<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13602

Description Uncharacterized protein
SequenceMDYRPPPGLSRPAPPQRAVSGSYAVQQGLRRPPLPSRLQNVRSVSQPGGMVDVPGDGSRVDVRNTTAFLSNSNATTNLPGAINPTAQDDSERPLKRAKIGGHGFRGTGEGGEVATDRAHRTVPGSPLPTLPAPTTATRRNAQQTTTTRPGVDRAARKANGLEPPSIATRVPQPKNVADFSPWHGQHPEDTMSEIVVKQGYSDKAAGPNSTETNSARTTIWPNLSQKNMMGLQTLSYLFTSVMEKRQLLGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPDVPLRKQSRTIPHGIRGKSLMEQCLSKDIPMPRAVWLAKCVGANELRAFRRKGVSGAAAASGESKWVMEWTVHVEQFLEGVIASCGQSDWQAKMDYAVKLATSFYTERLLERDHYLYWIVSSFAEASMETLPTWLIMVQLYWKDILAFGRRGRQLAEAALENLHQISMRKTSIHDALKYRLKKLIAIMAVTNRGCLVVPRTWEKYKYLLVPRMTGTTSHAHNVARRNTRLTAPLLQTPRNIQCALLKLYAVLDTTGLKLDLAELTADCIAIVPDVPRLVSAILDWSASMYRTGTDRIYLAAGVVAQLRRAHDTDAAIMQYLRSGKSTALGIVDVHRVIAELVRTEAFSTGRYLQWLMTSGALSVNNGVSPATSLLNALPTNSLQPHLLNTRNMLLRRLGLLKNESRQIDEIFQRSDPARWAADVEQQEVATAVDALSVSAKLELALRITSQAVASGKLGHMTLEHFCIVREIIERCDDARALADLAQSAMHCDDTILLATVCDTLNMHAKSLAVIGRSNGSLVQIFERYSTVRSQQPLDRAFILALRALSQRFPERAHMVKLLDQDMTICEQQNSMVVCSPASDSIVNMQASTLASDDDIDAVFASGNNMDEQLMQRVFARVVQRLNKTMQPDATAPSKVCGWLSQLRAVVVDPASFEQMAVSHVQACLENAGEDMAPCKIIVALVAGGCMNFDTLVNTAIATKKAASACLAIRLLTSRTAACEGLHPTEAYRYHIQQELYCSEKAEVVMSALVSAMEDSNFPAEDPAVVDLVLRYSVDHHDAGYRALASHPRSTALLANCSRITTKLLSLGNNPAAIDSRLDAKSIIDQATPLSIVQCSAALRLYSIVHPDAAEHVQKAVLEAVVAGSEVWPQLLESAGNETVRGIYGWAKEQVLNNALPSSTSSEPLDEASRSRNLDILDVAIHAAKEQDVSAVIATVTDKLRAFEIQISSSDSVGSLKSLLASLHILLHLAVLYGSPTSESSGSTDRNDSQALIGLLTSLCALLIHPKLQTQTSLLEYIYDVASALSDSLQDTVLSNLAKNVPTKDPRLASILGSTANPDAWLAIVSNPSGSMTGAAQGARAGLMRSASGVGTSASGLGIQQLSPQQMQQAQFTGRPLPLNQQQGQAAHLQQAQMQAAQRSPGQQFSPSFAKPGGAVGGSVRSVASGSGGETKIAPYPLRRWEIMSDATPVVGGNDTSLSLGLFGARKV
Length1492
PositionKinase
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.157
Instability index42.28
Isoelectric point8.81
Molecular weight161598.68
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13602
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      36|      68|    1054|    1094|       1
---------------------------------------------------------------------------
 1054- 1094 (59.57/40.42)	LR.YSVDHHDAgyralASHPRSTALLA..NCSRITTKLL.SLGNN
 1123- 1162 (51.70/25.66)	LRlYSIVHPDA.....AEHVQKAVLEAvvAGSEVWPQLLeSAGNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.35|      28|      68|      53|      80|       2
---------------------------------------------------------------------------
   47-   78 (44.51/24.13)	PG.....................................gmvdVPGDGSRVDVRNTTAFLSNSNATTNL
   79-  147 (31.84/15.11)	PGainptaqddserplkrakigghgfrgtgeggevatdrahrtVPGSPLPTLPAPTTATRRNAQQTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.07|      49|      68|     673|     721|       3
---------------------------------------------------------------------------
  673-  721 (82.85/67.99)	MLLRRLGLLKNESRQI.DEIFQRSDPARWAADVEQQE........VATAVDALSVSAK
