<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13615
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAAGPSSKLEELEDRLESFIENLRVVGVIAGNFQQNGQGVLNERLNTAVEHMRMLDREKDNFSDIDIPVQVLNYVDDGRNPDLFTQHQLEKTLGDYQAVQRKTETYKMFRDELVRQLESSFPVEVNAYLAHRQMTRPSS |
Length | 139 |
Position | Middle |
Organism | Amphimedon queenslandica (Sponge) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Porifera> Demospongiae> Heteroscleromorpha>
Haplosclerida> Niphatidae> Amphimedon.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.660 |
Instability index | 31.31 |
Isoelectric point | 4.95 |
Molecular weight | 16029.76 |
Publications | PubMed=20686567
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13615
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.37| 22| 26| 12| 33| 1
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12- 33 (36.12/28.01) LEDRLESFIENLRVVGVIAGNF
41- 62 (38.26/30.07) LNERLNTAVEHMRMLDREKDNF
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