<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13710

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMANEDMELPDLVRSASNRGLSALKFVPLVTSWLAKKALEDQQSQDALTDALLSCLVSPHPPANILGYLTQCLLKSTITARTLAIHLLIYIYDGRSLSESTIISLSGLVMGSLTGLEPTSTIPSSLNRPIIPDIGSSDASQSIPTLSLLLPLLRQCTLPAAPAIVISFVHLLLSILEKHPAPPLDVGLEAGSLLQLLPEQLGLRLRDCLSGLMADLTDQNQLLNTTQQASGLPISAIPPLETRGDIPVPALPSGPLQLPLAKALQFTIIHALSASRWTPSPHYAARPPRLPENYSNIIRLGPQLCSDPATFLLHLLRTAVNIHNGEYVGSTFRGGQRWIFMTEHLPALIRWWKDQNIPDWACPEDIVTPLSTVFELETSPIEQKNGYVSGVMKQYISAADMDEEAGSFVHPEGWMLCTEQITILQRYSEFGLLNSQQLASLSSNISIPSHTPGESLMHRVASASKSHIRPISHIVIYAPGAARSFATEIMECISACPSVPPPEGLFVNLASEPDLLTAICGYVNSATILEAIQQHLLDVADDRGARAEDPQGALTRFGEAVILAEALVAIAELDPPELLRDARRSLNLPSMDEMQKSCVNGWVKALFGPDGIDDQVLLVTSPADFYRLAPSLIQQAITATAAGMLDLPTLHSGLSYFSQSLLSWSLGGITDWLCTEIVRNGHLSALHLNVLQNLVCSGALPVALLRVTGPAIASLLLPTSGLAPVFQSSAFDARGVQSKLNELNIAPQLSSVNALEDLRSEIQIVRNLNLAPESWASSLIKAMERALRVYPTASVSHLILEQLLQPTSALSGELDPFTAFSCLLLDLRFKATSPITGSQSFIDASIPALFDVDSAIVNDQIPISNLLLPVTSLCRATKHILLFASALNASQSDTLAHHLIDELLHLRARISTDGQEKNAKVKRRDPGMNSQQKAVLEALAGALGADEELRDRWSRFGELVGSPR
Length963
PositionTail
OrganismKockovaella imperatae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cuniculitremaceae> Kockovaella.
Aromaticity0.05
Grand average of hydropathy0.143
Instability index57.50
Isoelectric point5.23
Molecular weight104007.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13710
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.40|      20|      20|     142|     161|       1
---------------------------------------------------------------------------
  135-  154 (30.73/12.76)	SSDASQS...IPTLSLLLPLLRQ
  155-  177 (26.67/10.14)	CTLPAAPaivISFVHLLLSILEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.15|      15|      22|     765|     786|       2
---------------------------------------------------------------------------
  741-  755 (25.90/ 8.03)	ELNIAPQ..LSS.VNALE
  766-  783 (17.25/18.30)	NLNLAPEswASSlIKAME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.92|      21|      21|      47|      67|       4
---------------------------------------------------------------------------
   47-   67 (35.68/21.30)	LTDALLSCLVSPHPPA.NILGY
   68-   89 (27.00/14.09)	LTQCLLKSTITARTLAiHLLIY
  104-  124 (30.23/16.78)	LSGLVMGSLTGLEPTS.TIPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.63|      15|      21|     435|     449|       5
---------------------------------------------------------------------------
  435-  449 (26.32/15.16)	QQLASLS.SNISIPSH
  457-  472 (23.31/12.56)	HRVASASkSHIRPISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.88|      22|      51|     248|     269|       6
---------------------------------------------------------------------------
  248-  269 (38.21/23.47)	PALPSGPLQLPLAKALQFTI.IH
  280-  296 (26.09/13.15)	PHYAARPPRLP....ENYSN.I.
  301-  322 (31.59/17.83)	PQLCSDPATF.LLHLLRTAVnIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.81|      22|      22|     790|     811|       7
---------------------------------------------------------------------------
  790-  811 (36.66/20.99)	PTASVSHLILEQLLQPTSALSG
  815-  836 (39.15/22.92)	PFTAFSCLLLDLRFKATSPITG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.86|      28|      53|     552|     581|       8
---------------------------------------------------------------------------
  552-  581 (41.44/27.24)	ALtrFGEAVILAEALVAIAELD....PPELLRDA
  604-  635 (41.42/21.48)	AL..FGPDGIDDQVLLVTSPADfyrlAPSLIQQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      22|     162|     699|     727|       9
---------------------------------------------------------------------------
  699-  721 (33.45/27.94)	LPvALLRVTGP......AIASLLLPTSGL
  845-  872 (32.10/10.43)	IP.ALFDVDSAivndqiPISNLLLPVTSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13710 with Med5 domain of Kingdom Fungi
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