<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13718

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNSHILEDNSVTNIFSLKGVSKIKWRRYYYIYNSGRNVSSSFQSLESGLLKDPIISTYLKLIEKGILCVWINGQYNSEDEYGGKPTKIFSKSENLINISKTTEEIDSNSNTNTKEQCKELWIFQYDSEQELNQTEIENLIELEEGEFNFETLNNLYIQDPNYEFIEYHLFIKAIYNLLERNFYKHGIFRLGDHFIFTEFPQENSIFMLSKENDTRSLLSCQITFIYTSSNLLLQPVIRQHQFLRPIELYDINYADKIIKNINNSYINNLDNNSNNINKLNSEGYNNSNQNIKHSNILILLSPHGIPAYLYSSDIQNSNDIDYILDEWSKCFGIPKEKLYFNKKHEIPLVVTVYIPDMNCYINYPTKCIYIVDSKNIYNISRKLCFNPRIYHQFIEYTWRDQSIHDDTLIFSKLNNSIKHETNDIINHVSNINSELNNNLVDVKKELDESNPNKTLNNLAKDNKDIDFFNYTTPEKKLLIELLKEEKLINEMEAEITSNNNNNGNNNNNNRNINNPNTPNTSKMNSPFSNPQQLINKNNKIQQNMISIPSKSAKIKEEKKRKMPVDNKKNKKEKKEIDEIKVEKPVTVENNPQVEDNYVMSGIFNDSNFDDFGDWGTEIEITDKDFDFFDDKPSQNKTISDMDFGMDGMLTSTVLDNSNKPSLLNNLTQNTLVDINIKEKDSFNFKNSLPSTPINQDIGTPSSINANMSINSIHNSPAPMSISPINNIIPSQNNLLSNNTITNKLMTTVPNTISSPLINSQFQDSTFSLSNNITKDNSTAMIPSNDNLLLNGINDDSKNDVSNENNHENINSDNNNNNNNTNNSNNNNNNTNSNAVNTISNSNTNSSVPTMNSNSINNNNDLTIPSEWELKSSNREYIDNLVEKYHTGKWSYEPKLKSYLISFKRKKISKKELYRFVMSKRIKYKEDIIIKDKNNDNLSKEIKEENSNQEENQEYNNKKIKIESDAEEKNIAEIKENEINDNSNNNDNESQYNTYNTENKIFIDFGSAWKILNIHKYNPINDIIEKNLACKSINQIKGEDQHDIKKLKSEEEEEKVNVLDKMAQKIFIDQYTGSLSSWNKSLENSLSTVILSEENQLYDEHIIPSLASKVLSQIQVIFEDLFGSDIDQKIGMKNIYIEGPLTIKQLYDSEHSQHAKYGKYQVKKKTKKNIDYVLEKLVTPDIIVEDNNEWIKLSSTSLRFWDKIGILPYSGKKNINWFVLCPTTKEFNGEPNNNSDLVNIVKEWFKNLSYIYESSNFGSHKPGKLNSIMNGIIPCLLNDNNNTTTIENHLYSYERAISYFASMMAENIHGIIEEGEATIMSDVDECLNNDHNYIVLYLLNPFSSSDKSFINEKEEKLINYKFCQIFVNSLLYRLALSSRLSIEKLKSKIILQIIPLDLIANNHSFDSYVVIGLKDLVFTLYSKCRKLLQKNININNTEFSIYNDLYQPPYILSQTAIPIPHFSFKPFTRKHQLKNRVNIMEPDRILHIAYVNIDRRTIACMTDQIGELFDIIVVDDTNEKLTSITPLDYEKYTKQQIRFIKIWEKAMKLILFGCNFYWRIAIIKIGHVLQQEINDWEFISSFYLEKLKHTYQQPSLKIINNLNEQLYSVSILGICKNSSFQIFKEKIKPTVNNLNPLTRRDSEKSYSSSFSLQNNTKTPTTPSSKNEMNELNDIVINLSNSYYTYIHSVQRSPSFPSNPEIIWPLLLENYNIKDNLALPLSIGWMIYTPTMESKQVGINTKNFEILLLSHQYSNILKPNKTCFPTWNPTIPTTPISIPNSPSSSTSVSISKNINGNPSTLLKSNSINLKDMNSPLSMVSSSSSLSLNTSTSVPYNVILSDIIKQYFSLSFLEMHWSNLINTANGCASDDLRLPIHVSSVNRLSKILNNFHFK
Length1891
PositionKinase
OrganismPiromyces finnis
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Piromyces.
Aromaticity0.09
Grand average of hydropathy-0.603
Instability index41.19
Isoelectric point5.75
Molecular weight218204.01
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	
ECO:0000256	a target='_blank' href='https://www.uniprot.org/unirule/RU364134' style='color:#FF0000;'>RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
preribosome, small subunit precursor	GO:0030688	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
rRNA processing	GO:0006364	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13718
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     981.09|     157|     158|     462|     618|       1
---------------------------------------------------------------------------
   76-  197 (69.64/15.14)	........................................................................................N..SEDE....YG...GKPTK..IF.....SKSENLIN.......ISKTTE..EIDS....NS.NT................NT.........KEQCKELWIfqyDS....EQ......EL.NQTEIENLIELEegefnfetlN.NLYIQDpnyefieyhlfikaiynllerNFYKHGIFR......LGDHFIFT
  212-  370 (146.11/39.30)	NDtrsllscQITFI.YTS..S..NLLLQPVIRQH...QFLRPI.ElYD.I..NYADKIIK....NINNSY....IN............NldNNSN....NI...NKLNS.eGY.....NNSNQNIK..HSNiLILLSPH..GIPA..ylYS.SD................IQnsndidyilDEWSKCFGI...PK....EKLYFNKKH...EIPLVVTVYIP.........DmNCYI.......................NYPTKCIY..............I
