<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13668
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSDESRIRELSELIRNKCLQTRQQQQQAEGQAPNTAIQVQGAEVLSRLREVIVRLQEEIKDPSPAGIQQRLQYTASKLGLNYSNQRSANGVSCYLNTESFYVEVCVSDNGTVTSANVVLGQETQKNTDILVKLLQDCKYIEFEKHIKSLVDMFSQATGQDTAVLLLKAVFAIESILSSIENPNYSNPIDSILLNHLGIVTPRKAGLPMKLTFFITPSEGISAGLNQESSSSIIEGELDVGISAKVQVERSSTQFYRLPIDPNIFNSSQGAFAQLTEQNSVSVPLTLILSLNEDIPICTGIAEKLQQTVYLTTQTLPSLIAPHVDQLIISEASKKVKDSNVAKEHITNSVHTIYLPGQVHEYVGLGVHNEVPNLQRGVLLPNRSVPFTHPVHVIKIIYLLRQQLVYNTLLVSCLTRKRRGTVPATKSLDDYSFHVSTQPPEAIIMATQLLTTKGGVIPLKFKFVIPQEKVAPTQPVLHLQAGSDDQSMEQSPSLNKILAKSLSIPVTIHAGFSRPGVLPPSVAAAFKDHQDALKAFNSELTSCGIASGDFSSHMTSLSEQQLTGVAAGFKRKRPPV |
Length | 575 |
Position | Middle |
Organism | Amphimedon queenslandica (Sponge) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Porifera> Demospongiae> Heteroscleromorpha>
Haplosclerida> Niphatidae> Amphimedon.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.118 |
Instability index | 52.12 |
Isoelectric point | 6.93 |
Molecular weight | 62946.23 |
Publications | PubMed=20686567
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13668
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 98.89| 32| 138| 59| 91| 1
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59- 91 (53.32/32.17) IKDPSPAGIQQRLQY..TASKlGLNYS.NQRSANGV
198- 232 (45.56/23.35) IVTPRKAGLPMKLTFfiTPSE.GISAGlNQESSSSI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.58| 32| 39| 257| 289| 2
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257- 289 (50.06/39.17) LPIDPNIFNSSQGAfAQLTEQN..SVSVPLT..LILS
294- 329 (45.52/29.89) IPICTGIAEKLQQT.VYLTTQTlpSLIAPHVdqLIIS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 128.44| 39| 41| 352| 392| 3
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352- 392 (61.48/49.27) IYLPGQVHEYVGLGVhNEVPNLQRGVLLPNRSVPfTHPVHV
396- 434 (66.96/43.16) IYLLRQQLVYNTLLV.SCLTRKRRGTVPATKSLD.DYSFHV
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