<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13756

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNSFMLEDNSVTNIFSLKGVSKIKWKRYYYIYKNDVDRNISNSFLPLESGLLKDPLISSYLHLVSNGVLCIWINGQYNNDDEEGKPTKLFSKSNNLKLNDLMDISKSNDVKKNLISDSKSICKELWIFQYDNEPDIDYKEVEQLIELENGEFNFDTLNTLYVQDSNYEFIEYHLFIKAIYNLLERNFYKHGIFRLGDHFVFLELPKNNSIFMMDTTDNSQSLLSCQIIFTYTSSNLLLQPVIRQHQFLRPLDIHDINKANQNLKNIKNNKNDSDNDNKTKSNIGINQTSVNCHSNILVLLSPHGIPAYLYSSEIQYSYEIDFILSEWSKCFGIPINKLYYHDSNYKIPLVVTVYIPELDCYINYPSKCIFIVDSKNSYNISRKLCYNPRIYHQFNEFIWRDQSIQDDTLIFSEFNNSIKYKNNDIINQVDNINSNKSSNNLVDIKLEINDEEIKANNSRTKNITKNIKDIDFFNFINPEKKILTELVKEEKTINEIQAEIARNINNNNNNNNINNNNNNNNNNNNNNNNNNNNINSNSNSKNNNNLNSSNNNNKVNSPYNNSQIINLKNNKLPPNVINTPNKATKVKEEKKRKNQTDNKKTKKEKKETTEVKIEKPITVENNTQVEDNYGLPMFNDNNFDDFGDWETGIEITDKDFDFFDDKPNASNDFGMDDFFSSSIPDKDSNKQSSLNFSSQDTLITDIKMEEQIETKNSLPSTPATQDVGTPLSINGNKTINSIQNSPDPASMSPINNMMSPQVTIPNDLIKHSPSTISSPLVNNVSQNSVSSLSNEIKSSNNISINTNVNANIKSENIIINNNNNNNNNNDNNNNNNNNNDNDSNNNDNNNNNNNNNNDNDNNNYNNNNNKNNDDDKNNNGINNDNSKDENEISLSKDINNENNNENNIDSNNINNINNNDNNNSSVINETSTNDDDITIPHEWEFKNSNQTYIENLIEKYHKGKWSYEPKLSNYITSYKRKRISKKNLYRIILSKKIKYREDIMINDKSKKDSEIKKEDMKKKKIKEEDINGKLNKRIKIEDINETETVNENKENENANINNHSLTDVNNNIINIDFGSAWKMLNITKYNIINDIIEKNLTELSLEQNLSYNSIIINNNNNYRNELDKISQRIFIDQYTGSLSSWNKSVSNSLSAISLTKENELYDEYIIPSLASKALNQLQIIFEDLFGNDNESKFNSFIEGPLTIKQLYDSEHSQHAKYGKYQVKKKTKKNIDYVLEKLSSPDIIVGNNNEWIKLNSTSLRFWDKIGVLPYSGKKNISWFALCPTMKELNGEPNMNSDLINIVREWFQNLSYIYESSNFGSHTSGNLNSINGIIPCLLDEHNNISNIDNILNSYERAISYFASMMGENIHGIIEEGEATTMSDIDECLNNDQRYIVLYLLNPFSSSDKSFINDNQVKLINYKLCQIFVNSFLYKLSLSTRLSIEKLKSKIILQIIPLDLIANSCSFDGYIIIGLKDLVFTLYSKCRKLLQKNININNTEYIIPNNLYQPAFILSQIAIPIPHFTFKRFSRKNQLKNRINIMEPDRILHISYVYVDDRIVACMTDQVGELFDIIIVDDNNERLISISQSDYDKYTKQQILFIKIWEKAMKLILFGCNFYWRIAIIKIGHVLQNEINDWEFISSKYLEKLQHHYNHPSLKVINNLNEQIYSVSILGIYKNSSFQIFKEKIKSNSSSLNPLTRKDSERISSSSLQNNQKSASNNSLKNDININEFNDITINLSNSCYTYIHSVQRSPSFPSNPEIIWPLISSKYDNMKDNNLALPLSIGWMIYTPSMESKQVGINTKNFEILLLSHQHSRTLKSNKTCFPTWNPILPTTPMSMPNSPSSSSTSVSKGINGNTNPPTLTKSNSISMKDINSPLSMMSSSSTLSLNNNNNGSSIPFNVILSDLIKQYFSLSFLEIHWSNLINTANGCASDDLRLPIHISSANRISKILKGFHF
Length1956
PositionKinase
OrganismAnaeromyces robustus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Anaeromyces.
Aromaticity0.09
Grand average of hydropathy-0.700
Instability index40.13
Isoelectric point5.78
Molecular weight225031.55
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13756
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1229.46|     296|     299|     407|     705|       1
---------------------------------------------------------------------------
   54-  308 (223.98/48.63)	...............................................................................................................DPLISSYLhlvSNGVlciwingQY..NNDDE.....EGKPTKLFS..KS.........NN.....LKLNDlMDISK............................SNDVKKNLisdSKSIcKELWI...FQYDNePDidyK.EV.EQLIELENgefnfdTLNTlyVQDSNYEFIEYHLFIKAI..YNLLERNfykhgifrlgDHFVFLELPKNNSIFMMDTTDNSQSLLSC....QIIFTYTSSnlllQPVIRQHQFLRPLDIHDINKANQnLKNIKNNKNDSDNdNKTKSNiGINQTSVNCHSNILV.....LLSPHGIPAY
  312-  634 (451.98/108.08)	SEIQYSyeiDFilSEWSKcfGI...PI..NK.L.YYHD....SN.YKIPLVVTVYIPELDCY....INYPSKCIFIVDSKNSynisrklcynpriyhqfnefiwrdqsiqdDTLIFSEF...NNSI.......KY..KNNDI.....INQVDNINSNKSS.........NNLVDIKLEIND.EEIKA............................NNSRTKNI...TKNI.KDIDF...FNFIN.PE...K.KILTELVKEEK......TINE..IQAEIARNINNNNNNNNI..NNNNNNN..........NNNNNNNNNNNNNINSNSNSKNNNNLNSSNNNNKVNSPYNNS....QIINLKNNKLPPNVINTPNKATK.VKEEKKRKNQTDN.KKTKKE.KKETTEVKIEKPITVENNTqVEDNYGLPMF
