<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13784

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFIKTCNTNAQAIGDFEAVAFQAFSVKRNPTAAASLGDRSPAEDLHAAEAEFRQGQHLVVQDASKSLLWFFRATTADKAGQKPLALPLLKGYDFQAEQSGVMKASELARPPMRNFTFNTPSSTSSSSPSTPGGLKGPGFSSGNVRAAQGTSQSATPLDQHQQHDSYAIYELFTSSVVALISYYLVRDHNATALNYRTFLSKPSVQPDSDEDPPTSHSANVPYCLTNLSVYWTSSGTLVVSVSSVPRPEIRRLSEVESEEAQRDWMGRCVRVAPNGLLAKIVGFESPSEIGVEPLAHRSQRKRVKIGPVEQSIERWKTLVRRWLKWKGYSIADLDDKSSWVKLRMAHLSQVPPASPAPSSPSREVLWPRMLCLFYEELQSTRDGVDVARAPQKERTLEWFETPDSTGFRDPLDVAQQWFMGKSERDQAFEALRKAQKAEEEAAQPKGDNHGLFPSSPLNSRTGAYGDLQAVSGVYPTPPDGVAPGVGLPSSDNSAPPGSGTNTILVPGGSHPAINLSGPQDHPSTDAHQHPAASPENPLPFDQFNSNINGGNDDLFEDLDEDAFGPGNDITDADFSFFDEPDDENVDVDMPDAAAMQDSKPPSQGKPAKENEPSQLPEADIKEELPDPMAALDDALASALHPPNEIDPVVKSEQRAEEPRATEQPPTEKLTSQLTQSDQSSIVAVKYEPSPPLSPRLVQKKLLPSPTDRSVFQTPKHRDSIFDPVSFNRKMSLSDAKYHGGRFSFSIEKPTKIEEPKTVAKRPASLRDLPMLTKLRHAIGMASARATEVKALERADSDISDSSSETSASEEEDPDDVESIGPATILHGIVIPGKRKLPTDGNATPLSTTSFADSFAGDSLEVTGLQTDESCLMWFESNPADWSLTYLPAPAGLPSTLARNDIPTFSPISPSLPDTPTSQPDTPNDLPDEKPLGIKDSIAVAQIITDQIVSATLDILHEGSSPLALSAAERTPCETTVTTVVRKIFPKATDCNVLGLASVQDVFPDLPQQSKGQPRSAPRKINAQADGSASPGHLIYQINSPHIRVRRGDTLWDVLPPALSFWEPLGLAPCNPAKNVVPFCLYPHSHSLTPCLENFLVNIQIAYETCKFGTHARIQTVPEYEGGLVPCRINGHPSTRAAFKVLRETCIQLGKLLAARHAQMREKDDTKVNAFVIYMIDPFDDASALWELCSAFWSLFQAYGQVPSTRPGNDVPPKPDLVLQVVPIKCIASFDVPVILGSSTYVNLAREVYDRCPPSTPSEDKTPLAIYTAPSFQLEESIPRTIPFKLNAEPPQDLLRESSYMHLGYAISLDGTWITVAWTDSCGKSQAVVSYNLGTRSFGEVAKEIWQTTIEILQARRVTWRICIAKSGVMEREELETWVFLASYPTQLNLFITLLTVDTNPPLKFTPAIPSPTAQSTSGTTTQHLSANTPSSTPQTGGVSPDQHGLTPAATPAEPPNDPSSDPDARLVNVTDESWGIILSHRLHNSNSTVDFRPCLISGLLVKRGESYSTSNTTSSAQLPDPERGPIVVGINILWVGAVGSTRAAASPFPPSASGAEGVSPGVVGASTTGGGQERSSTSLTWTPTAQSRATAENLLKEILGQFRALGLLARLKGMRGTRGGTVPWHVVAAKRGVGGLVEALKEKEKDG
Length1648
PositionKinase
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.07
Grand average of hydropathy-0.396
Instability index50.46
Isoelectric point5.21
Molecular weight178441.92
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     401.19|     162|     527|     846|    1067|       1
---------------------------------------------------------------------------
  134-  252 (154.88/57.77)	GL..KGP.GFSSGNVRAAQGTSQ..SATpLD.QHQQHDSYAIYELFTSSVVALISyYLVRD..HNATALNYRTFLSKPSVQPDSDEDpPTSHSANVPYCLTNLSVYWTSSGTLVVSVSSvPRPEIRR...................................................................................