  733-  790 (75.22/60.87)	VASGKLGHMTLEHFCIvREIIERCDDARALADLAQSAmhcddtilLATVCDTLNMHAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.04|      13|      14|     814|     826|       4
---------------------------------------------------------------------------
  814-  826 (22.21/14.31)	SQQPLDRAFILAL
  830-  842 (23.83/15.95)	SQRFPERAHMVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.37|      57|      70|     205|     265|       5
---------------------------------------------------------------------------
  205-  265 (87.96/65.17)	AGPNSTETNSARtTIWPNLSQKNMMgLQTLSYLFTsvMEKRQLLGKCTAPSTFKPPPRVTV
  278-  334 (101.41/60.36)	ANPDVPLRKQSR.TIPHGIRGKSLM.EQCLSKDIP..MPRAVWLAKCVGANELRAFRRKGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.72|      50|      68|    1220|    1272|       6
---------------------------------------------------------------------------
 1220- 1272 (78.55/51.79)	VTDKLrafEIQISSSDSVGSLKSLLA.SLH..ILLHLA..VLYGSPTSES.SGSTDRND
 1288- 1343 (64.17/35.04)	IHPKL...QTQTSLLEYIYDVASALSdSLQdtVLSNLAknVPTKDPRLASiLGSTANPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.26|      20|      21|    1375|    1395|       7
---------------------------------------------------------------------------
 1375- 1395 (31.92/25.42)	GTSASgLGIQQ.....LSPQQMQQAQ
 1398- 1422 (31.34/19.10)	GRPLP.LNQQQgqaahLQQAQMQAAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.60|      18|      34|    1440|    1457|       8
---------------------------------------------------------------------------
 1440- 1457 (30.60/21.17)	VGGSVRSVASGSGGETKI
 1475- 1492 (31.00/21.55)	VGGNDTSLSLGLFGARKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.11|      11|      22|     336|     346|       9
---------------------------------------------------------------------------
  336-  346 (20.43/12.26)	GAAAASGESKW
  360-  370 (22.67/14.52)	GVIASCGQSDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.26|      30|      35|     518|     550|      15
---------------------------------------------------------------------------
  518-  550 (41.52/33.54)	PRNIQcALLKLYAVLDTTGlkLDLAELTADCIA
  556-  585 (52.75/30.53)	PRLVS.AILDWSASMYRTG..TDRIYLAAGVVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.38|      15|      23|       3|      17|      17
---------------------------------------------------------------------------
    3-   17 (32.00/14.79)	YRPPPGLSRPAPPQR
   23-   37 (29.38/13.03)	YAVQQGLRRPPLPSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13602 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASGLGIQQLSPQQMQQAQFTGRPLPLNQQQGQAAHLQQAQMQAAQRSPGQQFSPSFAKPGG
2) MDYRPPPGLSRPAPPQRAVSGSYAVQQGLRRPPLPSRLQNVRSVSQPGGMVDVPGDGSRVDVRNTTAFLSNSNATTNLPGAINPTAQDDSERPLKRAKIGGHGFRGTGEGGEVATDRAHRTVPGSPLPTLPAPTTATRRNAQQTTTTRPGVDRAARKANGLEPPSIATRVPQPKNVADFSPWHGQHPEDTMSEIVVKQGYSDKAAGPNSTETNSARTTIWPNLS
1378
1
1438
224










Molecular Recognition Features






MoRF SequenceStartStop




1) KRAKI
2) MDYRPPPGLSR
3) SYAVQQGLRRPPL
4) YPLRRW
95
1
22
1460
99
11
34
1465