<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13673

Description Mediator subunit 8
SequenceMAAPSQGTPQAQVQPPGLPVPDSDLAPVLAQLNLTAVKNRAMELYASIGRLRDVFQPQYAGALRWPDILNQFAVLNTQLLNLVADMKPILRMFVVYPKAGGVGPETAPILPLMLSTKLLPEMEAERASLQEQLETKMGLTTPQRGGQPAQIPPPVQAQISRLQQQIETIRSACDAANRTIQAGRRTLSQHAASAYQPPAKPDPALVEKERLLRNAVLSGEGLKVANNAHPPKALPPHLAKVLAPSGGGPSSPRGGRPPLPSLRPGGSGFAVPMSPPGGSGGKAQGFKLPSPRVPSPYAAGSPRSAAQKPF
Length310
PositionHead
OrganismKlebsormidium nitens (Green alga) (Ulothrix nitens)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Klebsormidiophyceae> Klebsormidiales> Klebsormidiaceae> Klebsormidium.
Aromaticity0.04
Grand average of hydropathy-0.283
Instability index67.95
Isoelectric point10.27
Molecular weight32619.34
Publications
PubMed=24865297

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13673
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.62|      40|      42|      60|     101|       1
---------------------------------------------------------------------------
   32-   58 (25.85/ 9.56)	.........LNLTAVKN.RAMELY....A...SIG..RLRDVFqPQ...
   60-  101 (65.72/40.62)	AGALrwPDILNQFAVLNTQLLNLV....ADMKPIL..RMFVVY.PKAGG
  107-  146 (47.05/22.93)	APIL..PLM......LSTKLLPEMeaerASLQEQLetKMGLTT.PQRGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.19|      35|      42|     230|     264|       2
---------------------------------------------------------------------------
  185-  214 (32.63/ 6.96)	..RTLSQHAASAYQP....PAKP...DPALVEkerlLRN
  230-  264 (65.12/20.06)	PPKALPPHLAKVLAPSGGGPSSPRGGRPPLPS....LRP
  275-  309 (60.44/18.17)	PPGGSGGKAQGFKLPSPRVPSPYAAGSPRSAA....QKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13673 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQEQLETKMGLTTPQRGGQPAQIPPPVQAQISRLQ
2) NRTIQAGRRTLSQHAASAYQPPAKPDPALVEKERLL
3) VLSGEGLKVANNAHPPKALPPHLAKVLAPSGGGPSSPRGGRPPLPSLRPGGSGFAVPMSPPGGSGGKAQGFKLPSPRVPSPYAAGSPRSAAQKPF
129
177
216
163
212
310










Molecular Recognition Features






MoRF SequenceStartStop




1) KAQGFKLPSPRVPSPYAAGSPRSAAQKP
282
309