<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13573

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPTPIHYRLEDVFSSFYKINTIQKINYEQYIPKNQDERWSIQMELQLRKQDPKTLVALLSKELWRFSINDDTIPPLPLGDNNENSITTVDSNISENDEKSIITPEKTGEFTADYSKPNLPPYYALFLKALRKSIYINLALNSNNTLVQFGNACIPLNNENNDKNFLLQIEPHLFSNSDLALSICVKNLEFSQLKEESLNSSYLRSHALYMAPSGIRAYIKTTTKQKYLVSPPNNADILLDTLFTSHGINLKGKKNMKWISLIPHLGHLNGQTPSVGSYMIPPSETRSITWPLDLCLVQSSFDNVSGKMDAVSSDDFQNAIDMIDDFIQIKQTSAYRTPGSSGAMGTNPMSTGGPYTEQLQPINKKSVSSVNGNLGLSPLGGTQSTLRNTGVLDAGNNLLSNSRGISPQYSTIERLAPNPADAFTGEFSTTPINNENNNNQLFNDRKHDLRMNPLKMDTDKPMTIMDDVLDDNNGDNKELFGDDDEDMIDPKDKIIGSVTQDKNLPSNPISDDDEDLFGETSEEDSKPLVSKLTSDEITEDMFGMSDDEEGNNRSSTKNTGKSKDISSDSFPEINEAFETPKKQNLKRKYLDIPIDEMTLSNSPLYMDPGAPLPVETPRERRKSVFAPLTFNPKIENNVDNKYKNGGKFSFSPSQKEEALKFDVSNGEISSSEEEDSDSSLDSFDYPNIKNDLRSLDGNINDQPYSQLTTTQDNLPTGLLSGVFNGSSELYNNREGSNSIWRLPPSEIPQTDSPLKSIEASIPSPLEGSNQSDNFGKVLNVGNFKENESSASRNVSDSSKPFNSSTSDSGNDSSTSESFTTIKQHTSSNIPFLLRHMPLSSIPDVFLYKNPTVTININDPDILNQLCEQIVFDYSLLKNFGLPNHEYQGVNIEPNGLVSKTLSSLFNNFEQIAGNTLINKIFPIKEPFVFVKKQDELIKVRSCVQEYVKFLNFKAPFGIKNFKFLLLTNSFKNDCLSFVSTLSQTYISQEFGFCELLKLSDEDANGLINVKDYEKTKLLLLAAQIVSYCSTNKNSGNDANLMIILPLESADIYEFVLKTQIFQLIRCEVRSKIPNLDLYFKLIPMEMIKNPLTSVDSYYNLCASIYNILPSKKVKYTTIAHKLPGTVTFRTMKAPHGSSVIHYDVYIHLAYSRSVDKQWIFAALSDSDGNENMIKSWFVGDSRIAFDNACNEIWSMALSLASLQFGKICLILTRLDGILPDDELMNWRRLSGRNVHLAVVCVDDSEKISFFDEDKLYPNFKPIFKNNDLSGRINPQNINDYEIRNLDEDIHGVIFEHPFPLANSQHRCAIKSGALVKFKRNSGNSTWKKFEVNLLNCPHSDSTKLLETILEEFRNLAALNLWFGVSNGEKSHIPWHVLAVKKMMNVMVHTRIEIENGNK
Length1399
PositionKinase
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.09
Grand average of hydropathy-0.481
Instability index41.95
Isoelectric point5.09
Molecular weight157248.05
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13573
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     887.03|     277|     295|     348|     639|       1
---------------------------------------------------------------------------
    3-  311 (223.88/106.35)	..........................................................................PT.PihyrlEDVFSSFYKINTIQKINYEQYIpkNQDERWS...IQME.LQL.RKQDPKTLV.ALL......SKELwrFSIND.DTIPPlplGDNNENSIT...TVDSN.ISENDEksiitpEKTGEF....TADYSKPnlppyyalflkalrksiyINLALNSNN.TLVQFGnacIPLNNENNDKNFLLQIEPHLFSNSDlalSICVKNLEFSQLKEESLnssylrshalymapsgirayiktttKQKYLVSPPNNADILLDTLFTSHGINLKGKKnmkwisliphlghlngqtpsvgsymipPSETR.SITWPLDLClvqssfdnvsGKMDA
  348-  637 (438.97/253.50)	NPMSTGGPYT...EQLQPINKKSVSsvNGNLGLSPLGGTQSTLRNTGVLDAGNNLLSNSRGISPQ.YSTIERLAPN.P.....ADAFTGEFSTTPINNENNNNQL..FNDRKHD...LRMNPLKM.DTDKPMTIMdDVLddnngdNKEL..FGDDDeDMIDP...KDKIIGSVTqDKNLPSNPISDDDE......DLFGET....SEEDSKP..................LVSKLTSDEiTEDMFG...MSDDEEGNNRSSTKNTGKSKDISSD...SFPEINEAFETPKKQNL.........................KRKYLDIPIDEMTLSNSPLYMDPGAPLPVET...........................PRERRkSVFAPLTFN..........PKIEN
  641-  831 (224.18/108.82)	NKYKNGGKFSfspSQKEEALKFDVS..NGEISSSEEEDSDSSLDSFDYPNIKNDLRSLDGNINDQpYSQLTTTQDNlP.....TGLLSGVF........NGSSEL..YNNREGSnsiWRLPPSEIpQTDSPL......................................KSI..EASIPS.PLEGSNQ.....sDNFGKVlnvgNFKENES..................SASRNVSD..SSKPFN...SSTSDSGNDSSTSESFTTIKQHTSS...NIP...............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.75|      30|      32|     974|    1005|       2
---------------------------------------------------------------------------
  976- 1005 (51.05/37.61)	LSFVSTLSQTYI....SQEFGFCELLKLSDEDAN
 1007- 1040 (45.70/25.22)	LINVKDYEKTKLlllaAQIVSYCSTNKNSGNDAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.86|      27|     295|     943|     974|       3
---------------------------------------------------------------------------
  943-  974 (44.22/31.91)	CVQEYVKFLNFKAPFGIKNFKFLlltnsFKND
 1241- 1267 (50.64/26.66)	CVDDSEKISFFDEDKLYPNFKPI.....FKNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.35|      16|      16|    1062|    1077|       4
---------------------------------------------------------------------------
 1062- 1077 (28.57/15.71)	FQLIRCE.VRSKIPNLD
 1080- 1096 (21.78/10.36)	FKLIPMEmIKNPLTSVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13573 with Med13 domain of Kingdom Fungi
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