<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13665

Description Uncharacterized protein
SequenceMYVEECRPLKRSKLGIPDVYPQEVRQREDELTIQTVNSGLRMAPAHSYENGSSRQDIQHLRSADFISRLNQIVDTKKRTAWGQDSQKKRMNLSRDTFWPVPVGRSKKEQAALWFQGLAGNETLEQLVKRKVPIFNKREDIFDVLFEKDVPVSRAVWYIKMTAAYSSLGAEMKLSAKKKQATDPSFEWTVALTKFMQETVWRISNDSSHRHDSISSNKQNSFTEETVQELSRWKYISELSSWLYQENLLERHEFLRWLIERIETSKPDEKSLVLYLPLALKYLNDISRCVYLARPLIQFCCQKFSSSYEIYQKFLSSSAATAKPNKDSTLESMETNEDDDVFNIATPSAGIKIKQEKREGDEPPVRHVAGRKRSKSGSLTVTIEDSAINPPTASTTNQSTIGGMSSSCKHHSSLLLQLSCIIQIIAIHCPTAFINASLTGGVGGGGGGGGVGSKGLRDSSGGGSKVSTPLDRLPMPLSEMPLPKRVSELGKKFESALVVAENEIRQRTRAAETGWSSMAIADLQTSNISQIVQQILKVLKELDKHSFTTTKSHSTLSTLYVKIIQIQKPNEFSLQFKDALCMLLCQWAVTPHRHGYHRPLVAARLLKRIQLDIATGLVTTDLNMLDDYWETPDNPQGTATGNSDMGSYPFQQTLFKFLSTHAPLPDSLYFPLKDNEPFKHLITLFSELIDLKVFSYTLYLSTLIARGDTTLPIIPSLPFFRGEGNNPPPSPALSEPGELSLAIPLSLLPNYDRNSVKKFDGGQQKRSMMLDVKQEERTISPSLPPSFDHQDSLLAGLSHYGSSSFGHEMAIKMEENPSLRQMRADKLERLAMLDEDPQLVDFGSHPSSPIKPDDFNFSLNFLQASPDQSLDESLAPPTATSRTPVGPAPSTKLNTKANKLLIYAAYFPAHLLDSSSQVRNQRSVVLCGTGHQGIRVEEEVKRLQEEADTLLKELFSKASPVLPDDVNKFLDEFKLLPAFEQNCIGVSASQFILGQTSGGVSHHFPSCSQLVFVTEMLRICGSYSQLIQLIVEILTYEEEKKEGQRSQSMYVALPQSLSLVIVDLLWLYYPILLLSLHDTLVVYERLYRLIEGLLKQTKFSAVQKKVFLFLKHLQTQCYYLERTYPVLPNFFNNYCVPCVEDLPYTPSSMLPNLLKNCMDNSVFIGARPGDSEQALSSVVNYSTSKSSFFIVCEIFAIVLQRQTSLLTLTTLAHISSELSIFIDLLPKELLGAVRALCIPNAIYKACATGYSQLAQKSNVLSTPGMHKNFVTFIGLLLAFNCFTIHDIITYIIKPMFKVYLLHPQQSSQANQGTLSLQFVSLLLRHILVDKYIRGEVNDDGVNIVYPPFVSHYLLAKSKELSFDVVLNLLKELLKLSKDTLRSSRGTTWGGKTGMSILVESFPSGSQGNEAALIKLRETMELIAEQDWVREQCSKQDSKQLLHVEKLGDASLSPAQAQYLLHLLIPYCPEDTVKRINESSGSLPPFMTHPEQTVDRILKNLDQWTLHNALLHLNLNINSSLHLHSIDHLSQSVIQVFEDSCTEEWTEDSSSQVDGAYCPSIWLVTPLVSELPKSVLGKILKSAGNVLGKGQWWNLDRQQERRRSTRASITPTTPNPKTGLQWQQPFLELVLACMNSNHSNHEELLGPLQKQLTTFLTAFEKDSFPADEQNKSMLYTALKLRLGLVGSMLPSVCSVCESNVLDWVSLLIPLICSGAVDRQPDNSELFTNCLDMLSALLQALSPDFHMCVFSGGEEGKKSYIMCIKKMKSDLASSKSTCKQEIQQLFPLPQKLYEVTVVKPPSAFSQQFRIPEKVQGLRVQEVKEISPWEIIEGIKNSGPFQLSWFGATRIKRKPLKYLEQEKQIQHHTHQHFLSNSGHLLGGSGPSTSRHSVFLPDSNDSTNGAIGGGGGGGGVSSDSGDNAIPPGAASTAGGTRASVGGTGEGSGLDNKAEILLQINKMNREQQPSLTTQPGPLPPTFHTTGQVGVSNTPHQLTQQQPMQRQIPHGMMQQHSAAQMMRPPPHFLQRQLEYMTPEQRNHFMSLPNEEKRVYLSNLQRTFRERRMLEQQQQQQQQQQLMFRHPMHPRPMQVAPPMQMTQVLQQRMMPRYGPQHMGPPQMHHSGGYMMPGHHPAMFRQPPPGPMYTMHRPPMHHNLPPHHQ
Length2156
PositionKinase
OrganismAmphimedon queenslandica (Sponge)
KingdomMetazoa
LineageEukaryota> Metazoa> Porifera> Demospongiae> Heteroscleromorpha> Haplosclerida> Niphatidae> Amphimedon.
