Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MAQPPPQQPDDEPINSSFFPLPPPFYKQFTTENQKRLQDFKEAEGIYGEADTSPSLSADQILKLPPELRFLVPPEPPAEDNEFRVFGETSLINKAAPTLPDWGYEQLYPSPPTPAPGEDPSIQSEWSLNRAEYLQRLIRSILLKFLELLGVMSRDPTKWRDAMTDIGTMGANMHALINEYREHQMRETLILLMEDQLDKKRAEVDGVGKMKQKVEETLANFAKNVPRKLDNGESEDDTTSSPEVKRKEIQRYMWQAMDEILGQ |
Length | 263 |
Position | Middle |
Organism | Clohesyomyces aquaticus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.760 |
Instability index | 60.41 |
Isoelectric point | 4.70 |
Molecular weight | 30106.66 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060 ECO:0000256 ARBA:ARBA00003669 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13776 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 149.76| 35| 44| 39| 82| 1 --------------------------------------------------------------------------- 8- 39 (42.84/21.08) ...Q.......PDDEPINSS..FFPLPPPFykQFTTENQK.RLQD 46- 80 (63.83/24.69) IYGE.......ADTSPSLSADQILKLPPEL..RFLVPPEP.PAED 85- 119 (43.09/12.17) VFGEtslinkaAPTLPDWGYEQ...LYPS.......PPTPaPGED --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.04| 17| 44| 200| 218| 2 --------------------------------------------------------------------------- 200- 218 (23.32/24.25) KRAEVDGVgkMKQKVEETL 245- 261 (31.73/24.06) KRKEIQRY..MWQAMDEIL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DWGYEQLY 2) PINSSFFPLPPPFYKQFTTENQKRLQDFKEAEGIY 3) YMWQAMDEIL | 101 13 252 | 108 47 261 |
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