<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13589

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDSNQIEEASMVDAAMMDPTMEDLFGEAANDLAVGDLGVGLPPIPLPPSLMLRIAELQHKGCCTKLAWSNTGSIARISEDGTQVTFHVMRRSRKTGQWCVGRASGYPIKASEGREFVHIQFSGIGIDLAVVDDLGIVHMHTLTGGLGRMVPAEGNISNDITRNELHAVVGMHWLAVWTTEFTGPYIRPANKIGNKWEAQLQQRDQHSIKIHHPAMGRHAVLYITRSTELTLLYQNEGQGWQSTSIVIDEVRSSDQIISHAAMGEEGADLLVVTFDHSSRMRLYRVSIEWNATQHSRQAGMVYTLIAPTMEVHHLTASHHTRAQHAHSAQLTHLEIIPAVPEAAQTMPTAATILAVFTQTSVPSDANPSQNAYSIISRWRVESLMPTLHDSFKKLSNARADSNGVLNSTTVLRRESDIITNKPILSIKSQMFDTMLAFTSSDGSIDLRDRLTMDQLGPFGLPTTVSSLLQAGFDHLASTQNLHVALSADASGLATISASDNSLTARPMTFTHGWTPSTPSALLDNTPYLEAGTVCLARQYAFLCYNSMSNDEVLSLFPSPAPDPSLHTTFLTQIFKMVNRSPDISMHENARQQMAVLKEPIVPRVLSAQLSLGTEPITGNRNVAAQYAYIFLNLRHIGTALAHTISQKDLSRVSPEAVHSLRPLVRWSIDLMIHIVSALSQLRGSNPSTTSASPILPLLLASFSRALLRFQVLWVIKYLHLLQQIIPRLPTLAQRTELAATLELGTKSLPFKLPALEALLVDIDSAIRQVYSSGEVNAERRGEIEVGLICGGGGVPRELQGVIARLVDVGVGKVLDAEGTDVVKLCFWDATWLGIERVQTPPPRSSHTNGTHTSKTSPTEAVFPGDMEIGGRWGYDIIRKVPLTEGMVVRECRRCGAVMEDFSPERVRASPGWLGHAQKNCVCMNYWVCG
Length929
PositionTail
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.074
Instability index45.44
Isoelectric point6.35
Molecular weight101794.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13589
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.29|      46|      81|     781|     833|       1
---------------------------------------------------------------------------
  781-  833 (64.17/63.23)	GEIEVGlicG..GGGVPREL...QGVIARLVDvGVGKVLDAEGTDVVKLcfwDATWLG
  864-  914 (76.12/48.54)	GDMEIG...GrwGYDIIRKVpltEGMVVRECR.RCGAVMEDFSPERVRA...SPGWLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     365.44|     146|     197|     304|     498|       2
---------------------------------------------------------------------------
   81-  146 (56.78/17.86)	GTQVTFHVMRRSRKTgqwcvgrASGYPIKASEGREF.VHIQF..SGIGIDL...AVVDDLGIVHMHTLTGGL...............................................................................................................................
  269-  391 (92.86/109.13)	.......................................................................LLVVTFDHSSRMRLYRVSIEWNATQhsrqagmvytLIAPTMEVHH.LTASHHTrAQHAHSAQLTHLEIIPAVPEA...AQTMpTAATILAVFtqtsvPSDA.NPSqnaysiisrwrveslmptLHDSF
  403-  569 (215.80/153.36)	GVLNSTTVLRRESDI.......ITNKPILSIKSQMFdTMLAFtsSDGSIDLrdrLTMDQLGPFGLPTTVSSLLQAGFDHLASTQNLHVALSADASGlatisasdnsLTARPMTFTHgWTPSTPS.ALLDNTPYLEAGTVCLARQYAflcYNSM.SNDEVLSLF.....PSPApDPS..................LHTTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.17|      26|      35|     185|     210|       5
---------------------------------------------------------------------------
  185-  210 (45.38/24.26)	YIRPANKIGNKWEAQLQQRDQHSIKI
  222-  247 (43.79/23.20)	YITRSTELTLLYQNEGQGWQSTSIVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.81|      19|      40|     650|     668|       8
---------------------------------------------------------------------------
  650-  668 (33.75/22.04)	SRVSPEAVHSL......RPLVRWSI
  687-  711 (25.06/14.30)	STTSASPILPLllasfsRALLRFQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13589 with Med16 domain of Kingdom Fungi
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