACC
  245-  263 (26.53/16.95)	FGAEEDipWHIISLDILVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.24|      44|     411|     267|     313|       5
---------------------------------------------------------------------------
  267-  313 (67.61/50.67)	SKVATDMDTSLTDYQIRNLIvnAQQKLIPRPPNPQKSSVPePEEGQE
  681-  724 (73.63/44.82)	SSVQLDLTSLLRHHQISTQV..ATQGPISSRPSGGNAKLP.SKEANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.03|      46|      93|    1009|    1060|       7
---------------------------------------------------------------------------
 1009- 1060 (72.03/54.97)	HATHIRLQFStrYVIDIRMSSatriFISDAAFSFLEPPNTSQA..NAILPS..PTQ
 1105- 1154 (72.00/41.17)	HAVVIPLQHG..FICGMSVSS....FVLHELNSFIESIESTAAptSSEIPTklPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.17|      23|      23|     149|     171|       8
---------------------------------------------------------------------------
  132-  147 (21.82/11.84)	.DALYGI...YTTMSQAR....VR
  149-  171 (39.83/28.28)	YDILTAI.DVLTTGTYQRLPTIIR
  174-  197 (33.52/22.52)	YIPLDPMeDNDVAGTLSKLNDLIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.12|      41|     170|     428|     492|       9
---------------------------------------------------------------------------
  441-  481 (74.25/93.68)	DTPSLK..YPKS..VLRVR...CEGGADTDGKMIDAFEINPGELDVEN
  903-  950 (55.87/24.97)	DLTSLKasYGKErfSLAVRwktSKGSGSNQGHYTLALEENLGQIKQRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.50|      35|     284|     321|     356|      10
---------------------------------------------------------------------------
  321-  356 (59.73/40.09)	EESPENLKLPTYPMVRL.YDYLHTFClSMQLEVLYLQ
  607-  642 (57.77/34.41)	ENMARYLGLEPYPILPLrNEDIAKFG.TTKSRMLYLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13789 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MVNNNGAEQTNGLTSNNEVEPTKNEIDVPNGTLQN
2) RPPNPQKSSVPEPEEGQEQSTEPNPEESPENLK
1
296
35
328










Molecular Recognition Features






MoRF SequenceStartStop




NANANA