<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13677

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGMAAPAGVPTGPPEPPPQKHEPVPLAQLVQRTTSEAYTGIQDLCKSLPGRGEKERKLALLKYLVRTRQRLLRLHVLAEWAKTQAPLMSRGQQLSGTLEWHDTSLRDAADQLFFLHAQLRQARAPIYDVTTAVEVLTTGSYSRLPIVIQDLRPPPTLVPSEQASALSKADRAIHARLLECELPPQLTDIRVSDGAVRMRVKDEFEVRLTLGHEGDLSKWRVLWLALGSEAEGRVTKDGSEDQGFGEKTRGVRGGGSRGLTEGQRRALAAEVERRMGLAAEPLHEMYRVLHELAANLLLDSVFRQAQVLKQGTWRDVIRLHFEKGDAGSVHRSLKIEYWDRRSPGGVNTLQSGSASVEPFRPSPSSHLTPQLDQPLRGETPVSGGKNWALKGPPSLRIELDDEGHVACSHWPVVVDPESEESALFSVAQHGGSLEELLRKALACSAHSRLLELEEIVNKEPLVRCKRSFREGGVAFGSLDEGRAEEEENQEGAEKLWVQVYGSVGAGVEVNRRSGRFVLRQPVGLVPDSLLRQLEERLNSGGDAPGSLFLELRKAALLRLFRSMAVEMELEPYAHGVAALDTPEDGPSLPPDTLLCSFPGVLEGFSFFLAISFDDFCIPFFTLLASDERDDDSASDRSEPGVSGPISGLVKGPVSGALSGALSAAVSGGVSASLTDRIAGAVGAGSGMGLAAVSRAVRRSFAVRPQVTKWMELGVGEKVIDDGDSEALLLGWGSESERAAMVEEEEKLRKRVELERAEAETQVQTGLTSVSLGAGWKEQSTGSLLGAKSKERSEDPLGLLKEWPDSVDLDTDWTEAPEALGGSGAPPLSTTLGGSVPHEEKPPESAGASTEAASGANASGVNTASVSAPTVKASGGPRFERSLTMDMVEGLLDMLGDEEEETKTETANLTGVSDNLPGASADLAEGAEGLEVWEGTTGGEETEAVGNGDGGTESVAEGGLKRPRESSMDIDIEAAFRGFGGTDESNGLAGQEGRAEGNDNGSEEPSAKRQKVGPEPSQATGLEAGQALTGVQMNGETAPEASDEKMEEAGSLAEASLDAAGALEDSILDFDPATAPKAEPLEGDAEIDTEMHASPRHPTTVDHVPEALAHVSESPKVEDRCRLAVGRRFSSLLAAANQGRAPPEVYRAALYRALAHCSLCIKHDVITRQLTSAGVAYAEEVGLRRPSFDLRAKVPGLDGGDDVAPSWPPVKVLLGGPGVPGVTIRVEDGYLGALAGLERRSKAGSALRDGSGVEDASIDEEKQNKVDEVTEGGAREGDKETADAPPNRDWLSRGDIHFLESAPEDAHIQSDAKGFEIRVKRITPSFATDLVRDLKRVWLARAFVLHLAEALGVLSGVHAGSDELEVLAGKRGVSDSWGEVTITGVGLTDVEVRFENFRTILMSVTWPRTSGGAKVSLLPQALETLEHQLEEFVNEGEVALLLDAVSVTAVPQGLLAESLPCTKLMRRAMYSPTEVELKLWSPYRARFTFRNCFTLEMRCFAGAHVWLQPVPPADPSSSRGYAQIPGFQWCVNEELAAARTCLEGGTTPDKGGPPERGGAGDKGTAAGGQGSGETEVGESLGVSEPPPEKLARFRSFGRASGSGGLQSFPSFGRQGSSGRGDSETLISPGSVSSGALKLPPPGSTFPGGRPRLTDTGGYAGMWVPWYAIPQVCRGLWPNLAVHWAVITFVECVQTTRELLTRDNEWQVLKHDASRPLLQLRCGSLAVQLSASSSSIRFKLQSGTQQESPITKVDAADLDEYFHARVLRSPHHRDRIASFVTLLALPIKTLRDFVGLIRWEKVEIVVERDRESKGQGGSNVVGEICLEKKPLPPGGSEFMAPFARGDPPVRERDPSGENAEESLRHVEGNVYYNRRKGVVDFALGFVCPVSHNRALWRQETAPGDWGGGLVGPERRFLLTWLRCSVQDESIQLLDVQGPLEPTAKERLTMLITTALDLNTRGESEGSKMQRAATAIQATLVSQ
Length1980
PositionTail
OrganismKlebsormidium nitens (Green alga) (Ulothrix nitens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Klebsormidiophyceae> Klebsormidiales> Klebsormidiaceae> Klebsormidium.
Aromaticity0.05
Grand average of hydropathy-0.351
Instability index46.75
Isoelectric point5.07
Molecular weight212431.86
Publications
PubMed=24865297

