Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MSSNLTEQELTTVCFRDPQWLALNPLLIENVIEYFSYSQFYDKTCNNETIKMQSRFNQFDLAEMNKGLHDMTGIEYEVTLSMPPQLFVIAKQNRKSPTSASPIQYYYVINGTIYQAPNAYMLFANRIITSLHLINISFKEAFKSVRFDPDKGYWWSTDEKTDKEMINEIEEIENTNISYINQQESRIYQMRIDDRIAESVSKPIEIEEKVEEEKIKKTKPTALEDKLIVKEKKHSTSSVSSYGHSSKRRKKLNSTSSENMNSLSSKSGSYSSLNSSSISKSIKHETNGNISHHK |
Length | 294 |
Position | Head |
Organism | Piromyces finnis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Piromyces. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.711 |
Instability index | 54.11 |
Isoelectric point | 6.68 |
Molecular weight | 33969.84 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13724 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.39| 16| 16| 232| 247| 1 --------------------------------------------------------------------------- 232- 247 (29.53/18.73) KK.HSTSSVSSYGHSSK 250- 266 (23.86/13.67) KKlNSTSSENMNSLSSK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 79.48| 25| 27| 50| 76| 2 --------------------------------------------------------------------------- 50- 76 (39.89/29.33) IKMQSRFnqFDLAEMN.KGLHDMTGIEY 80- 105 (39.59/22.92) LSMPPQL..FVIAKQNrKSPTSASPIQY --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 33.16| 11| 16| 202| 212| 3 --------------------------------------------------------------------------- 202- 212 (18.99/11.80) KPIEIEEK..VEE 219- 231 (14.17/ 7.29) KPTALEDKliVKE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IQYYYV 2) KRRKKL | 103 247 | 108 252 |
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