<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13776

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAQPPPQQPDDEPINSSFFPLPPPFYKQFTTENQKRLQDFKEAEGIYGEADTSPSLSADQILKLPPELRFLVPPEPPAEDNEFRVFGETSLINKAAPTLPDWGYEQLYPSPPTPAPGEDPSIQSEWSLNRAEYLQRLIRSILLKFLELLGVMSRDPTKWRDAMTDIGTMGANMHALINEYREHQMRETLILLMEDQLDKKRAEVDGVGKMKQKVEETLANFAKNVPRKLDNGESEDDTTSSPEVKRKEIQRYMWQAMDEILGQ
Length263
PositionMiddle
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.08
Grand average of hydropathy-0.760
Instability index60.41
Isoelectric point4.70
Molecular weight30106.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.76|      35|      44|      39|      82|       1
---------------------------------------------------------------------------
    8-   39 (42.84/21.08)	...Q.......PDDEPINSS..FFPLPPPFykQFTTENQK.RLQD
   46-   80 (63.83/24.69)	IYGE.......ADTSPSLSADQILKLPPEL..RFLVPPEP.PAED
   85-  119 (43.09/12.17)	VFGEtslinkaAPTLPDWGYEQ...LYPS.......PPTPaPGED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.04|      17|      44|     200|     218|       2
---------------------------------------------------------------------------
  200-  218 (23.32/24.25)	KRAEVDGVgkMKQKVEETL
  245-  261 (31.73/24.06)	KRKEIQRY..MWQAMDEIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13776 with Med7 domain of Kingdom Fungi
Unable to open file!