<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13578

Description Similar to Saccharomyces cerevisiae YOL051W GAL11 Subunit of the RNA polymerase II mediator complex
SequenceMNVGGKEGLSIQDRTRNVAELLKVLMDINEINGGTNATAEKMKVHAKNFESALFAKSSSKEEYLDSMKEKVTAMRNTRDTRKKSLASAKNVQNNNNNNNNGNDQMSQQQQMNGNNGFPNNNNNNMNYMPNTMNMNSQMFLNQQAQARQQAQQQLKDRQQHQQMQQQQQQQQQQQQHMQQQGQLGQGQQRHQLTPQQRQLINQMKVAPIPRELLQKIPNIPADVNTWQQITELAQQKRLTPHDMQIAKEVYKIHQQLLYKSKIQQVNANNVMNMQQTKQQQQQQQQMQQPQQIQQRQKDHQQQMTSNNNNNNNNNNTSANANANNTNNSNSNNANVVAGQQQQQMFRNRSGEVPNVLGQINQIFSPDEQRALLQEAMEACKTFQKTQFGANMTDANRQSFIRKYINQKALKKIQSSRMAQQAAAAATRSGQNNVNMNGNNEASNAGSNNNNNNINNNNMVVGNNSSNNVPSRGNMQQMNNLQNVPQQARNTPISQQQMQAQQQQQQQQQQQQQQAQQAQQAQQAQQAQQQQQQVPPSQGHQRTNSQRASMLQLLQPTPQDIETVRKISTDAARTPLRLNDLTNSISPQEREEIKRKLQMNQQLFAQVSNYAPQVYVFTKSEAFLKEVLQLRIFVKEILDKCSKGIYVVKLDTVDKLIMKYQKYWESMKIQILRRQQLIQQQQQLIRQKQQQQQDQQPQQQQPQSGNNIPINSIPTPVQNNANISQAQAQAQAQAQRMRPNQRAQLQNRQLQQQQQMQWQQQQQQMNGSNANTPQMNNNFVQMNGAIPNSNVMNAKINGRQPSVPIPPNAGMSSENDSMISQATGNQFTTANATPDVMKSNSRNASVPTSAKVSPSREKAANSNGANNKGNNSKKPSPSASTSSRNVKSLSNVPTPRLSNVSARGTPQLVGNESLSTSSGEMNPVFKKEEDELQSLNIKKTEIASRFKHRQEAFQASPVDLFLSTLSDTLGLKDDEYEPQIKFSQDFIDLTNRTGKKKKLTKVAQRARERDPVDVSIVDGNKLIMTSKYMSEQKEVRNYGINLGSIASIFNGLENNICEKLNDLAFIDTPSNNADCNTKKRKLDEMNLTPDSIKSNANDSPSIMSESKRIKFDSPEDTYVATDGKMKKSAAGMNFTTTASVPTTATITNDTGDDKKDINIWDWDYWANKI
Length1168
PositionTail
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.04
Grand average of hydropathy-1.111
Instability index50.58
Isoelectric point9.80
Molecular weight132075.34
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13578
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     732.03|     108|     108|     129|     236|       2
---------------------------------------------------------------------------
  129-  236 (198.82/49.53)	PNTMNM.NSQMFLN..................QQAQA.R.................................QQAQQQLKDRQQHQ...Q........MQQQQQ...Q............QQQQQQHMQQQGQLG...QGQQRH..QL..........TPQQRQLINQMKV.A.PIPRELLQKI....PNIPADVNTWQQITEL...AQQK
  240-  343 (135.88/31.66)	PHDMQI.AKEVY.............................................................KIHQQLLYKSKIQ...QvnannvmnMQQTKQ...Q............QQQQQQ.MQQPQQIQ...QRQKDHqqQM..........TSNNNNNNNNNNTsA.NANANNTNNS....NSNNANVVAGQQ........QQQ
  353-  487 (118.77/26.80)	PNVLGQ.INQIFSP..................DEQRAlL.................................QEAMEACKTFQKTQfgaN........MTDANR...QsfirkyinqkalKKIQSSRMAQQAAAAatrSGQNNV..NMngnneasnagSNNNNNNINNNNM.V..VGNN...SS....NNVPSRGN.MQQMNNLqnvPQQA
  488-  573 (94.83/20.01)	RNTP........ISqqqmqaqqqqqqqqqqqqQQA.....................................QQAQQA....QQAQ...Q........AQQQQQ...Q............VP......P.....S...QGHQR...............TNSQRASMLQ...........LLQ......PT.PQDIETVRKISTD...AART
  611-  723 (78.95/15.50)	PQVYVFtKSEAFLK..................EVLQL.RifvkeildkcskgiyvvkldtvdklimkyqkywESMKIQILRRQQ.....L........IQQQQQlirQ............KQQQQQDQQPQQQ............................QPQSGNNIPI.N.SIPTPV.QNN....ANIS...................
