<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13721

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDDKLINDLSINSIQNDFDLLPKNEANLIPLKLIYERVIQNYYSDLTTLSETIQTKSNEQKKIEIFKFVQSLNQSAIKLLVLIRWAKKSRDVLKCKNICDFLEVQNSYFRGAADALHMVHQEMNAARIPSFDIPTAVDVLTTGTYSRLPTIIKEPISLPPLKTEEIKDAIEKLEDVTRLRLLCDEIIPKPMKKNYVIKNGSVRFTVENEFEATLKLEGKQQDNWRLLDLKIFVKPDDDLNHELIMPLQEYQLNNLKINAQNAISTDVIPLAENATLINSTQNPTNNQASSSSSTEETKPKKKWPLIELYRYLHSFCLSMHLEIFSLQIDYLIKTRWANQLRLNISPDKKTLQIYYWMANDFKNKQSKANILELSISTAEDKIVFYTNKEHTEEETNSSLIAKSLIYEYEKFIQCKLNIKCYQLLENGTKKELIDPLTSSSIKFDINSQKLNIERILERVTEIHAFSILYELRNILLGKSNTKIAVHKCNPNDIIEKNFYNSETTDEQKDKLQPELIICYRINHYIKITVDERTGRIVVTEYNEQGTDNINSFIQEKIKIVEDEINKDMTNAVEHLMNLRKLIIINEIELLSIYIGLEPSKKLLINQEESKRLINNNELFQSQNIIYLRYPNYPNYYIIIYIDNEAINSTKKYKHDISYFKVWLVSTQKKDPLEFLGFTLIMNLDISQLLEDSNDSDNDIENDDFFHHRKRRCTEEPSVWDKTKNLTLDLEILSKIEAACRYKIAYSLLTTQLKNLHIPYYFVSTKSNNHAINFDSPLSVFDLIIKIRVKDIIPDVIRKCFLGDYILKLNNDLYITATGNTLNKENNSIPFEKFSIKNPVKGIARGIEVVAKYQVKPGELPINEDFSIGDISFSNKTKVLTFTYNKINNCIYKILNIWKGLLLLRIIASQAYTNKDILQSNGMSIDKINLLKTKILFHEKNFVEFALNSSLDSSNSSGINIIFGIKGEKTPIFYEEKQFLVEDFLKDYNVINFLLKLKTKYKLFKNINAIKKSREQIDLYSPLKIEKKSLEKIKMIYNNQYIIEIGQIADNLVGILYSDNSINDIRNLTTRNIPPIILPQFNRFIDFVTQLVITGGKSQQENSIIKSENDQGNMDENQKDSVCLKIPNGIIFDIRYIDEVMVELQKIMNSVSYMDWLYAAIPQIEQTKASPQKGSISYSKNSTDPLYLIYNGQSFELSINYDFKMNKWTMHLKVNNEDINSEILIKKILNLANPIIGFKSLTQLMLLPPDIAKEILDLINTESKPNDKGVTSEICLTIPEGLPSYLPRSGESAICSDFQNKRVGLFCHITYNDTSVNGVEGTKHSLIIPFFYNWESRFFCEWDINPEISKLKTFEECKTLLQSQSQNDSNRFSKLNLLLVNISMAKEQKGEKEPIKFAFTTLNSMTPEQYKVLEFRNN
Length1419
PositionTail
OrganismPiromyces finnis
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Piromyces.
Aromaticity0.09
Grand average of hydropathy-0.351
Instability index40.71
Isoelectric point6.43
Molecular weight164391.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1639.68|     416|     420|     554|     973|       1
---------------------------------------------------------------------------
  154-  540 (447.13/274.85)	.IKEPISLppLKTEEIKD...AIEKLEDVT...RL...........RLLCDEIIPKPMKKNYVIKNGSVRFTVEN...EFEA.TLKLEGKQQD.NWRLLDLKIFV...........KPDDD...................LNHELIMPLQEYQLNNLKINAQN...AIstdviplaENATLINST..QNPTNNQASSSSSTEEtkpkkkwplielyrylhsfcLSMHLEIFSlQIDYLIKTRWANQLrlnISPDKKTLQI.YYWM.ANDFKNK....QSKANILELSISTAEDKIV...............FYTNKEHTEEETNSSLIAKSLIYEYEKFiQCKLNIK..........CYQLleNGTKKELIDPLTSSSIKFDinsqklNIERIL.......ERVTEihafsILYELRNILLGKSNTKIA...VHKCNPN.DIIEKNFYNSETTDEQKDKL..QP.ELIICYRINH.........yIKITV.DE......RTGRIVV
  554-  973 (662.93/428.39)	FIQEKIKI..VEDEINKDMtNAVEHLMNLR...KLI.IINEI....ELLSIYIGLEPSKKLLINQEESKRLINNN...ELFQ.SQNIIYLRYP.NYPNYYIIIYIDNEAINST..KKYKHDISyFKVWLVSTQKKDPLEfLGFTLIMNLDISQLLEDSNDSDN...DI........ENDDFFHHR..KRRCTEEPSVWDKTKN....................LTLDLEILS.KIEAACRYKIAYSL...LTTQLKNLHIPYYFV.STKSNNHAINFDSPLSVFDLIIKIRVKDIIPDV.IRKCF.LGDYILKLNNDLYITATGNTLNKENNSIPFEKF.SIKNPVKGIARGIEVVAKYQV..KPGELPINEDFSIGDISFS......NKTKVLTF...TYNKINN.....CIYKILNIWKGLLLLRII...ASQAYTNKDILQSNGMSIDKINLLKTKIlFHE.KNFVEFALNSSLDSSNSSG.INIIF.GI......KGEKTPI
  974- 1396 (529.63/327.28)	FYEEKQFL..VEDFL.KDY.NVINFLLKLKtkyKLFkNINAIkksrEQIDLYSPLKIEKKSL...EKIKMIYNNQyiiEIGQiADNLVGILYSdNSIND..IRNLTTRNIPPIilPQFNRFID.FVTQLVITGGKSQQE....NSIIKSENDQGNMDENQKDSvclKI........PNGIIFDIRyiDEVMVELQKIMNSVSY....................MDWLYAAIP.QIEQTKASPQKGSI....SYS.KNSTDPLYLIyNGQSFELSINYDFKMNKWTMHLKVNNEDINSEIlIKKILnLANPIIGFKSLTQLMLLPPDIAKEILDL.INTE.SKPND.KGVTSEICLTIPEGL...PSYLPRSGESAICS.DFQ......NK.RVGLFchiTYN..DT.....SVNGV.EGTKHSLIIPFFynwESRFFCEWDI...N.PEISK...LKT...FEEcKTLLQ..SQSQNDSNRFSK.LNLLLvNIsmakeqKGEKEPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13721 with Med14 domain of Kingdom Fungi
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