  558-  644 (63.61/23.54)	DL.DEDAFG......................................................................................................................pgnditdadfsffdepddenvdvdmpdaaamqDSKPPSQG...KPAKENEPSQLPEADIKEELP.DPmaALDDALASALHPPN
  876-  924 (25.76/32.68)	...............................................................................................................................................................ESNPADWSltyLPAPAGLPSTLARNDIPTFSPiSP..SLPDTPTSQPDTPN
  925- 1047 (156.93/96.27)	DLpDEKPLGIKDSIAVAQIITDQivSAT.LDiLHEGSSPLALSAAERTPCETTVT.TVVRKifPKATDCNVLGLASVQDVFPDLPQQ.SKGQPRSAPRKINAQADGSASPGHLIYQINS.PHIRVRR...................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     378.63|     120|     134|    1186|    1319|       2
---------------------------------------------------------------------------
 1189- 1318 (190.22/113.04)	CSAFWSLFqAYGQvpSTRPGNDVPPKP.DLVLQVVPIK......CIASFDVPVILGSSTYVNLARevYdrcpPSTPSEDKTPLAIYTAPSFQLEESIPRTIPFKLNAEPPQDLL..RESSYMHLGyAISLDGTWITVAW
 1322- 1450 (188.40/86.67)	CGKSQAVV.SYNL..GTRSFGEVAKEIwQTTIEILQARrvtwriCIAKSGVMEREELETWVFLAS..Y....PTQLNLFITLLTVDTNPPLKFTPAIPSPTAQSTSGTTTQHLSanTPSSTPQTG.GVSPDQHGLTPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.49|      30|     125|     660|     691|       3
---------------------------------------------------------------------------
  660-  691 (47.38/35.68)	RATEQPPTEKLTSQLtqSDQSSIVAVKYEPSP
  785-  814 (49.10/30.46)	RATEVKALERADSDI..SDSSSETSASEEEDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.85|      79|      93|     270|     361|       4
---------------------------------------------------------------------------
  270-  357 (112.06/81.55)	VrVAPNGLLAKIVGFESPSEiGVEpLAHRSQRKRVK...IGPVEQSIERWKTLVRRWlkWKGYSIADlddkSSWVKLRMAHLSQVPPASPA
  365-  446 (130.79/74.83)	V.LWPRMLCLFYEELQSTRD.GVD.VARAPQKERTLewfETPDSTGFRDPLDVAQQW..FMGKSERD....QAFEALRKAQKAEEEAAQPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.29|      24|     131|     700|     727|       5
---------------------------------------------------------------------------
  700-  724 (38.78/21.15)	KKLLPSPT....DRSVFQTPKHrDSIFDP
  729-  756 (35.51/10.37)	RKMSLSDAkyhgGRFSFSIEKP.TKIEEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.04|      14|      20|     478|     496|       6
---------------------------------------------------------------------------
  478-  491 (28.86/10.45)	PP.....DGVAPGVGLPSS
 1550- 1568 (21.17/ 6.93)	PPsasgaEGVSPGVVGAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.65|      22|      22|      72|      93|       7
---------------------------------------------------------------------------
   72-   93 (36.47/24.51)	FRATTADKAGQKPLALPLLKGY
   95-  116 (38.18/26.07)	FQAEQSGVMKASELARPPMRNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13784 with Med13 domain of Kingdom Fungi
Unable to open file!