<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13592

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKSCTTNIHVVEDLAETALLLYRLRDERAGSTQKLKEARKAVSHLRREKVLCAIVEQDIYIFGDVNPEHTLELENTYDLVEEGTVCSQDETISVDTKDIFLDAVEHAIAFSLAVDPAITYVAPWTWLYHDSEAENGSDADSGSIIKMYAEYTPTAALLLVPEILPASWLPIGHADAQVGSHIILAPRGIPARRIAEARRRVSPDNAWKAKVSEVLQLDAIQTDDDTVWISVELQDSAGLCCLWPAELCLAPFTATNLDFCATTRQSDWRRWLVGLEEEDAFRNPLAVAEEWFKGAGEREQAVQNAVKASTGDPHSSQNLVSTAANDEEAMTSPPFMQRALDQQTAVSGIYPTPPDGMAQAPQTAQINLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSLDREDFELNQEDLFGDNSGGVEFGEDAVDDADFNFFDEPDDEPEQGTVASTEMDDESTHEHELDPVIAQDTVTESQAALDDIPAATAVDSAVSENLTLPTCNDIAGDVILAVGSDDSRFATHTSEPEKALSPFGIRERLLPPPVPASLANTDSKDSAKYRKHSTFAPIVFKDSFNLGPKYADTRLEDDEAQRPIVKSKVPNINLPPVKKKSRLLRQKADMEYRMTDPNSESEEDSYESASSDSDDELPPKLPWDTRKRKRPSDDDRLQPLASSMERMLSDDDPGDDSEATESQHDADTMLEKCLPRASSGGISVSFKNPFDNYSGCGPKNASGEESGDSIRNVEELFSLRKEDLIYVAQIVHEQAMSMSRSSVAEQDLFSNGGPDPEKAQCGRMSIAKAVESVFPDFEICDLVQLAATRDQAPRLTVPVKTPQGQPRMPQRSDSQIVLGPDYFPLPSPYVRIQRGADDWEMTSTCLSFWETLGLGPTNGPKNVRAFCVFPFNEDLQHLVEQFMGDLGTSYENCKLGSYVHLRNVSDASLDSFEDGMAPVEVNEEGDSVEGLLKAYATTCAELGKVLSTIGHEESDRTIVVYMLNPFSGRQALQHLCACFWVLFKAYRDNVPKALRNQCGSDIVLQVLPMKLVASFDELVMPEAKEMALLAREVYDRCPPSSSHNSETLSALPILAAPSVELANAAPKRIAFQLAAEPPSDLLHEGSILHLAYACSQDGHWLTVAWIDNTGQHQSTASFCLRGKTFSEVAEDVWGRTREILAARQVTWRVFIVTPDAMDTSLSQCWRSITSRRRPHPLCVTLLSVQLDPILHLSPPAPPSDTQITWPTADGGFLTPASTPQAGNLTSSPNPGGDSTAPPTPAPSETMTAASIAENDPDAYLTDLTDETWGVLLSPKLAPFASSFPGQANGALFRRGDPSPGEALPSLGVSVHWTIQVKPSGGVDDGSVKQAELTCREVLKMYRGLSVLTKARGLDGGRRGTEWVTPVHVAMVVRGVEGLEGFLEKGGET
Length1425
PositionKinase
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.07
Grand average of hydropathy-0.387
Instability index47.78
Isoelectric point4.54
Molecular weight155561.57
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13592
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.37|      47|     159|     936|    1006|       1
---------------------------------------------------------------------------
  955- 1006 (68.90/75.03)	PVEVNEEGdSVEGLlkAYAttCAELGKVLST..IGHEESDRTIVVYML..NPFS.......GR
 1115- 1172 (71.47/31.81)	PSDLLHEG.SILHL..AYA..CSQDGHWLTVawIDNTGQHQSTASFCLrgKTFSevaedvwGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.78|      16|      18|     322|     337|       2
---------------------------------------------------------------------------
  319-  334 (24.01/12.45)	SQNLVSTAANDEEAMT
  335-  350 (27.78/15.54)	SPPFMQRALDQQTAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.88|      10|     160|     722|     737|       4
---------------------------------------------------------------------------
  577-  586 (20.49/ 6.20)	FKDSFN....LGPK
  723-  736 (17.39/18.31)	FKNPFDnysgCGPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.84|      53|      55|     605|     659|       8
---------------------------------------------------------------------------
  437-  472 (25.60/ 8.75)	.......................DADFNFFDePDDEPEQGTV..ASTEMDDesthehELDP...
  605-  659 (90.49/58.82)	KVPNIN..LPPVkkKSRLLRQKADMEYRMTD.PNSESEEDSYESASSDSDD......ELPPKLP
  666-  712 (75.75/43.38)	KRPSDDdrLQPL..ASSMERMLSD.....DD.PGDDSE..ATES.QHDADT......MLEKCLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      15|      18|     274|     290|       9
---------------------------------------------------------------------------
  274-  290 (23.15/22.22)	WLVGL.EEEDAFRNplAV
  294-  309 (24.00/14.57)	WFKGAgEREQAVQN..AV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.77|      76|     604|     189|     271|      10
---------------------------------------------------------------------------
  189-  271 (119.07/84.78)	PRGIPARR..IAEARRRVSPDnawkAKVSEVLQLDAiqTDDDTVWISVELQDSAGLCCLwP....AELCLAP.FTATNLDFCATTR.QSDW
  793-  876 (118.70/65.61)	PEKAQCGRmsIAKAVESVFPD....FEICDLVQLAA..TRDQAPRLTVPVKTPQGQPRM.PqrsdSQIVLGPdYFPLPSPYVRIQRgADDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.53|      22|      22|     360|     381|      11
---------------------------------------------------------------------------
  360-  381 (36.96/21.54)	MAQAPQTAQINLGATPSVAHTD
  384-  405 (38.56/22.80)	MSGVEMTSNTNDHAQSNGSDPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.47|      80|    1144|      92|     178|      12
---------------------------------------------------------------------------
   92-  178 (127.95/92.00)	DETISVDTKD.IFLDAVEHAIAFSLAVDP.......AITYVAPWTWLYHDSEAENGSDAdsgSIIKMYAEytpTAALLLVPEILP.ASWLPiGHAD
 1237- 1325 (130.52/75.02)	DTQITWPTADgGFLTPASTPQAGNLTSSPnpggdstAPPTPAPSETMTAASIAENDPDA...YLTDLTDE...TWGVLLSPKLAPfASSFP.GQAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13592 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PAPPSDTQITWPTADGGFLTPASTPQAGNLTSSPNPGGDSTAPPTPAPSETMTAASIAENDPDA
2) REQAVQNAVKASTGDPHSSQNLVSTAANDEEAMTSPPFMQRALDQQTAVSGIYPTPPDGMAQAPQTAQINLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSLDREDFELNQEDLFGDNSGGVEFGEDAVDDADFNFFDEPDDEPEQGTVASTEMDDESTHEHELDPVIAQDTVTESQAALDDIPAAT
3) YADTRLEDDEAQRPIVKSKVPNINLPPVKKKSRLLRQKADMEYRMTDPNSESEEDSYESASSDSDDELPPKLPWDTRKRKRPSDDDRLQPLASSMERMLSDDDPGDDSEATESQHDADTMLEKCL
1232
301
587
1295
493
711










Molecular Recognition Features






MoRF SequenceStartStop




1) AKYRKHSTF
2) FGEDAVDDADFNFFDEPD
3) PPVKKKSRLL
4) REDFELNQEDLFG
564
430
612
410
572
447
621
422