<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13740

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSSVQRVPSRVTSDKGNTQVPEAQTQPTMADLGRGTIPRQPEHSLSGNFSGSDYGSGSEAGSDTDLPQVTVDMIPLSVIVTRMVTYAYTELVTLIETLPSRTEENRREEIQKYTQHIREQLTKLLVLVKWSRNAPQIQKCQNAIAYLQSQNEYFTRAVDGLYATYLALPQARLRNYDVPTAVDVLTTGTYQKLPSVVKEAFVPPPMLTRAQVAQTLEAINGIIRARILRGGPVPTAMRRYSIDGGRVTFTVAGEFEATLTLLQYSNVPWHVVGIKLLVGSDPALTGEMAIRLDKRQTNDMAQHCQTQLLQESEVPQLARLYDFLHMQSLSILLDTVAKQAAVLRRVRWENLLQIEMGADKSVVLRYWTSSRAAAGHNSSGGSRGNAIVIKPCPLPVPRPIHASAIEGPDALEASPDDASDKHEFLRIEQDRRNLIPKLGLSITWTAHSGLGQTHTWSRTVAQASELSEDLANGGGVVLDSEGINAERLLRQVTWRHSVKILESLYSSVVESGLFDEGAVELLYGMASGEVKRSVSASEITQAAVVPKLRAWYRQDEGAVDITVDAFTGRLVVRASEVVSVSASLSEAMIGQLADQANRTPWRLAELLVDMRSSLALADLDSLAFRSLGLRPMGMATCGLLPGFVLTGVRRRVEASVTPAVASAQSYLMGSPAVGSNGPVPAAANFPLRISQQEADALMRGIGTEQPLNRVRFYKIEGCDGEWYLMGAMTDRLHFRLVLLNPHPKDQLMYEVGQVIALQVDRLFSSVARRLLAEKKLDPSMVRANSGSGGQSKRLREDGAEWDVTERVDAMLSGRTSITLDYLNALASMCRARLALRLLQTQLTEWKIPYSFRIPSFSTSPHGHRAAVSKELSVVGLDKQGLYELDEQVPILYLPIAALMRASPINWHVASSGVLADEARRMVSVRIASDELDPAMRSDSARLVEYRTSDGKASSAAQTLVGRHVIPCQVIASVPVALDGLPAAVSAAHADAVYFGAHAGPDGGYHGRGSGNTKGGYSKMMLVYKNVGRALQSLIRDWSEHHLMTHVARQLCVWEQRSLRRMLAATTAFYPFCAGPYTGALTKMLGANEHAATELVLQCLDSRLLSISCRVPEPFTGDQQGELSYHLTMAEVEPESNRILRIGSTWPWAHGAGSSRRRMGFEVSADLSRWLRTLQARMNLTGNPLSILSLVIQMTPLSDILSTTGPMVNIRSLSPSLALDSMIPVGFVRMLGETEPEDKSKLVVDRLMTMKEHLRSSLAEISDLNVMPMYTAADNIRLVFNTRFVVDVRLVAYDTFHISDVVASARVFAGSLVAAGSSASAPAPLVTAAMEPIPRFAQWLEALSTKMTLDWARLEEAVTVLFKEVASDDVMGDRAADKAQRIRNLQRNLHRLRPGATKVEAFMYKFRELHMRQNSARAPPFVPLPPTALLCTNAQLLVTLRSLMMWMKMSVNVVDSIEAVVSKYVGTGHLSVDEVLVDRQEVLVAYTGCRGTVRCEYKLSLDAVPADDEQSEPQVPAEAADSAAAEEPAQKLAKLVGLFSVPKNLLRAAWDVRILPIVRPPKGVSERVAAYLSGIVDRLGAEKTASTLVKLLAMPAHLLEDTVHIAMEMTGKVSVASLETTHNFSIVLDTDASSVCFALTFALPDRNLTVVLSYMLLTGTAEVVHVIVDKTAPNVVNQALEERWRAYVKKVIKKLDDLTAFTLDMGKDGKSRWLDIVKELHAEAYADHQSSA
Length1731
PositionTail
OrganismLinderina pennispora
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Zoopagomycota> Kickxellomycotina> Kickxellomycetes> Kickxellales> Kickxellaceae> Linderina.
Aromaticity0.06
Grand average of hydropathy-0.063
Instability index41.10
Isoelectric point6.98
Molecular weight189727.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13740
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     490.00|     146|     208|     696|     846|       1
---------------------------------------------------------------------------
  608-  695 (84.83/49.42)	...................................VDMRSSLALAD.LD..SL.AFRSLGLRPMG....MATCG.....LLPGFVLTGVRRRV........EASVTPAVASAQSY.LMG.SPAVGSNGpvpAAANFPLRIsqqeaD............................................
  696-  846 (242.28/175.18)	ALMRGigteQPLN.............RvRFYKIEGCDGEWYLMGAM.TD..RL.HFRLVLLNPHPKDQLMYEVG.QVIALQVDRLFSSVARRL......LAEKKLDPSMVRANSG.SGGQSKRLREDG...AEWDVTERV.....DAMLSGRTSITLDYLN...ALASMCRARLALRLL...QTQLTEWK
  897- 1054 (162.88/105.94)	ALMRA....SPINwhvassgvladeaR.RMVSVRIASDE..LDPAMrSDsaRLvEYRTSDGKASSAAQTL..VGrHVIPCQV...IASVPVALdglpaaVSAAHADAVYFGAHAGpDGGYHGR....G...S.............GNTKGGYSKMMLVYKNvgrALQSLIRDWSEHHLMthvARQLCVWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.97|     110|     329|     101|     218|       2
---------------------------------------------------------------------------
  101-  218 (168.07/120.53)	RTEENRREEIQKYTQHI.REQLTKLLVLVKWSRNAPQIQKCQNAIA.....YLQSQNEYFTR.........AVDGLYATYLALPQARLrnYDvPTAVDVLttgtYQKLPSVVKEAfVPPPMLTRAQVAQTLEA
  426-  550 (161.90/95.01)	RIEQDRRNLIPKLGLSItWTAHSGLGQTHTWSRTVAQASELSEDLAngggvVLDSEGINAERllrqvtwrhSVKILESLYSSVVESGL..FD.EGAVELL....YGMASGEVKRS.VSASEITQAAVVPKLRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.54|      45|      50|     221|     268|       3
---------------------------------------------------------------------------
  221-  268 (74.20/53.21)	GIiraRILR.GG.PVPTAMRRYSIDGGRVTFTVAGEFEATLTLLQYSNVP
  273-  315 (65.83/39.75)	GI...KLLV.GSdPALTGEMAIRLD.KRQTNDMAQHCQT..QLLQESEVP
 1137- 1174 (50.51/27.78)	.....RILRiGS.TWPWAHGAGS.SRRRMGFEVSADLSRWLRTLQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.13|      23|     623|     560|     589|       8
---------------------------------------------------------------------------
  560-  589 (28.92/28.35)	DITvdAFTGRLV.VRasevvSVSASLS.EAMI
 1198- 1222 (33.21/16.03)	DIL..STTGPMVnIR.....SLSPSLAlDSMI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13740 with Med14 domain of Kingdom Fungi
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