Aromaticity0.08
Grand average of hydropathy-0.339
Instability index53.42
Isoelectric point7.91
Molecular weight241696.89
Publications
PubMed=20686567

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13665
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.83|      15|      15|    2122|    2136|       1
---------------------------------------------------------------------------
 2005- 2019 (28.91/14.65)	MMQQHSAAQMMRPPP
 2101- 2113 (23.71/10.40)	MMPRYGP.QHMGPP.
 2122- 2136 (34.19/18.96)	MMPGHHPAMFRQPPP
 2139- 2153 (30.02/15.56)	MYTMHRPPMHHNLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|    1046.90|     362|    1460|      59|     492|       2
---------------------------------------------------------------------------
   59-  489 (538.18/552.33)	HLRSADFISR.LNQIVDTKKRTAWGQDSQKKRMNLSRDTFWPVP..........VGRSKKEQAALWFQGLAGNETLEQLVKRkvpifNKREDIfdvlfEKDVPVSRAV..W...YIKMT.AAYSS..LGAEMKLSAKKKQATdpSFewtvaLTKFmqetvwriSndsshrHDSISSNKQNSFTEETVQELsRWKYI.SELSSW..LYQENLLERHEFLRWLIERIETSK.PDEKSLVL....YLPLALKYLN.DISRCVY....LARPLIQFCCQKFSSSyeiyqkfLSSSAATAK.........PNKdsTLEsmetnedddVFNIATPSA............GIKIkQEKREGdePPVRHVAGRKRS.............KSGSLTVTIEDSAINPPTAS...TTNQSTIGGMSSSCKHHsSLLLqlsciiqiiaihcPTAfiNASLTGGVGGGGGGGGVGSK...............GLRDSSGG...GSKVST.........PLDRLPMP.LSEM..PLPKRVSELG
 1520- 1980 (508.72/366.50)	HLHSIDHLSQsVIQVFEDSCTEEWTEDSSSQVDGAYCPSIWLVTplvselpksvLGKILKSAGNVLGKGQWWNLDRQQERRR.....STRASI.....TPTTPNPKTGlqWqqpFLELVlACMNSnhSNHEELLGPLQKQLT..TF.....LTAF........E......KDSFPADEQNKSMLYTALKL.RLGLVgSMLPSVcsVCESNVLDWVSLLIPLICSGAVDRqPDNSELFTncldMLSALLQALSpDFHMCVFsggeEGKKSYIMCIKKMKSD.......LASSKSTCKqeiqqlfplPQK..LYE.........VTVVKPPSAfsqqfripekvqGLRV.QEVKEI..SPWEIIEGIKNSgpfqlswfgatriKRKPLKYLEQEKQIQHHTHQhflSNSGHLLGGSGPSTSRH.SVFL.............PDS..NDSTNGAIGGGGGGGGVSSDsgdnaippgaastagGTRASVGGtgeGSGLDNkaeillqinKMNREQQPsLTTQpgPLPPTFHTTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     397.53|     127|     141|    1214|    1350|       3
---------------------------------------------------------------------------
 1214- 1350 (199.03/170.88)	SSELS..IFIDLLpKELLGAVR.ALCIPNAIYKACATGYSQLaqksnVLSTP.GMHKNFVTFIGLLLAFNCFTIHDIITYIIKPMFKVYLLHPQQSSQANQGTLSLQFV.SLLLRHILVDKYIRgeVNDDGVNIvyPPFVSH
 1356- 1487 (198.49/140.92)	SKELSfdVVLNLL.KELLKLSKdTLRSSRGTTWGGKTGMSIL.....VESFPsGSQGNEAALIKLRETMELIAEQDWVREQCSKQDSKQLLHVEKLGDASLSPAQAQYLlHLLIPYCPEDTVKR..INESSGSL..PPFMTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.90|      22|      28|     648|     669|       4
---------------------------------------------------------------------------
  648-  669 (41.50/29.27)	PFQQ..TLFKFLSTHAPLPDSLYF
  676-  699 (34.40/22.71)	PFKHliTLFSELIDLKVFSYTLYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.47|      39|     139|     711|     753|       6
---------------------------------------------------------------------------
  711-  753 (63.91/36.34)	PIIP.....SLPFFRGegnNPPPS..PALSEPGELSlAIPLSLLPNYDRN
  848-  893 (59.56/24.97)	PIKPddfnfSLNFLQA...SPDQSldESLAPPTATS.RTPVGPAPSTKLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.32|      15|      19|    2020|    2034|       7
---------------------------------------------------------------------------
 2020- 2034 (28.02/15.65)	HFLQRQLE....YMTPEQR
 2036- 2054 (17.55/ 6.74)	HFMSLPNEekrvYLSNLQR
 2055- 2069 (21.75/10.32)	TFRERRML....EQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.36|      14|     136|    1004|    1026|      10
---------------------------------------------------------------------------
  997- 1016 (19.91/29.57)	GGVSHHFPscsqlvFVTEML
 1020- 1033 (22.44/ 6.62)	GSYSQLIQ......LIVEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.11|      16|      35|    1071|    1086|      17
---------------------------------------------------------------------------
 1066- 1084 (20.82/ 9.16)	LYypiLLLSLHDTLVVY.ER
 1105- 1121 (23.29/11.07)	VF...LFLKHLQTQCYYlER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13665 with Med12 domain of Kingdom Metazoa
Unable to open file!