<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13703

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSNPNVTMEPTYQNGSMVASTSKVNTVESNGHIDLSEPMMDGPKPTTVHPHNPQLGPEPWFTYPTPTPSQLEQDLPPYDEIEGVPLGLVLDRVVRKGYGDMKTLLGQTLPSATTKNRPRHVIEYAKSQRQAVLKYLAVLRWKMAVDIDIPGPSTASHPHPLAQHAYNANSHPTPSFPTPHSIGESSNTSPSAEVISGKGKGRATEDDGAVMPRGKVTDAKRITHFMEHQNRQHEQAIGHVQHVAKMIEALRERNPDLLTAIALLETGTYSRLPTALTESFAPLVPLTNRKILRTLRKLNRSLLYRLKCVDYVPPELIIRAVRDGKVYVAGGGNHGWRASLTMVANGDGGEDSRWWLTGIEWGWRYKGRGVHDPGGVGGFRKVTGEARQGILEVVNEEILRPREEHGDIGDNEDPAVATDHSADRKVDAPFVRLVNFIEHLNLTQQLEALYLEAMRLNQGRWRSSLQVEMKRDESVLIVRYWIRPRPTAPPNAAQPKRGQDSRYIFGGTLSIAVAETGKPSMLNDLFCGIQTGGVIPSERVLNLRLDVKWEIGEAGSAGTLKAGEVMDSSSLRIDSSNLSLEDALNTAARAHATHLLQAYTSSLDISRLTLLPLKPPNLITHPASQGLNDEPIDHYAIPLPSKQGDSALKITVSPFNGYIEIADETGNEGRTLRARMATISVNESKLRMTDDLVRLITAIITENLENQMRQLGWIPVRRLPIRYQDLPKNDLFPASSVFVPLPTSTLHHLVAKVTPAGIVFELLRLVRTPSDGGVMKFAIGDRSVLDMARLKARRPRGSVDRGVEAAGATVADPTGVNALLSAVGQDTPASPSESSFEIANRDLMDMYIFSNALVAQTIIEQQLKDRSIPYTLQYPPITGKGAPKSSSAVAGMIPALCVNTRDLLKDARVAEVAMPRVYIQIRDWWKGHQCQVVTVVQLRHRPSLASAATSPLPPTVSVPSTASNSDSITLDPSSSIVRFRENDISRCVPSFLEEWERLSKVLVVAGEVNRLNKSAPFKHLKMLAFDLCTATLSYAPGYSCSITYTPSDDSYEVSFSTTTGTDGEVLSESAKNPHEMLQDLFSHKLNELSKARNVKISLAKAFCELLCNTLPILLTINNLRSTSRDFPKLVVRSISAYRLVWDVDAKRYALDVSLARSNRCIVSDGSIDTLDTSCGPLTPIPGFEQHTMGIKTEFEGGIAAEGAGEGEGEGEGEEGGQEKRKESERLVLLDEGRAILCPVHLVSQVMTSLAAAIETSVGYRG
Length1261
PositionTail
OrganismKockovaella imperatae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Cuniculitremaceae> Kockovaella.
Aromaticity0.06
Grand average of hydropathy-0.298
Instability index41.19
Isoelectric point6.64
Molecular weight138169.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13703
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.15|      23|      54|    1006|    1032|       2
---------------------------------------------------------------------------
 1006- 1032 (28.77/40.61)	GEVnrLNKSAPFKHlKMLAfDLCTATL
 1063- 1085 (42.38/33.08)	GEV..LSESAKNPH.EMLQ.DLFSHKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.90|      32|      56|     755|     787|       3
---------------------------------------------------------------------------
  755-  787 (52.90/36.40)	PAGiVFELLRLV..RTPSDGGVMKFAIGDRSVLDM
  813-  846 (52.00/31.22)	PTG.VNALLSAVgqDTPASPSESSFEIANRDLMDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      14|      42|     245|     258|       4
---------------------------------------------------------------------------
  245-  258 (23.39/13.09)	KMIEALRERNPDLL
  290-  303 (20.28/10.37)	KILRTLRKLNRSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.56|      33|     105|      40|      78|       6
---------------------------------------------------------------------------
   40-   76 (64.17/42.66)	MDGPKPTTV.HPHNPQLGPEPWFTYPTPTPSQleqdLP
  147-  177 (54.84/27.16)	IDIPGPSTAsHPH.P.LAQHAYNANSHPTPS.....FP
  615-  642 (40.55/18.75)	...PPNLIT.HPASQGLNDEPIDHYAIPLPSK......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.60|      22|     147|     394|     450|       7
---------------------------------------------------------------------------
  215-  237 (36.97/ 8.73)	KVtDAK..RITHFMEHQN.RQHEQAI
  425-  449 (29.62/28.87)	KV.DAPfvRLVNFIEHLNlTQQLEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.39|      19|      26|     331|     349|      11
---------------------------------------------------------------------------
  331-  349 (37.89/22.70)	GGNHGWRASLTMVAN..GDGG
  358-  378 (35.50/20.80)	GIEWGWRYKGRGVHDpgGVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.18|      14|      27|     533|     546|      12
---------------------------------------------------------------------------
  533-  546 (23.58/16.58)	GVIPSERVLN...LRLD
  558-  574 (18.60/11.30)	GTLKAGEVMDsssLRID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13703 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIPGPSTASHPHPLAQHAYNANSHPTPSFPTPHSIGESSNTSPSAEVISGKGKGRATEDDGAVMPRGKVTDAKRITHFMEHQNRQHEQAIGHVQHVAK
2) MSNPNVTMEPTYQNGSMVASTSKVNTVESNGHIDLSEPMMDGPKPTTVHPHNPQLGPEPWFTYPTPTPSQLEQDLPPY
148
1
245
78










Molecular Recognition Features






MoRF SequenceStartStop




1) LIVRYWIR
476
483