Description | Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MEFIKTCNTNAQAIGDFEAVAFQAFSVKRNPTAAASLGDRSPAEDLHAAEAEFRQGQHLVVQDASKSLLWFFRATTADKAGQKPLALPLLKGYDFQAEQSGVMKASELARPPMRNFTFNTPSSTSSSSPSTPGGLKGPGFSSGNVRAAQGTSQSATPLDQHQQHDSYAIYELFTSSVVALISYYLVRDHNATALNYRTFLSKPSVQPDSDEDPPTSHSANVPYCLTNLSVYWTSSGTLVVSVSSVPRPEIRRLSEVESEEAQRDWMGRCVRVAPNGLLAKIVGFESPSEIGVEPLAHRSQRKRVKIGPVEQSIERWKTLVRRWLKWKGYSIADLDDKSSWVKLRMAHLSQVPPASPAPSSPSREVLWPRMLCLFYEELQSTRDGVDVARAPQKERTLEWFETPDSTGFRDPLDVAQQWFMGKSERDQAFEALRKAQKAEEEAAQPKGDNHGLFPSSPLNSRTGAYGDLQAVSGVYPTPPDGVAPGVGLPSSDNSAPPGSGTNTILVPGGSHPAINLSGPQDHPSTDAHQHPAASPENPLPFDQFNSNINGGNDDLFEDLDEDAFGPGNDITDADFSFFDEPDDENVDVDMPDAAAMQDSKPPSQGKPAKENEPSQLPEADIKEELPDPMAALDDALASALHPPNEIDPVVKSEQRAEEPRATEQPPTEKLTSQLTQSDQSSIVAVKYEPSPPLSPRLVQKKLLPSPTDRSVFQTPKHRDSIFDPVSFNRKMSLSDAKYHGGRFSFSIEKPTKIEEPKTVAKRPASLRDLPMLTKLRHAIGMASARATEVKALERADSDISDSSSETSASEEEDPDDVESIGPATILHGIVIPGKRKLPTDGNATPLSTTSFADSFAGDSLEVTGLQTDESCLMWFESNPADWSLTYLPAPAGLPSTLARNDIPTFSPISPSLPDTPTSQPDTPNDLPDEKPLGIKDSIAVAQIITDQIVSATLDILHEGSSPLALSAAERTPCETTVTTVVRKIFPKATDCNVLGLASVQDVFPDLPQQSKGQPRSAPRKINAQADGSASPGHLIYQINSPHIRVRRGDTLWDVLPPALSFWEPLGLAPCNPAKNVVPFCLYPHSHSLTPCLENFLVNIQIAYETCKFGTHARIQTVPEYEGGLVPCRINGHPSTRAAFKVLRETCIQLGKLLAARHAQMREKDDTKVNAFVIYMIDPFDDASALWELCSAFWSLFQAYGQVPSTRPGNDVPPKPDLVLQVVPIKCIASFDVPVILGSSTYVNLAREVYDRCPPSTPSEDKTPLAIYTAPSFQLEESIPRTIPFKLNAEPPQDLLRESSYMHLGYAISLDGTWITVAWTDSCGKSQAVVSYNLGTRSFGEVAKEIWQTTIEILQARRVTWRICIAKSGVMEREELETWVFLASYPTQLNLFITLLTVDTNPPLKFTPAIPSPTAQSTSGTTTQHLSANTPSSTPQTGGVSPDQHGLTPAATPAEPPNDPSSDPDARLVNVTDESWGIILSHRLHNSNSTVDFRPCLISGLLVKRGESYSTSNTTSSAQLPDPERGPIVVGINILWVGAVGSTRAAASPFPPSASGAEGVSPGVVGASTTGGGQERSSTSLTWTPTAQSRATAENLLKEILGQFRALGLLARLKGMRGTRGGTVPWHVVAAKRGVGGLVEALKEKEKDG |
Length | 1648 |
Position | Kinase |
Organism | Clohesyomyces aquaticus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.396 |
Instability index | 50.46 |
Isoelectric point | 5.21 |
Molecular weight | 178441.92 |
Publications |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.
