<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13588

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSTSDGERSPKRQRLESYSPASPQPTVDTRHFVPPQTPPPSVRMSPSWTAHTLPAQPTGSGTSTTFPTPPSTAGYLGHMAGRGAGSEGGGDSGHQTPAGEDEGYARRDHDGDAEMTDRPESGIDGVSSVDAEHRRTDHEREGAGGDITAPVPGAGVLYKLSTAPIAISRPHPSQDLIQLYDLKRIQAAVARRDPVTGEKINVLRKSYANKVKKLGLEGLNKAQSNLHELEGLLDPMWNNDAGNGATLWENHCEPMRMDKADVQEDLLNKLDDALRMKPGRLPAKEHEQWKSMLGLDEAIAPAVATKGGNTPNAAKLSGTSAFAKTSPGAGARNSAPASPRSLSRPDRSNKRRRYDDTSYEGYQQGFEDDGYSTGGVDDTGRRGSGAKRQKRKDFASSANSPAFTNGSGSNGMVGVRSS
Length418
PositionHead
OrganismZymoseptoria tritici ST99CH_3D7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.907
Instability index56.00
Isoelectric point7.20
Molecular weight44549.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13588
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.57|      20|      20|     150|     169|       1
---------------------------------------------------------------------------
  150-  169 (34.66/23.09)	PVPGAGV..LYKLSTAPIAISR
  170-  191 (29.91/18.94)	PHPSQDLiqLYDLKRIQAAVAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.17|      17|      20|     217|     236|       2
---------------------------------------------------------------------------
  220-  236 (30.00/23.75)	NKAQSNLHEL.EGLLDPM
  238-  255 (28.17/13.02)	NNDAGNGATLwENHCEPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.36|      19|      20|     302|     320|       4
---------------------------------------------------------------------------
  302-  320 (31.47/15.67)	AVATKGGNTPNAAKLSGTS
  323-  341 (32.89/16.71)	AKTSPGAGARNSAPASPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.30|      12|      20|      29|      41|       5
---------------------------------------------------------------------------
   29-   41 (22.73/14.00)	TRHFVPPQtPPPS
   49-   60 (22.57/ 9.42)	TAHTLPAQ.PTGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.20|      16|      20|     110|     125|       6
---------------------------------------------------------------------------
  110-  125 (29.07/17.34)	DGDAEMTDRPESGIDG
  130-  145 (29.13/17.40)	DAEHRRTDHEREGAGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13588 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APAVATKGGNTPNAAKLSGTSAFAKTSPGAGARNSAPASPRSLSRPDRSNKRRRYDDTSYEGYQQGFEDDGYSTGGVDDTGRRGSGAKRQKRKDFASSANSPAFTNGSGSNGMVGVRSS
2) LLNKLDDALRMKPGRLPAKEHEQWKSMLGLDEA
3) MSTSDGERSPKRQRLESYSPASPQPTVDTRHFVPPQTPPPSVRMSPSWTAHTLPAQPTGSGTSTTFPTPPSTAGYLGHMAGRGAGSEGGGDSGHQTPAGEDEGYARRDHDGDAEMTDRPESGIDGVSSVDAEHRRTDHEREGAGGDITAPVPG
300
266
1
418
298
153










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRQKRKDFASSA
2) LIQLYDLKRIQ
3) TVDTRHFV
4) YLGHMA
386
176
26
75
398
186
33
80