  724-  807 (104.79/22.83)	.................................QAQA.Q.................................AQAQAQRMRPNQRA...Q........LQNRQL...Q............QQQQMQWQQQQQQM....NGSNAN..............TPQMNNNFVQMNG.AiPNSNVMNAKIngrqPSVPIPPN...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.13|      18|      20|     837|     854|       3
---------------------------------------------------------------------------
  837-  854 (30.54/18.60)	K...SNSRNASVPTSAKVSPS
  857-  877 (24.23/12.90)	KaanSNGANNKGNNSKKPSPS
  882-  895 (16.89/ 6.27)	......SRNVKSL.SNVPTPR
  896-  906 (18.47/ 7.70)	L...SN.......VSARGTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.20|      17|      20|      89|     105|       4
---------------------------------------------------------------------------
   89-  105 (32.77/11.65)	KNVQNNN...NNNNNGNDQM
  109-  128 (29.42/ 9.69)	QQMNGNNgfpNNNNNNMNYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.61|      19|      19|     911|     929|       5
---------------------------------------------------------------------------
  911-  929 (29.72/20.43)	ESLSTSSGEMNPVFKKEED
  932-  950 (29.19/19.92)	QSLNIKKTEIASRFKHRQE
  966-  984 (30.70/21.37)	DTLGLKDDEYEPQIKFSQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.61|      15|     363|     647|     662|       6
---------------------------------------------------------------------------
  647-  662 (22.70/21.50)	VKLDTVD..KLIMKyQKY
 1011- 1027 (21.91/14.05)	VDVSIVDgnKLIMT.SKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.89|      14|      19|      11|      24|       7
---------------------------------------------------------------------------
   11-   24 (22.89/15.60)	IQDRTRNVAELLKV
   31-   44 (24.00/16.75)	INGGTNATAEKMKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.48|      14|      27|    1113|    1126|       9
---------------------------------------------------------------------------
 1113- 1126 (25.21/17.97)	PEDTYVATD.GKMKK
 1140- 1154 (20.27/12.94)	PTTATITNDtGDDKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13578 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KIQQVNANNVMNMQQTKQQQQQQQQMQQPQQIQQRQKDHQQQMTSNNNNNNNNNNTSANANANNTNNSNSNNANVVAGQQQQQMFRNRSGEVPNVLGQINQIFSPDEQRALLQEAMEACKTFQKTQFGANMTDANRQSFIRKYINQKALKKIQSSRMAQQAAAAATRSGQNNVNMNGNNEASNAGSNNNNNNINNNNMVVGNNSSNNVPSRGNMQQMNNLQNVPQQARNTPISQQQMQAQQQQQQQQQQQQQQAQQAQQAQQAQQAQQQQQQVPPSQGHQRTNSQRASMLQLLQPTPQDIETVRKISTDAARTPLRLNDLTNSISPQEREEI
2) NGGTNATAEKMKVHAKNFESALFAKSSSKEEYLDSMKEKVTAMRNTRDTRKKSLASAKNVQNNNNNNNNGNDQMSQQQQMNGNNGFPNNNNNNMNYMPNTMNMNSQMFLNQQAQARQQAQQQLKDRQQHQQMQQQQQQQQQQQQHMQQQGQLGQGQQRHQLTPQQRQLINQMKVAPIPRELLQKIPNIPADVNTWQQITELAQQKRLTPHDMQIAKEVYK
3) RQKQQQQQDQQPQQQQPQSGNNIPINSIPTPVQNNANISQAQAQAQAQAQRMRPNQRAQLQNRQLQQQQQMQWQQQQQQMNGSNANTPQMNNNFVQMNGAIPNSNVMNAKINGRQPSVPIPPNAGMSSENDSMISQATGNQFTTANATPDVMKSNSRNASVPTSAKVSPSREKAANSNGANNKGNNSKKPSPSASTSSRNVKSLSNVPTPRLSNVSARGTPQLVGNESLSTSSGEMNPVFKKEEDELQ
261
32
685
592
251
932










Molecular Recognition Features






MoRF SequenceStartStop




1) FIRKYI
2) KKDINIWDWDYWANKI
399
1153
404
1168