<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13580

Description "Similar to Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme"
SequenceMKEMRERGHQNDSNMYQQYDQKLAQDLNGRNPIQSNVVSRNLWQNYSQNHHAYSQRQHMMNKQTSGAVHGKTPMLMANNDVFTIGPYRTRKDRLRISVLKKYEIIGYIAAGTYGKVYKAKSLMPTTPSSGTTTILPIENSSLSSSENSSGSRSNNKQDSNTSKLGTDKKFSRDINDDSLKSASANSITASLSANSTHIINSSRNDPNLAKNSLNSKERNDLNQRNHITDNLNNNMIGDSHNSTDHAITNLHSPSKKKNIPIYYAIKKFKTEKEGVEQLHYTGISQSACREMALCRELTNVHLTRLTEIFLERKSIYLVYEYAEHDLLQIIHYHSHPEKRMIPARMVRSIMWQILDGVSYLHQNWILHRDLKPANIMVTVDGCVKIGDLGLARKFSNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPSIDVWAVGCIFAELIGLQPIFKGEETKMDSKKTVPFQSNQLQRILEVLGTPTPKTWSNLHKYPEYEQFLKFPKFRNNLPAWYHSTSGRDKHVLDLLYKLLEYDPIKRIDAIDALDHNYFANGDYPVCENVFEGLNYKYPARRIHTNDSDIMDLGIHRSKNLNPQQQAVVNNSAANTLGGLGVNRRILAAAAAAAAAVTGNNSQGNSRNQEPTRKKRR
Length644
PositionKinase
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.08
Grand average of hydropathy-0.665
Instability index44.41
Isoelectric point9.51
Molecular weight73177.91
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13580
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.58|      44|      46|     156|     199|       1
---------------------------------------------------------------------------
   10-   36 (31.93/12.17)	....QNDSNMYQ.QYDQKLAQDLNGRNPIQSN................
  152-  198 (62.94/29.92)	RsnnKQDSNTSKLGTDKKFSRDINDDSLKSASANSITASLSANST.HI
  199-  246 (64.71/30.92)	InssRNDPNLAKNSLNSKERNDLNQRNHITDNLNNNMIGDSHNSTdHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.99|      74|      79|     273|     351|       2
---------------------------------------------------------------------------
  273-  351 (115.78/97.32)	EGVEQLHYTGISQsacREMALCRELTNVH.LTRLTEIFLERK.SIYLVYEYAEHDLLQIIHYHShPEkRMIPAR.MVRSI.MW
  355-  432 (110.21/74.90)	DGVSYLHQNWILH...RDLKPANIMVTVDgCVKIGDLGLARKfSNMLQTLYTGDKVVVTIWYRA.PE.LLLGARhYTPSIdVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.48|      10|      17|     121|     130|       3
---------------------------------------------------------------------------
  121-  130 (19.40/11.27)	SLMPTTPSSG
  141-  150 (17.08/ 9.10)	SLSSSENSSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13580 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANSTHIINSSRNDPNLAKNSLNSKERNDLNQRNHITDNLNNNMIGDSHNSTDHAITNLH
2) MKEMRERGHQNDSNMYQQYDQKLAQDLNGRN
3) PSSGTTTILPIENSSLSSSENSSGSRSNNKQDSNTSKLGTDKKFSRDINDD
4) QNYSQNHHAYSQRQHMMNKQTSGAVHGKTP
193
1
127
44
251
31
177
73










Molecular Recognition Features






MoRF SequenceStartStop




1) AAAAAAAAV
2) IPIYYAIK
3) SRNQEPTRKKRR
616
259
633
624
266
644