<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13568

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSSADVDSTGVMIGRDALTNGIHDPTTNDETITNVSTVESHSVNSEFTGNNINSTDTNTTTTGSKLHTVFHDGLAPEIPHVQINQTPLSMVIRNLTIFTIKEISQYMKMNLHRTNNGGPGNNNNNNGSSVKKVNFLQLVIYLRNQFLKLYVLIKWARTIKSNNFNALIDLLNWFRTTNTSVNNCIWALKASLDSMTNAKLPNADLITALEVLSLGRPNLPSHFLNITAAGGMSNRDNDSTVPPKVVLKVLRDLNFVVSIKMALMDLPPQFNDYYVKNGRVYISVTNEFEIQLSTIDRNSPFFFVDLNFLFRTEQSLPLNKARVEKLINDLLFKNKERKPLFLLYQFLHKYILTLKLYMIHIELQALENVGKFSGGNLIHIYDSKKSIISGRYWINGKIGNKGKFTIGVDKSTEKLILRWDNDFTSEAFRTSEDKLHQNGNEINQTETNINTTEKQDDNNNNHHTIHDKFNNMPIIYNHILGNVESILDEIMFNHANVIRMKLLSTGIFQEDEGNSDVLLFQLPTTCISTAPIQMKIDLITGVFYFKNPSPLLLEYIQQINRTEKTEDLIKILQKLKLDKITHVLRNMFEKTGWICSKVVKLDTLIPTQFKTQSHGSDLLQNDLFISLPKWPVNWYLILTVISSNSSCVIEKRIGKILSSKGKWELKYLDMSSIVSSKLETMTYQKIMSLQKTILHRIVNHMLIDSLNELKIKNQICSAESIAMNLPKYVTEDDSFDKDKNSTGIIGPQEDEYTSIITMELVSFLEGSNALNSILESSMFMRIDYTNSEIRLYTRFKRDIMIKQVQCEELLIHFVKDDNLAFYMCENFKSLGQIVHYLSTFRQKLMQLVILTDVVERLHKNFASDNFKIIALKPNEISFNYLKNNAPAMLQDKKDKRDCTINIITSDMKVKNLTVNLSKTNPQHIIQPFINNGSYDYHFIFNYLQFTSSLFTTLRDIINERQENKDNSYTKVSLGLHNLSEYQLVYHNAEVGTKITLIIELKNASHNGRNNIQFYVHFSNDEHITTKSAAYPMIHRVRNEIFILDTKANSSLTDPEPKTSPTSTEGVSTALRKFPHSIRLVDGISCDSRDIETILTEIHSILKVDSNEKSK
Length1110
PositionTail
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.08
Grand average of hydropathy-0.291
Instability index35.36
Isoelectric point8.08
Molecular weight127032.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13568
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.43|      26|     132|     158|     200|       1
---------------------------------------------------------------------------
  130-  156 (40.97/19.30)	VKKVNFLQLvIYLRNQFLKLYVLIK...WA
  159-  187 (42.46/42.29)	IKSNNFNAL.IDLLNWFRTTNTSVNnciWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      11|      32|     498|     508|       3
---------------------------------------------------------------------------
  498-  508 (20.72/12.53)	IRMKL.LSTGIF
  532-  543 (16.39/ 8.46)	IQMKIdLITGVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.73|      28|      30|      27|      55|       4
---------------------------------------------------------------------------
   20-   48 (41.94/21.09)	NGIHDPtTNDETI.TNVSTVESHSVNSEFT
   50-   79 (40.79/25.36)	NNINSTdTNTTTTgSKLHTVFHDGLAPEIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.64|      18|      31|     626|     643|       5
---------------------------------------------------------------------------
  626-  643 (33.51/20.92)	SLPKWPVNWYLILTVISS
  659-  676 (31.13/18.93)	SKGKWELKYLDMSSIVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.52|      10|      31|     366|     375|       8
---------------------------------------------------------------------------
  366-  375 (18.60/12.34)	LENVGKFSGG
  398-  407 (18.91/12.68)	IGNKGKFTIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.19|      26|      55|     252|     277|       9
---------------------------------------------------------------------------
  252-  277 (47.14/29.83)	DLNFVV....SIKMALMDLPPQFNDYYVKN
  305-  334 (38.06/22.69)	DLNFLFrteqSLPLNKARVEKLINDLLFKN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13568 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IGRDALTNGIHDPTTNDETITNVSTVESHSVNSEFTGNNINSTDTNTTTTGSKL
2) KLHQNGNEINQTETNINTTEKQDDNNNNHHT
13
434
66
464










Molecular Recognition Features






MoRF SequenceStartStop




NANANA