<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13712

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASSDLLNNLPASASIPVYGHWALRFHETIQCRRYTIASEDAKAGSSSLDPDLRLEHAWRQINSTTLTDVADILDSGCAIVAPVKNEQSPEKSSDSTPCLWVFSSGRKELNIPGLQEEPEASIDPLDLISCDVHGSNYDCLKRPGVREGGTVESRDKCRNLRWTPKPAVARAWSLLTDALVESLAWRKGRRVIMQPIHQAYEGHTELQGLLYPLSRDKCALRIQAKEPPRISPKDLNVLDMPNQLVFVRPLYLPAITLGPFSPNDTQSTILSESFSAALGSTWNTDRTGKQLVTELDRTVYNAWSVVWVPRLKSNDKSVDSWTLSQGILTVWPTHLLLDACPTRPTSIPVSQPPGSIFASTTPDDLMASATEIYQLMSREASFPTAQFHPSDATTVVPPDQSAAVISPESPIFGSESEQGDKSDIDDLFSAHSGEDEPVVETKRPVKAEVDFELLSEIADEDEVQEEEKQVQLERDVIMDFAQEQDSEDEGEGEAEGEITQITEDDFAFFDSPRSPQDEVFPTAQTEEEPYRAPEEEAAEPVETVEPKPELDEHPVEAKETDGDTSIVRPVKQVQFAPSPPLLDHSHTHSSPEFDLIPTDFVPLHLGPVRASAFPYSLPSPATTPEALRVELVDRLRKPNSKYKDDYAAAWDVESDVSDMEPDDGSPPGPLTPESMMDDGSAAGNQSLISTESASEADQELRWRSKKCISADWLWLREQAVDVLAVPWEIGWAGGSKSDAAVEPEDHVVDSSILEELDCSRLANHILADRHLRMYIEGSDAFRVNVAVAEAHEDDTLAWMRQGSALCEFIDHHDNEMHNPSGNPKSLAPLSVHVGFAGSVMSLGAAGLRYWPQLGLEPVGGRKDIAFSVLHEKASGAEGATLRFLQALEGVYESLGLGKLTKQGSIWEQVAACDPSDLVITLNTRLCQDLDGAAIFCILFSTDLQTIIRAGFSSKIIDPTQDGHIYHIFPGRFPSQEDLVTIAFDIYDRIPRPVRPISIRGLPMSSSVASIQSPHFTLVNEDQRKPELTLAWPLKSYDVMNRWTMIHCAYDYDEDLDMAVAMVLDDQGQSWRLGTFLGLKDSGTRIAKLWDYINDVAEQMAVEYRLTIFAPPTLSVVELNCWKSAIVKSKIPTSIVHASGTASSRIKQTSLKPIGAIPPALFADASTRLIDESLTAYYASHYTRAPVHLPARPDSSSHHLLFPHSVFLLSIAMPNLSYESTTLSVLYHESPPGKSDEDISLLLAGAIYRLIALGRLRFGFDSSRPAHVEGVNKVLSCFRKIAAV
Length1284
PositionKinase
OrganismKockovaella imperatae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cuniculitremaceae> Kockovaella.
Aromaticity0.07
Grand average of hydropathy-0.304
Instability index54.28
Isoelectric point4.72
Molecular weight141586.19
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13712
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     895.18|     280|     359|     579|     900|       1
---------------------------------------------------------------------------
  116-  189 (54.11/17.07)	..........QEEPEASIDPLDLISC...DVHGSN...YDcLKRPGVR.EGGTVESRDKCR...................................................................NL.............RWTPKPAVARAWSLLTDALVESLA..WRKG.............................................................................................................................................................................................
  579-  900 (438.22/324.44)	SPPLLDhsHTHSSPEFDLIPTDFVPLHLGPVRASAFP.YS.LPSPATTPEALRVELVDRLRKPNSkykddyaaAWDVESDVSDMEPDDGSPP.....GPLTPESMMDdgsaagNQSLIstESASEADQEL.............RWRSKKCISADWLWLREQAVDVLAVPWEIGWAGGSKSDAAVEPEDHVVDSSILE..ELDC.......SRLANHILadrhlrmYIEGSDAFRVN.......VAVAEAHEDDTLAWMRQGSALCEFIDHHDN.EMHNPSgNPKSLaplSVHVGFAGSV..MSLGAAGLRYwpqlglepvggrKDIAFSVL.HEKASGAEGATLRFLQAlEGVYESLGLGKL
  953- 1256 (402.85/225.69)	SSKIID..PTQDGHIYHIFPGRF.PSQEDLVTI.AFDiYDrIPRP.VRPISIR.....GLPMSSS........VASIQSPHFTLVNEDQRKPeltlaWPLKSYDVMN......RWTMI..HCAYDYDEDLdmavamvlddqgqSWR.....LGTFLGLKDSGTRI.AKLWD..YINDVAEQMAVEYRLTIFAPPTLSvvELNCwksaivkSKIPTSIV.......HASGTASSRIKqtslkpiGAIPPALFADASTRLIDESLTAYYASHYTRaPVHLPA.RPDSS...SHHLLFPHSVflLSIAMPNLSY............ESTTLSVLyHESPPGKSDEDISLLLA.GAIYRLIALGRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.53|      21|     135|     383|     404|       2
---------------------------------------------------------------------------
  349-  369 (37.78/15.66)	PVSQPPGSIFASTTPDDLMAS
  384-  404 (37.75/17.50)	PTAQFHPSDATTVVPPDQSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     150.91|      24|      24|     424|     447|       3
---------------------------------------------------------------------------
  424-  447 (39.94/19.63)	DID.DLFSAHSGEDEPVVETKRPVK
  449-  472 (26.32/10.44)	EVDfELLSEIADEDE.VQEEEKQVQ
  477-  500 (31.52/13.95)	VIM.DFAQEQDSEDEGEGEAEGEIT
  529-  548 (22.96/ 8.17)	..E.PYRAPEEEAAEP.VETVEP.K
  550-  572 (30.17/13.04)	ELD.E.HPVEAKETDGDTSIVRPVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13712 with Med13 domain of Kingdom Fungi
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