ECO:0000256 RuleBase:RU364134 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13784 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 401.19| 162| 527| 846| 1067| 1 --------------------------------------------------------------------------- 134- 252 (154.88/57.77) GL..KGP.GFSSGNVRAAQGTSQ..SATpLD.QHQQHDSYAIYELFTSSVVALISyYLVRD..HNATALNYRTFLSKPSVQPDSDEDpPTSHSANVPYCLTNLSVYWTSSGTLVVSVSSvPRPEIRR................................................................................... 558- 644 (63.61/23.54) DL.DEDAFG......................................................................................................................pgnditdadfsffdepddenvdvdmpdaaamqDSKPPSQG...KPAKENEPSQLPEADIKEELP.DPmaALDDALASALHPPN 876- 924 (25.76/32.68) ...............................................................................................................................................................ESNPADWSltyLPAPAGLPSTLARNDIPTFSPiSP..SLPDTPTSQPDTPN 925- 1047 (156.93/96.27) DLpDEKPLGIKDSIAVAQIITDQivSAT.LDiLHEGSSPLALSAAERTPCETTVT.TVVRKifPKATDCNVLGLASVQDVFPDLPQQ.SKGQPRSAPRKINAQADGSASPGHLIYQINS.PHIRVRR................................................................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 378.63| 120| 134| 1186| 1319| 2 --------------------------------------------------------------------------- 1189- 1318 (190.22/113.04) CSAFWSLFqAYGQvpSTRPGNDVPPKP.DLVLQVVPIK......CIASFDVPVILGSSTYVNLARevYdrcpPSTPSEDKTPLAIYTAPSFQLEESIPRTIPFKLNAEPPQDLL..RESSYMHLGyAISLDGTWITVAW 1322- 1450 (188.40/86.67) CGKSQAVV.SYNL..GTRSFGEVAKEIwQTTIEILQARrvtwriCIAKSGVMEREELETWVFLAS..Y....PTQLNLFITLLTVDTNPPLKFTPAIPSPTAQSTSGTTTQHLSanTPSSTPQTG.GVSPDQHGLTPAA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 96.49| 30| 125| 660| 691| 3 --------------------------------------------------------------------------- 660- 691 (47.38/35.68) RATEQPPTEKLTSQLtqSDQSSIVAVKYEPSP 785- 814 (49.10/30.46) RATEVKALERADSDI..SDSSSETSASEEEDP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 242.85| 79| 93| 270| 361| 4 --------------------------------------------------------------------------- 270- 357 (112.06/81.55) VrVAPNGLLAKIVGFESPSEiGVEpLAHRSQRKRVK...IGPVEQSIERWKTLVRRWlkWKGYSIADlddkSSWVKLRMAHLSQVPPASPA 365- 446 (130.79/74.83) V.LWPRMLCLFYEELQSTRD.GVD.VARAPQKERTLewfETPDSTGFRDPLDVAQQW..FMGKSERD....QAFEALRKAQKAEEEAAQPK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 74.29| 24| 131| 700| 727| 5 --------------------------------------------------------------------------- 700- 724 (38.78/21.15) KKLLPSPT....DRSVFQTPKHrDSIFDP 729- 756 (35.51/10.37) RKMSLSDAkyhgGRFSFSIEKP.TKIEEP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 50.04| 14| 20| 478| 496| 6 --------------------------------------------------------------------------- 478- 491 (28.86/10.45) PP.....DGVAPGVGLPSS 1550- 1568 (21.17/ 6.93) PPsasgaEGVSPGVVGAST --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 74.65| 22| 22| 72| 93| 7 --------------------------------------------------------------------------- 72- 93 (36.47/24.51) FRATTADKAGQKPLALPLLKGY 95- 116 (38.18/26.07) FQAEQSGVMKASELARPPMRNF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LFEDLDEDAFGPGNDITDADFSFFDE 2) LSPRLVQKKLLPSPTDRSVF 3) SIVAVKYE 4) TKLRH 5) YHGGRF | 555 693 681 773 738 | 580 712 688 777 743 |
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