  462-  618 (265.27/76.94)	NK.......DIDFFNYTT..P.EKKLLIELLKEE...KLINEM.E.AE.ITSNNNNNGNN....NNNNRN....IN............N..PNTP....NT...SKMNS..PF.....SNPQQLIN..KNN.KIQQNMI..SIPS....KS.AK................IK.........EEKKRKMPV...DN....KKNKKEKKEI.DEIKVEKPVTVE.........N.NPQVED.....................NYVMSGIFNDSNFDDFGDWGTEI
  622-  766 (117.23/30.17)	DK.......DFDFFD.DK..P.SQNKTISD........MDFGM.D.GM.LTSTVLDNSNKpsllNNLTQNtlvdINikekdsfnfknsL..PSTP....IN...QDIGT..PS.....S.....IN..ANM.SIN......SIHN....SP.AP................MS.........IS.....PI...NNiipsQNNLLSNNTItNKLMTTVPNTI..........S.SPLINS.....................Q......FQDSTF..........
  770-  939 (133.17/35.21)	.N.......NITKDNSTAmiPsNDNLLLNGINDDsknDVSNEN.N.HEnINSDNNNN.NN....NTNNSN....NN............N..NNTNsnavNTisnSNTNSsvPT.....MNSNSINN..NND.......L..TIPSewelKS.SNreyidnlvekyhtgkwSY.........EPKLKSYLI...SF....KRKKISKKEL.YRFVMSKRIKYK...............ED.....................I.....IIKDKNNDNLSK.....
  950- 1081 (148.68/40.11)	.............ENQEY..N.NKKIKIESDAEE...KNIAEIkE.NE.I.ND...NSNN....NDNESQ....YN............T..YNTE....N.....KIFI..DF.....GSAWKILNihKYN.PIN.DIIekNLAC....KSiNQ................IK.........GEDQH.......DI....KKLKSEEEE.......EK.................VNVLD.....................KMAQK.IFIDQYTGSLSSWNKSL
 1082- 1190 (100.99/25.04)	.......................................ENSL.S.TV.ILSEENQ........LYDEHI....IP............S..LASK....VL...SQIQV..IFedlfgSDIDQKIG..MKN.IYIEGPL..TIKQ..lyDS.EH................SQ.........HAKYGKYQV...........KKKTKKNI.DYV.LEKLVT...........P.DIIVED.....................NN...............EW...I
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.10|      29|      31|    1781|    1810|       2
---------------------------------------------------------------------------
 1781- 1810 (43.83/23.72)	SSSTSVSISKNINGNPSTLLKSNSInLKDM
 1812- 1840 (48.27/22.55)	SPLSMVSSSSSLSLNTSTSVPYNVI.LSDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.32|      18|      34|    1645|    1662|       3
---------------------------------------------------------------------------
 1579- 1594 (22.94/10.21)	..SSFYLEKLKHTYQQPS
 1645- 1662 (33.58/18.61)	YSSSFSLQNNTKTPTTPS
 1682- 1696 (25.81/12.48)	YTYIHSVQ...RSPSFPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.65|      19|      60|    1389|    1407|       6
---------------------------------------------------------------------------
 1389- 1407 (32.10/16.47)	ILQ..IIPLDLIANNHSF........DSY
 1423- 1449 (24.81/10.82)	CRK..LLQKNININNTEFsiyndlyqPPY
 1450- 1466 (21.73/ 8.43)	ILSqtAIPIP....HFSF........KPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.79|      32|     294|    1307|    1347|      11
---------------------------------------------------------------------------
 1307- 1347 (49.44/46.56)	IHGIIEEGEATIMSD.VDECLNNdhnyivlylLNPFS..SSDKS
 1610- 1644 (47.35/26.39)	ILGICKNSSFQIFKEkIKPTVNN.........LNPLTrrDSEKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13718 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSTFSLSNNITKDNSTAMIPSNDNLLLNGINDDSKNDVSNENNHENINSDNNNNNNNTNNSNNNNNNTNSNAVNTISNSNTNSSVPTMNSNSINNNNDLTIPSEWE
2) NEMEAEITSNNNNNGNNNNNNRNINNPNTPNTSKMNSPFSNPQQLINKNNKIQQNMISIPSKSAKIKEEKKRKMPVDNKKNKKEKKEIDEIKVEKPVTVENNPQVEDNYVM
763
489
868
599










Molecular Recognition Features






MoRF SequenceStartStop




1) IEITDKDFDF
2) KIKWRRYYYIYN
618
22
627
33