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13677
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.31|      12|      15|     523|     536|       1
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  523-  536 (16.73/14.97)	GLVPDSLLrqLEER
  541-  552 (22.58/12.48)	GDAPGSLF..LELR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     821.47|     224|     257|     651|     880|       3
---------------------------------------------------------------------------
  195-  408 (231.85/86.85)	AVRMRVKDEFEvrL.......TLGHE.GDLSKWRVLWLAL......GSEAEGRVTKDGSE......DQGFGEKTRGVRGG...GSRGL.TEGQRRA...........LAAEVERRmglAAEPLHemyrVLHElaanllldsvfrqaqvlkqgtWRDVIRLHFEKGDA.................GSV.H...........R...SLKIEY..WDRRSPGGVN....TLQSGSASVEPfrPSPSSHLTPQLDQ........................plrgeTPVSGGKNWALKGPPS..LRIELDDE..G.....HV.ACS.............
  587-  698 (82.33/29.76)	............................................................................................................................................................SLPPDTLLCSFPGVLEG.....FSFFLAISFDDfcipfftllasD...ERDDDSASDRSEPGVSGP....ISGL.................................................vkGPVSGALSGALSAAVSGGVSASLTDRIAG.....AVGAGSGmGLAAVSRAVRR
  701-  960 (336.73/133.65)	AVRPQVTKWME..L.......GVGEKvIDDGDSEALLLGW......GSESERAAMVEEEEklRKRVELERAEAETQVQTG..LTSVSL.GAGWKEQS......TGSLLGAKSKER...SEDPLG....LLKE.....................WPDSVDLDTDWTEAPEALGGSGAPPLSTTLGGSVPH...........E...EKPPESAGASTEAASGAN....ASGVNTASVSA..PTVKASGGPRFERsltmdmveglldmlgdeeeetktetanltG.VSDNLPGASADLAEGAEGLEVWEGTTGgeeteAVGNGDG.GTESVAEGGLK
  961- 1146 (170.56/61.84)	..RPRESS.MD..IdieaafrGFGGT..DESNGLAGQEGRaegndnGSEEPSAK........RQKVGPEPSQA.TGLEAGqaLTGVQMnGETAPEASdekmeeAGSL.....AEA...SLDAAG....ALE........................DSI.LDFDPATAPKAEPLEGDAEIDTEMHASPRH...........PttvDHVPEALAHVSESPKVEDrcrlAVGRRFSSLLA..AANQGRAPPEVYR..................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     664.55|     226|     282|    1276|    1555|       4
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 1276- 1555 (347.38/276.84)	GDKETADA..................PPNRdwLSRgdIHFLESAPEDAHIQSdakgFeirvkritPSFATDLV..RDLKRVWLARAFV....LHLAEALGVLSGvhaGSDELEVLAGKRGVSDSWGEVTITGVGL.TDVEVRF.........ENFRTILM.SVTWPRTSGGAKVSLLPQALetlehqleefvneGEVALLLDAVSVT...AVPQGLLAESlPCTK.........LMRRAMYSPtevelklwsPYRARF.TFRNCFTLE...MRCFAGAHVW..LQPVPPAD.PSSSRGYAQIPGfqwcvneelaaaRTCLE......GGT...TP.DKGGPP..ER
 1559- 1850 (317.18/170.51)	GDKGTAAGgqgsgetevgeslgvsepPPEK..LAR..FRSFGRASGSGGLQS....F........PSFGRQGSsgRGDSETLISPGSVssgaLKLPPPGSTFPG...GRPRLTDTGGYAGMWVPWYAIPQVCRGLwPNLAVHWavitfvecvQTTRELLTrDNEWQVLKHDASRPLLQLRC.............GSLAVQLSASSSSirfKLQSGTQQES.PITKvdaadldeyFHARVLRSP.........HHRDRIaSFVTLLALPiktLRDFVGLIRWekVEIVVERDrESKGQGGSNVVG............EICLEkkplppGGSefmAPfARGDPPvrER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.73|      15|      15|      57|      71|       5
---------------------------------------------------------------------------
   57-   71 (23.06/14.12)	KLALLKYLVRTRQRL
   73-   87 (25.67/16.63)	RLHVLAEWAKTQAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.57|      37|     269|     145|     181|       7
---------------------------------------------------------------------------
  145-  181 (64.23/36.79)	PIVIQDLRPPPTLVPSEQASA.....LSKA.DRAIHARLLECE
  411-  453 (52.35/28.50)	PVVVDPESEESALFSVAQHGGsleelLRKAlACSAHSRLLELE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13677 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMVEEEEKLRKRVELERAEAETQVQTGLTSVSLGA
2) CLEGGTTPDKGGPPERGGAGDKGTAAGGQGSGETEVGESLGVSEPPPEKLARFRSF
3) EQSTGSLLGAKSKERSEDPLGLLKEWPDSVDLDTDWTEAPEALGGSGAPPLSTTLGGSVPHEEKPPESAGASTEAASGANASGVNTASVSAPTVKASGGPRFERSLTMDMVEGLLDMLGDEEEETKTETANLTGVSDNLPGASADLAEGAEGLEVWEGTTGGEETEAVGNGDGGTESVAEGGLKRPRESSMDIDIEAAFRGFGGTDESNGLAGQEGRAEGNDNGSEEPSAKRQKVGPEPSQATGLEAGQALTGVQMNGETAPEASDEKMEEAGSLAEASLD
4) GLQSFPSFGRQGSSGRGDSETLISPGSVSSGALKLPPPGSTFPGGRPR
5) LEDSILDFDPATAPKAEPLEGDAEIDTEMHASPRHPTTVDHVPEALAHVSE
6) RDGSGVEDASIDEEKQNKVDEVTEGGAREGDKETADAPPN
7) VNTLQSGSASVEPFRPSPSSHLTPQLDQPLRGETPVSGGKNW
739
1540
777
1603
1062
1247
346
773
1595
1057
1650
1112
1286
387










Molecular Recognition Features






MoRF SequenceStartStop




NANANA