<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13574

Description Similar to Saccharomyces cerevisiae YCR081W SRB8 Subunit of the RNA polymerase II mediator complex
SequenceMSPSKYILSPPEDLHPYIARHSDRNEDEVHFRNERRYFTPETSESEQFDPVYPDFDRWKHRPEEDQIFMNFVSKGYYTTSKVNFESISARSSLHESLPKISEQLGVQFSKILQIREGEINKIPATVPAPNGSSNEQLFTTNKIYDLAGPGFALPTRVTLTDNRKEAWLHDLSKPYVSLHNVSKYIPHGLKRKRVIEQCYKKQIPLKRAMWLIKCCFLIEIQQSKSKHSGNFIKSHTSPTVRSPTNANNNIESTKIHILKEWTESFINILEKLIFEMNQYYNDADKLKIWKVEISYFLKLLGNCYSVSLLDKNIFHRWLVEFVSKVENFEFLPITLHILMTFWDNITNINQNANQLKCRNSSNFLLSKITDMLLHKYYVVSNAKSMINDERYIINDIKKNNKLKDSILAILTTMIIKLFREQSLEVFLFPPSSWELYKPCLYEIVNKSQFIENADEIRKILELISYRNETLKNTTLITEEKVSSNDENFSNHHDHYFQWSQIQHDIKVIRISHIDTKFTTLLDDNTTEFDWTQYIERDPLNKSQIIQLVLWSIHPSRLSHYESNQLVAKLLLLQINSFDGFPEYEIEDTLWSLIFQIAKLDSQNLGNMIHLESLYLLLNILITYGIIKVSTYVRKLISSGIMYLQDSNDKFFHVVLLINLKISPLMKTQYNMVLRNVMEFDPYYFENYSFDQLAIKIDNIKESISGNLFDDGQSINTVNFDEINLPLGGKIMLAEWYLNHICSNTSLQPINRETLFNNFKFFCLNLKVSHHFYKWCEFIVYHQLLNDIETMALLIDILVSFQKLFSQYINDHVLFMKTFLFIYTKILRETDSVNFQIVSFMSFWKFFMKTFPMALTIDTDLRNDLSAIYEEDKTKRLALEQSKDLVQQLFDALSQNKSSITNLNFAELFQNNTKSLLSYKVQRSLEDFKRAKSVLTLLKSSSLHDYNKFMSIFLKRKNYSDTDLICLISNKLLSLEQIKTTLGGTWIMKLLVYLEEKAEELFTEEHTHFINTIYYEHCMIDYVRANFKTVLTLCDLKDNGQYKLFTRMLTKYGPSTKFAEISADVIIRLLNDHSEETNHILGDLLQYKGAIKENTPVNGDNELNETESEDDTSMSTETDYELFGLLDFTNLWIFQAYTLYNIDQIKVQDNYGDKLAKFIFDIIEFTQNDTICSKIFDRVSDIKVTAEIIEIFEKSLFDQILMNVEIPRNYLVIVIESIIALSKKNTEVTSTTLEMSDDSIKLLVSIISFFNNMDEFALGERESVMDVVMKIFTIHQAYILKYIVEHLQDKSTAGEMKTLISNMLCLFQKLSFSLRLKLILYEILSSLKSYSIYIATSDGEHDAVENFDSITPLSSGNSSGNLYSSCKSHTFDVPKELLKLPPLQVSSFTTKPTESKTNVTTPIGITPMNAERESSKGDIFNEQEKERWFIYDKKTRTYISKLKTQAYYNINSYQTDQDPIKSINNACYNLSLFDASFENKNPA
Length1482
PositionKinase
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.12
Grand average of hydropathy-0.269
Instability index40.69
Isoelectric point5.82
Molecular weight173098.08
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13574
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.50|      26|      39|     779|     804|       1
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  779-  804 (44.23/30.88)	VYHQLLNDIETMALLIDILVSFQKLF
  821-  846 (45.27/31.80)	IYTKILRETDSVNFQIVSFMSFWKFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     396.43|     120|     152|     428|     579|       2
---------------------------------------------------------------------------
  428-  552 (199.75/172.05)	FP.....PSSWELykpcLYEIVN.KSQFIENA...DEIRKILE.LISYRNETLKNTTLITEEKVSSNDENFSNHHDHYFQWSQIQHDIKVI..RISH.IDTKFTTLL...D..DNTTEFDwTQYIERDPLNKSQI.IQLVLWSI
  580-  703 (153.61/83.96)	FPeyeieDTLWSL....IFQIAKlDSQNLGNMihlESLYLLLNiLITY..GIIKVSTYV.RKLISSGIMYLQDSNDKFF......HVVLLInlKISPlMKTQYNMVL......RNVMEFD.PYYFENYSFDQLAIkIDNIKESI
  986- 1038 (43.07/11.69)	........................................IMK.LLVYLEE..KAEELFTEE............HTHFINTIYYEHCM......IDY.VRANFKTVLtlcDlkDN.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.03|      55|      56|    1132|    1187|       3
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 1132- 1180 (70.59/45.38)	...............................IF...QAYTL.YN..IDQIKVQDNYGDkLAKFIFDIIEFTQNDT.ICSKIFDRVSD
 1181- 1237 (63.82/36.57)	IKVTAEI......................ieIF...EK.SL.FDqiLMNVEIPRNY...LVIVIESIIALSKKNTeVTSTTLEMSDD
 1239- 1310 (41.62/21.22)	IKLLVSIisffnnmdefalgeresvmdvvmkIFtihQAYILkYI..VEHLQDKSTAGE.MKTLI........SNM.LC..LFQKLS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.21|      23|     152|     745|     767|       4
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  745-  767 (41.19/23.09)	SLQPINRETLFNNFKFFCLNLKV
  898-  920 (37.02/20.01)	SITNLNFAELFQNNTKSLLSYKV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13574 with Med12 domain of Kingdom Fungi
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