<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13598

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEHQKDARLQDLKKDRSNAQGGDALHTQDAFNGQNSASQKAAANGQVTTSEATGLPTPPELDQSWRDGPDNKPMGVLIERLAQQCFTDLGTTLKTMAEIPESTQANGVVPHAVDTSVASLTKKRTLMDFAHNQRDRFIKTLVLSDWARNEQDMARLVDIKVWQERQLGAQVQAISSIGNTKHNMQGAKIPNPNLDGALELLATGTSRMPDLGYLPPKKLSAKQLLRTLQDMNVALATRLNLHEELPYYFNDLSIANGRATFRVADEFEVDLSLGDEDPSTPFWFIDMRFLFSPTPDITDDVSRMELEKRVNIALASESKLQGCYDLLHNFVLTHKINVLRDQASQLLREKWFECLFVEMKKRVLIVQYWSDLAGPKSWLEIGVSTGKQNRKGSKPANAQLSVRWFRRGQEVLDDSPSIDWKTLNVEQVLGTVIAKHTSWDLRNTKNGLVKLAGPNSKLDITLDACADTPEDCSLALGLPGMRTPYIVRKEVVTGKWAISPPTMLAARAERLMNADLKADPAVQLAQMLCGTNQERFGKAADLAGWISVSSRTLAPQNNLKALFGADTVSRSIYKCQRGWSDSWALVATFGLSGDKWWAARLEPKLDARGTSTGSIFAEARRISIPSDLLALSGVARSLLIRIEKLAVAQISLAVVTQDLDSKRIPYKIENTASLTPAERSRGERSSAASAEPAVVLDSASFFDDAKSDPLRKPFKDGSIRLTHDRNITSPPATDGSRAEVTHCLRLTVRHGVLNHLQEYLLTKPRDVDMFMNDRGALALRVRVQFGQPCVSVLQARLKSCKRLDAYLVALARYSFVCTHLSLTRVTFTYPSNPDLSATVRFSTNPNAPPSADLKLHPTDSNPHQRVRVIALRTFNLAPLDPKSFTALLYTLRTSVSLNIAYSTISALPPLGSMHIHPHHLLAYLWTYSAPLPGAGAQFKIQWRPNVGEKKKGVWHIMTQLSKPNKGSGELREEVRMGIAEVCLKKGSGRIGNGTSIVVEDGLVGEVIRELDRVCREGGEAVDGKKEEEVKDVKVDTAAGSRPSGSGNGNGHRGSVTNGNGNANGNGRLKQEIIELD
Length1076
PositionTail
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.354
Instability index32.16
Isoelectric point9.02
Molecular weight118476.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.46|      26|      33|     919|     951|       1
---------------------------------------------------------------------------
  919-  948 (39.87/39.53)	HLLAYLwtySAPLPGAGaQFKIQWRPNVGE
  955-  980 (43.58/21.04)	HIMTQL...SKPNKGSG.ELREEVRMGIAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.11|      47|      50|     305|     352|       3
---------------------------------------------------------------------------
  305-  352 (76.84/61.21)	ELEKRVNIALASeSKLQGCYDLLHNFVLTHKINVL.RDQASQLLREKWF
  358-  405 (80.27/59.05)	EMKKRVLIVQYW.SDLAGPKSWLEIGVSTGKQNRKgSKPANAQLSVRWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.30|      25|      33|     710|     734|       5
---------------------------------------------------------------------------
  710-  734 (43.46/23.38)	LRKPFKDGSIRLTHDRNITSPPATD
  744-  768 (41.84/22.28)	LRLTVRHGVLNHLQEYLLTKPRDVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.13|      11|      75|     139|     153|       9
---------------------------------------------------------------------------
  126-  137 (17.36/ 8.81)	LMDFAHNQRDrF
  143-  153 (21.77/ 6.38)	LSDWARNEQD.M
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.65|      43|      47|     474|     519|      11
---------------------------------------------------------------------------
  474-  519 (64.49/57.24)	LALGLPGMRTPYIVRKEVVTGkWAISPPTMLAARAErlMNADLKAD
  524-  566 (73.16/52.62)	LAQMLCGTNQERFGKAADLAG.WISVSSRTLAPQNN..LKALFGAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13598 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKEEEVKDVKVDTAAGSRPSGSGNGNGHRGSVTNGNGNANGNGRLKQE
2) MEHQKDARLQDLKKDRSNAQGGDALHTQDAFNGQNSASQKAAANGQVTTSEATGLPTPPELDQSWRDGPDNKPM
1024
1
1071
74










Molecular Recognition Features






MoRF SequenceStartStop




1) MEHQKDARLQDLKKDR
2) NGRLKQEIIELD
1
1065
16
1076