  635-  909 (386.95/92.34)	NDNNFD...DF..GDWET..GI...EIT.DKDFDFFDDkpNASNDFGMDDFFSSSIPDKDSNKQSSLNFSSQDTLITDIKME............................eQI....ET...KNSL.......PStpATQDVgtplsINGNKTINSIQNSpdpasmspiNNMMSPQVTIPN.DLIKH............................SPS..........TI.SS.PL...VN..N.VS...Q.NSVSSLSNEIK......SSNN..I..SINTNVNANIKSENIiiNNNNNNN..........NNNDNNNNNNNNNDNDSNNNDNNNN.NNNNNNDNDNNNYNN.....N..NNKNNDD.....D.KN............NNGINN.DNSKDE.....NEISLSKDINNENNN..ENNIDSNNI
  915- 1121 (166.55/34.20)	NDNNNS...SV..IN.ET..STnddDITiPHEWEF.....KNSNQTYIENLIEKYHKGKWSYEPKLSNY......ITSYK.R........................kriskKNLYRIIL...SKKI.......KY..REDIM.....INDKSKKDSEIKK.........EDMKKKK..IKE.EDINGklnkrikiedinetetvnenkenenaniNNHSLTDV...NNNI.INIDFgsaWKMLN.IT...KyNIINDII..EK......NLTE..LSLEQNLSYNSIIINNNN..NYRNE.....................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     217.82|      44|      44|    1749|    1792|       2
---------------------------------------------------------------------------
 1708- 1746 (56.23/23.66)	SLQNNQ.KSAS........NNSLKNDININEF.......NDITINLSNS.CY.TYIH
 1747- 1790 (77.09/35.84)	SVQRSP.SFPS........NPEIIWPLISSKYD.N.MKDNNLALPLSIG.WM.IYTP
 1791- 1829 (32.30/ 9.69)	SME.......SkqvgintkNFEIL..LLSHQHS.RtLKSNKTCFP....tW....NP
 1830- 1876 (52.19/21.30)	ILPTTPmSMPN........SPSSSSTSVSKGINgN.TNPPTLTKSNSIS.MKdINSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.85|      41|      44|    1452|    1495|       3
---------------------------------------------------------------------------
 1452- 1481 (41.76/19.12)	...............IIPLDLIAN.SCSF.DGYIIIGLKDLVFTLYS
 1484- 1527 (57.71/38.04)	RKLLQKNiNINNteyIIPNNLYQP.AFIL.SQ.IAIPIPHFTFKRFS
 1528- 1568 (53.39/24.55)	RKNQLKN.RINI...MEP.DRILHiSYVYvDDRIVACMTDQVGELF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     224.46|      48|      48|    1295|    1342|       4
---------------------------------------------------------------------------
 1174- 1217 (40.90/17.39)	.......LNQLQIIFE.DLFGNDNESKFN.....................................SfIEGplTIKQLYDsEHSQHAKY
 1220- 1297 (41.67/17.88)	YQVKKKTKKNIDYVLEKLSSPDIIVGNNNewiklnstslrfwdkigvlpysgkkniswfalcptmkE.LNG..........EPNMNSDL
 1298- 1345 (83.77/44.72)	INIVREWFQNLSYIYESSNFGSHTSGNLN.....................................S.ING..IIPCLLD.EHNNISNI
 1346- 1382 (58.12/28.37)	DNILNSYERAISY......FASMMGEN.........................................IHG..IIE..EG.EATTMSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.17|      12|      15|    1655|    1666|       5
---------------------------------------------------------------------------
 1655- 1666 (20.07/11.09)	LKVINNLNEQIY
 1671- 1682 (21.10/12.19)	LGIYKNSSFQIF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13756 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGMDDFFSSSIPDKDSNKQSSLNFSSQDTLITDIKMEEQIETKNSLPSTPATQDVGTPLSINGNKTINSIQNSPDPASMSPINNMMSPQVTIPNDLIKHSPSTISSPLVNNVSQNSVSSLSNEIKSSNNISINTNVNANIKSENIIINNNNNNNNNNDNNNNNNNNNDNDSNNNDNNNNNNNNNNDNDNNNYNNNNNKNNDDDKNNNGINNDNSKDENEISLSKDINNENNNENNIDSNNINNINNNDNNNSSVINETSTNDDDITIPHEWEF
2) NEIQAEIARNINNNNNNNNINNNNNNNNNNNNNNNNNNNNINSNSNSKNNNNLNSSNNNNKVNSPYNNSQIINLKNNKLPPNVINTPNKATKVKEEKKRKNQTDNKKTKKEKKETTEVKIEKPITVENNTQVEDNYGLPMFNDN
3) PMSMPNSPSSSSTSVSKGINGNTNPPTLTKSNS
669
494
1835
941
637
1867










Molecular Recognition Features






MoRF SequenceStartStop




1) GIEITDKDFDFFD
2) WKRYYYIYK
648
25
660
33