<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13751

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDDNINDLNINSIQNDFDLLPKNEANLIPLKLIYERVIQNYYSELQNLSETLPTKSNEQKKVEIFKLVQNLNQSAVKLLVLIRWAKQSKEVLKCKNICDFLEEQNSYFRGAADALFTVHQEMNLARIPNFDIPTAVDVLTTGTYSRLPTIIKEPISLPPLKNEEIKDAIEKLEDVTRLRLLCEEIIPKPMKKNYVIENGSVRFTVENEFEVTLKLEGKQQDNWKLLDLKIFVKPDDNLNHDLIMPLQEYQLENIKINAQNSIRTDITNPNSNLPSSNSLNPTQNSTSNQITNTSTNNNNNNNNTSEGDKPTKPKKIWPLIEIYRYLHSFCLSMHLEIFSLQVDYLIKTRWANQLRYNISPDKKTLQIFYWIENNSGSKYDIKSKEKKKANVLELSITSAEDVIVFYTNKEHDEYETNNSIIAKSLIYEYEQYIQSNLSIKCYQLLEDGTKKELVDPSTSSKIKFNINSQKLNIEKILERVTEIHAFSILYELRNILIGKSNSKIAIHKCNCKDIIEKNFYNSKTSDNEKEKQQPELIVCYRINHYVKITVDERTGRIVITEYNESGTDNINSFIQEKIKIVEEQINKDLSNAVDDLISLRNLTIINEIELLSIYLGLEPSKKLLITQEELRRLMNSNELFQSQNIIYLRYPNYPNYYIIIYIDSEEINSNVKHKHDVSYFKVWLVSTQKKNSSGFLEFTLFMNLDISQLIENEDNYNNDIENDDFHHFRKRRCIEEPSVWDKTKNLTLDLEILSKIEAVCRYKIAYSLLTTQLKNLHIPYYFVSIKSNNVIDYDSPLSIFDLIIKIRVKDIIPDVIRKCVLGDYILKLNNDLYITATGNTLNKDNNVAPFDKFSIKNSIKGISRGIEVVAKLQVKPGELPINEDFSIGDINFSVKTKVLTFTYSKINNCIYKILNIWKGLLILRIIASQAYSNKDILKNNEMTIDKINLLKTKILFYEKNFVEFALNTSLDNSNSNGINIIFGVKGDNKTSIFYEEKQFLIEDFFKDYNVINFLLKLKTKYVLFKNINLIKKSREEMNSPLTIVKESLNRIKLTYNDQYTIEIGQCTDNLIIILYSESNEKKIIMNTTNSSSTTNKINHHSNIIPQFQSFIDQVIKLNSSSNINGTSLGSTLMSSSTLNSSSSSIAKIEDNPTTATPTTTTTNNNNNNNNNNLKNENEDYVCLKIPNGVIFDIYYIDKVMENFNKLMNSVTYMDWLNDELNRIEQNKTTNKAIINYSKDLQNPLLLTYTNDHIELILTYVYVDDKWTMSLKILSEKADCEVLINKILKLKNPIMGFKDITQLMLLPPDIAKEVLSMINKEKEKQMNGTTSEICLTVPEGLPDYLPNVGESAIFTDVSNNRIGLLCNITYTNPQDNNRRTIVIPFLYNWESKFFCEWNANPELSKLKTNEECKTWIKNQSDPANSVSKLNVLLIRISVIIEKRNEKEKIKFACTTLSSMNTDNYKDIDIKNNM
Length1474
PositionTail
OrganismAnaeromyces robustus
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Anaeromyces.
Aromaticity0.09
Grand average of hydropathy-0.425
Instability index39.07
Isoelectric point6.09
Molecular weight170592.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13751
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.15|      11|      37|     953|     963|       1
---------------------------------------------------------------------------
  953-  963 (19.76/10.59)	KTKILFYEKNF
  991- 1001 (19.39/10.24)	KTSIFYEEKQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.17|      50|     101|     412|     470|       3
---------------------------------------------------------------------------
   18-   41 (20.86/ 6.54)	DFDLLPKNEaNLIPLKLI..YERVIQ..............................
  412-  466 (72.56/47.42)	EHDEYETNN.SIIAKSLIyeYEQYIQsNLSIKCYQllEDGTKKELVDPSTSSKIKF
 1071- 1097 (30.75/ 9.61)	...........................NLIIILYS..ESNEKKIIMNTTNSSSTTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.13|      25|     302|     812|     843|       4
---------------------------------------------------------------------------
  812-  839 (38.44/19.54)	DIIPDVIRkcvLGDYILKLNNDLYITAT
 1104- 1128 (42.68/15.17)	NIIPQFQS...FIDQVIKLNSSSNINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.16|      26|     302|    1037|    1062|       5
