<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13757

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAESSAKRIKLAIEVADENVIKDITDDGEEILEQELTNSEKLDRITSRINFEALLDSKTDNNKDLEKANNENQNIEKINTEPNNNQTPAQPLERIKFNLYFAQQEIELSLDIINRLIMTSTANGRKRVHLENNRIQAAAKSKGILNQPNAQTPQTPGTQPRKTESNIRLSYINKPKLQLKQQIEECQLKLSAKKEHLRYASKVLLEEHENLLKLLDISQAFYNEQAFTLRRNNWVIQSKNRGGMFQKNQKLLYIDYSYKHAGSKFKEMGIAQIKQNPHLTSVNNKINNINNNINNNINNININNTIINNINNINNISNINNNNNNSNNNNINNNNKDEEDSISNEQKIKLLLPHKKKKVVTVEIASLSSPSTHKDVWVTWDTEDIDNDILRQLLESQITIFHNELYNRIINDAQNSYLERKVKFSENMITIPLNNDKVLIFKIHTKTDDKESADIKHLSHKELSEAFLELFLQQKLRNCHKKNIQKNNFFISNIVETQDQNINILSPSVSTISKSNNNFNNNNNNINNKTDAILNKKSETEKSKSNILKDNFVEQTYELILYKECIEYIKKNLDHFIKTLITGKIPVTVRFEKIFNDKAENTLENETQILINFFNNYPVKFGIKFPTKVVFYLNRQQDKNGIINCHEVKNGFIKFLLQELKVICLKIICQEAKNSGITGNEKWEVDDIVGKYLKGIINFQDSIGVFEVITHSNIEPLELSFDIKCQFNKKTTNHTIKLNNNNNNNNRTKDNLNQIKSGINYFPLFINEIQKIFVYDIITCI
Length781
PositionHead
OrganismAnaeromyces robustus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Anaeromyces.
Aromaticity0.07
Grand average of hydropathy-0.690
Instability index42.09
Isoelectric point8.74
Molecular weight90474.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13757
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.34|      28|      28|     282|     309|       1
---------------------------------------------------------------------------
  270-  296 (45.49/12.82)	IAQIK.QNPHLTSVN..NKINNINNNINNN
  297-  325 (45.43/12.79)	INNININNTIINNINniNNISNINNN.NNN
  473-  498 (31.02/ 6.54)	..QQKLRNCHKKNIQ..KNNFFISNIVETQ
  499-  525 (40.40/10.61)	DQNINILSPSVSTIS..KSNNNFNNN.NNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.53|      12|      21|      50|      62|       2
---------------------------------------------------------------------------
   50-   62 (14.64/ 7.26)	NFEAlLDSKTDNN
   74-   85 (20.89/ 7.68)	NIEK.INTEPNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.91|      22|      27|     605|     631|       4
---------------------------------------------------------------------------
  605-  630 (35.89/30.06)	NETQ....ILinffNNYPVKFG.IKF...PTKVV
  634-  663 (26.02/ 8.27)	NRQQdkngII....NCHEVKNGfIKFllqELKVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.28|      27|      30|     145|     174|       8
---------------------------------------------------------------------------
   86-  115 (22.57/ 9.11)	......QTPAQPLERIKfnlyfaQQEIELSLDIINR
  118-  136 (20.42/ 8.37)	M......TSTANGRKRV......HLENN.RIQ....
  145-  174 (40.78/32.93)	LNQpnaQTPQTPGTQPR......KTESNIRLSYINK
  179-  202 (32.51/17.76)	LKQ......QIEECQLK......LSAKKEHLRYASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.10|      20|      22|     385|     405|      10
---------------------------------------------------------------------------
  385-  404 (35.21/20.25)	IDNDILRQLLESQ.......ITI.FHNE
  409-  436 (22.89/ 6.90)	IINDAQNSYLERKvkfsenmITIpLNND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13757 with Med17 domain of Kingdom Fungi
Unable to open file!