<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13642

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMYLSCFDEECELWLPNLPLEGVSNKVCLHCVITGWVGTWNCMKMAASESEATQAFPNPPSILYKLYTDEAVESGSAPKPPPPVQGHYQMFGAPFNTGDAMIRSLEEQNVQRLYPQQYDKKVELKKLNRSILICFLELLDILIDNPSSPERNDKIKDLSILFINMHHLINEYRPHQARETLRVVLERQKRQRDEMIQQITRAMEKAQTILKTCDGSLKQLITTLPAAEDEQEEMETSQANEKTDQNPVTLDSFVDSQDRDLIKYVDTFK
Length268
PositionMiddle
OrganismAmphimedon queenslandica (Sponge)
KingdomMetazoa
LineageEukaryota> Metazoa> Porifera> Demospongiae> Heteroscleromorpha> Haplosclerida> Niphatidae> Amphimedon.
Aromaticity0.07
Grand average of hydropathy-0.522
Instability index57.26
Isoelectric point4.97
Molecular weight30825.81
Publications
PubMed=20686567

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13642
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.63|      21|      23|      46|      66|       1
---------------------------------------------------------------------------
   46-   66 (37.08/20.24)	ASESEATQAFPNPPSILYKLY
   70-   90 (40.55/22.67)	AVESGSAPKPPPPVQGHYQMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.28|      23|      24|     201|     223|       2
---------------------------------------------------------------------------
  176-  198 (31.79/18.06)	ARETLRVVLERQKRQRD..EMIQQI
  201-  223 (34.78/20.33)	AMEKAQTILKTCDGSLK..QLITTL
  225-  249 (29.71/16.48)	AAEDEQEEMETSQANEKtdQNPVTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.98|      20|      28|     114|     141|       3
---------------------------------------------------------------------------
  114-  137 (23.79/38.66)	PQQYDKKVELKKLnrSILicFLEL
  145-  164 (35.20/20.68)	PSSPERNDKIKDL..SIL..FINM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13642 with Med7 domain of Kingdom Metazoa
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