<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13775

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRQTPIDMVAENGLSSDLNTFPGMLDMDPMMMDTMMMSSYGYSDLDNMMVTDDDFNFFDEPKLPTQPTSNNMMMSTGFDTLDLFNNNPNPPAVPLVNHDPSIEPNCEVKASDSPALLIKDESISADVAITPTLACKTPIGEAAENAAEPISASEPVVKREPMEKSDVLVVDDISYESYDPHLPPDYLPIKGINFDVNKYREGGRFGFRPCRRVRMRRTIYTANFHPRIRRLAYLKAKKKTLVKAGVNSMSNYQIGAGVKNPTDPQPLTVSDSSSSGSSSDSSSSEDESSDEGAISSDDDGGIPVKSYRTVNSARYMMLMDRFQPRANELLSGLNYPKNGKSEDMKFNLNWSLIFGILEENEPRGQTTLVATPNEFRYALSDGLVLNKFQYLLAVERLCQQATLGNYPFGGGIIDFTSNGGEVIDGESTMLIAERYNHISRTLSKDLSKHNTSSEALPDSVLRAVPFLKKVLGGMFTYTNETSQQEMLALRGPLSVQQYLGLYDVHQTQAKYGKYQVKKRKSQEPVLDPLTSPDVIVKHGGECIQASPVILRFWEKMNLEPYGGKKKISWFTIFPEGPAMERSAQWFFTQLGVIYEASSLGRHYPGHLDGLRGGMISAPFSDGPGNRRLSGYLAACRNLGHGLKLNGPQDSPFIVIYLVNPFSEPSSYFELCHIFNELAAQCSGVPGLIDQLVLQIIPAEHILRASSFGGYQRFGLKEVAFSVYNRCRQYLNRPVNPMANPAAVPKTRVFLPAYTLAKITPPTVNYSFKPIVNTRHTLMDRERDLHVAYSFSFDQKWMFAVWTDGQGGLLEHATYELADRKSFSAALRRLWQTTCGMISDNGMIWTVHIGRLGLIPHFELTGKNSSEQNLV
Length870
PositionKinase
OrganismBasidiobolus meristosporus CBS 931.73
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Entomophthoromycotina> Basidiobolomycetes> Basidiobolales> Basidiobolaceae> Basidiobolus.
Aromaticity0.09
Grand average of hydropathy-0.352
Instability index40.98
Isoelectric point5.93
Molecular weight96931.03
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13775
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.21|      27|      36|      17|      46|       1
---------------------------------------------------------------------------
   17-   46 (41.61/36.93)	DLNTF..PgMLDMDPMMmDTMMMSSyGYSDLD
   54-   82 (49.60/28.15)	DFNFFdeP.KLPTQPTS.NNMMMST.GFDTLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.19|      18|      36|     473|     493|       2
---------------------------------------------------------------------------
  473-  493 (27.81/27.33)	GMFTYTNETSQQEMLalrGPL
  512-  529 (31.38/21.29)	GKYQVKKRKSQEPVL...DPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.26|      32|      37|     365|     396|       4
---------------------------------------------------------------------------
  365-  396 (52.82/36.17)	QTTLVATP...NEFRYALSDGLVLNKFQYLLAVER
  400-  434 (49.45/33.38)	QATLGNYPfggGIIDFTSNGGEVIDGESTMLIAER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13775 with Med13 domain of Kingdom Fungi
Unable to open file!