---------------------------------------------------------------------------
  531-  557 (38.21/21.63)	KEKQQPELIVCYRINHyVKITVDERTG
 1037- 1062 (42.95/25.28)	EEMNSPLTIVKESLNR.IKLTYNDQYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.06|      49|     302|     884|     952|       6
---------------------------------------------------------------------------
  895-  950 (69.73/58.73)	SVKtkvLTFTYSkiNNCIYKILN.IW...KGLLILRIIASQAYS..NKDilKNNEM..TIDKIN
 1246- 1288 (41.07/13.14)	......LLLTYT..NDHIELILTyVYvddKWTMSLKILSEKA..........DCEV..LINKI.
 1290- 1335 (57.27/20.95)	KLK............NPIMGFKD.IT...QLMLLPPDIAKEVLSmiNKE..KEKQMngTTSEIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     211.27|      83|     869|     273|     366|       8
---------------------------------------------------------------------------
  228-  328 (125.10/74.65)	LDLKIFvkpddNLNHD.LIMPLQEYQLE.NIKINAQN...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sirtditnpnSNLPSSNSLNPT........QNSTSNQITNTSTNNNNNNNNTSEGDKPTK......PKKIwpLIEIYrYL
  335-  366 (18.87/ 8.02)	MHLEIF.....SLQVDyLIKTRWANQLRyNISPDKKT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1132- 1198 (67.30/24.31)	.....................................lqifywiennsgskydikskekkkanvlelsitsaedvivfytnkehdeyetnnsiiaksliyeyeqyiqsnlsikcyqlledgtkkelvdpstsskikfninsqklniekilervteihafsilyelrniligksnskiaihkcnckdiieknfynsktsdnekekqqpelivcyrinhyvkitvdertgriviteynesgtdninsfiqekikiveeqinkdlsnavddlislrnltiineiellsiylglepskkllitqeelrrlmnsnelfqsqniiylrypnypnyyiiiyidseeinsnvkhkhdvsyfkvwlvstqkknssgfleftlfmnldisqlienednynndienddfhhfrkrrcieepsvwdktknltldleilskieavcrykiaysllttqlknlhipyyfvsiksnnvidydsplsifdliikirvkdiipdvirkcvlgdyilklnndlyitatgntlnkdnnvapfdkfsiknsikgisrgievvaklqvkpgelpinedfsigdinfsvktkvltftyskinnciykilniwkgllilriiasqaysnkdilknnemtidkinllktkilfyeknfvefalntsldnsnsnginiifgvkgdnktsifyeekqfliedffkdynvinfllklktkyvlfkninlikksreemnspltivkeslnrikltyndqytieigqctdnliiilysesnekkiimnttnsssttnkinhhsniipqfqsfidqviklnsssningtslgSTLMSSSTLNSSsssiakieDNPTTATPTTTTTNNNNNNNNNNLKNENEDyvclkiPNGV..IFDIY.YI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.83|      56|     385|     164|     222|      13
---------------------------------------------------------------------------
  164-  222 (79.88/63.07)	NEEIKDAIEKLEDvTRLRLLcEEIIPKPMkKNYVIENGSVR.FTVENEFE...VTLKLEGKQQ
  565-  624 (81.96/50.60)	NESGTDNINSFIQ.EKIKIV.EEQINKDL.SNAVDDLISLRnLTIINEIEllsIYLGLEPSKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.06|      16|     385|    1006|    1021|      14
---------------------------------------------------------------------------
 1006- 1021 (29.07/14.06)	FFKDYNVINFLLKLKT
 1394- 1409 (29.99/14.74)	FFCEWNANPELSKLKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13751 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSIRTDITNPNSNLPSSNSLNPTQNSTSNQITNTSTNNNNNNNNTSEGDKPT
2) SSIAKIEDNPTTATPTTTTTNNNNNNNNNNLKNEN
262
1145
313
1179










Molecular Recognition Features






MoRF SequenceStartStop




NANANA