<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13600

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMKAQLLTVSLRELQQRYPLDGKAIATLLVSFRARPSGMNEPLFYSYATLFLKDKLITSADLLLALFDSSVARSGHSGNPISTRTFGQPCYEERMFTIMTQIHLSTELPSSAIDVHSLVHAVVKWLHHVCEYEMGRQLEGAGIDTMHPCSLGAYEALGSLAISILGNQGIRNVAKQSWWRAGRAQIVEEMQNYDANILQWMQSQLAGRLRALTGMPPYIKTDGKGRPVLTDDQILEAIPEVPTMNSRAGLFLWLNAALAARPLTDDMTLLGYLHARYPGNVQSLIVDLLVASFDNLTNAMLRKEIRQNVKVIRSFICNKLPTLIAMLCGSIGEQITPEACIQMALIPGGLISMTPLPPISNGATDIEESLKGTRLEFLQACALHGLVAESTIAAILRGPIALPRVTKYSKETLVAQCANNPSRLAPLIDDLNGMQGNAGAISGCVVETISNLCMSKDTMSLKTVCNELIKRIAYMDVVMQYTQPQMLLLPLCNLLNEWMHDQDQTEFTPSYEEFASILLLTLATMHRYEIQWPDIGVLEDSFIARLLDDMSCSKPPSELPDEQGSQLAKWIEGLFAVDDSGETIGIGDDVMRQCSPQNFYLLVPTLFEQSVLACRSNALAINTFKGGLELLLEPFLLPSLIMGLGWLVEHSWEDHNDVDLLLQVLEKLLKPSSTSQETQAMHRTILSMVATPWHDSLQELQRRQPDKKKVAELSALLTPYLSNQRTLSCRRSELNDWIQNEGALKARVQQSLRELIRWASTSTNPPDPPPRYAHKLFAVACQALSPEKLLSIILGEITATDFSTIPTALDVCASMICAPTALSAATHQPGSAIALSPVRTLRNHIRHLVSEPQALLTRLQRNAEALVQLSRRIESQLSIAQMPALTIPLQMQDQAADQMMQDLGLDIPATGDANNNAIGAGASGSIDLGPEFAGLSGISQSQAQELVELANADGASGTAAGGMDLGDQGVFGGLLDMNSGTQGDGSGGQEGSQGGMNNDDDIFAGLDMIGDFEMD
Length1014
PositionTail
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.021
Instability index47.42
Isoelectric point4.95
Molecular weight110610.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13600
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.81|      25|      30|     952|     976|       1
---------------------------------------------------------------------------
  918-  937 (32.06/16.03)	.GA.G...ASGSIDLGPE..FAGLSGI
  952-  976 (49.44/28.73)	DGASG..TAAGGMDLGDQGVFGGLLDM
  983- 1007 (40.31/22.05)	DGSGGqeGSQGGMN.NDDDIFAG.LDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.08|      32|      35|     197|     231|       2
---------------------------------------------------------------------------
  197-  231 (50.43/41.52)	LQWMQSQLAGRLRAltGMPPYIKTDGKGRPvLTDD
  234-  265 (55.65/34.84)	LEAIPEVPTMNSRA..GLFLWLNAALAARP.LTDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.65|      83|     359|     356|     454|       3
---------------------------------------------------------------------------
  320-  423 (117.00/88.48)	PTLIAMLCGSIG..........EQItPEACIQ.........................................................................................................................................................................................................................................................malipgglismtplPPISNGATdieESLKGTRL.EFLQ.ACALHGLVAEStIAAILR......GPIALPrvTKYSKETLVAQC.ANNPSRL
  424-  454 ( 1.76/ 9.98)	APLIDDLNGMQGnagaisgcvvETI.SNLCMS....................................................................................................................................................................................................................................................................................................................................................
  718-  788 (79.90/43.74)	................................kdtmslktvcnelikriaymdvvmqytqpqmlllplcnllnewmhdqdqteftpsyeefasillltlatmhryeiqwpdigvledsfiarllddmscskppselpdeqgsqlakwieglfavddsgetigigddvmrqcspqnfyllvptlfeqsvlacrsnalaintfkgglelllepfllpslimglgwlvehswedhndvdlllqvlekllkpsstsqetqamhrtilsmvatpwhdslqelqrrqpdkkkvaelsalltPYLSNQRT...LSCRRSELnDWIQnEGALKARVQQS.LRELIRwaststNPPDPP..PRYAHKLFAVACqALSPEKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.45|      22|      32|     814|     844|       4
---------------------------------------------------------------------------
  814-  835 (37.47/42.60)	MICAPTALSAATHQPGSA.IALS
  847-  869 (29.98/12.20)	LVSEPQALLTRLQRNAEAlVQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.85|      26|     224|     290|     315|       5
---------------------------------------------------------------------------
  290-  315 (45.75/35.32)	ASFDNLTNA.MLRKEIR.QNVKVIR.SFI
  514-  542 (33.09/23.35)	ASILLLTLAtMHRYEIQwPDIGVLEdSFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.01|      10|      24|     458|     467|       6
---------------------------------------------------------------------------
  458-  467 (18.38/10.32)	MSLKTVCNEL
  485-  494 (18.62/10.55)	MLLLPLCNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      18|     683|       9|      27|       8
---------------------------------------------------------------------------
    9-   27 (28.76/20.78)	SLRELQQRYPlDGKAIATL
  695-  712 (32.36/18.93)	SLQELQRRQP.DKKKVAEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13600 with Med5 domain of Kingdom Fungi
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