<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13567

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMLDQHPASWSKNGIIAYSDSNSTKGNLCITFLENINGSNWRFHPPARYVIHPQLHEVPISSGSKKTNSSGSNTTVATTAATVSKSTTAGGSGSPSQHTTASNGATSNSKSSNHFFYDITSIHWNNWFSLPGDMLAVCDELGNMTMLIAGQSPEGATTFEKLTMLFQDNIYKIHNHVAPLAQQSDKNIGGTIEKKRTKKEYNTRILDFHWLSSSKSIIISQFCAFDSTSNVYRNKALQIAPSGVFYPPFMKYACMAVRRNGQLDFWYQFSNSKDHKKINLHLLPSQNQRLKELDWFQFARITPMKDDQSILVSGYSKLTKKICFYKVRVNWNTPSTNKNNTLNDPTLTVTPILEVPLSTVDSEGRVLKFYDLVVLSKTAIDKDTSAEVLIVYHICGTQKTLIKRFKLMNSYLAMDFLSVLKPGIESINGGNMQPIKSKHYTLRHGHDIFLDKRVSNITTELLDNFVTFFYDDGSVDVFNQNDWNKERERIKSQSNKSKFLNVMTSALSTGLSFQNIPLSSAIDWVRLSPTMTGIIYKLKTDHVPRFVTLTRPDLTDPSLDELDAIAFAFTFVNSTHRQLSSEDLSVACKAHIKNLSEMSEDRAKEFIMTLMSNLYPFFNVSPDAPKDIMDKMISSRPIQKIMLLQLELGTRLKDERIAQMARVILYLKNVLFAFNGVARNLQFAIEQMNNGNTNASTKMFQTLFSKQDLIYSLIPIANWFVKFVTFLIQEVLLLVNNPSESKNTLVLGVFGAKMPRQLILSVLNEIKKIMQIISKFPETTYPVLNESSTYLRMVLSDTPVNFEKFETFLIDVNNKFTAFSEQQPASEKDNILKREYSLLIQAEVPPSHSRISDFLLAYSCNAVISHIKPSDVYFTDTTGLRLTDTEFLEPNFSHLLQPISEGVVVNLLSEDQNSSKKFSQMTIDGVTYDKFSPKELQNGKMKRCSRCGAVTRAGYVIAEDKTIVPTSIHTKRWPTMYTRTCICSGMLYELQH
Length991
PositionTail
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.10
Grand average of hydropathy-0.255
Instability index44.05
Isoelectric point8.96
Molecular weight112125.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13567
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.18|      11|      28|     257|     268|       1
---------------------------------------------------------------------------
  257-  268 (19.52/14.84)	RRNGQLDfWYQF
  287-  297 (22.66/11.92)	QRLKELD.WFQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.70|      52|      90|     771|     827|       2
---------------------------------------------------------------------------
  771-  827 (81.09/58.69)	IISKF.PETTYPVlneSSTYLRmvLSDTPVNFEKFETFLIDVNNKFTA..FSEQQPASEK
  862-  916 (77.61/44.09)	VISHIkPSDVYFT...DTTGLR..LTDTEFLEPNFSHLLQPISEGVVVnlLSEDQNSSKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.15|      55|     209|     307|     384|       3
---------------------------------------------------------------------------
  324-  384 (75.08/99.69)	YKVRVNwNTPstnKNNTLNDPTLTvTP......ILEVPLSTVDSEGRVLKFYDLVVLSKTAIdKDTS
  535-  595 (90.07/53.96)	YKLKTD.HVP...RFVTLTRPDLT.DPsldeldAIAFAFTFVNSTHRQLSSEDLSVACKAHI.KNLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.21|      31|     201|       1|      48|       4
---------------------------------------------------------------------------
    4-   44 (42.37/67.97)	QHpaSWSKNGiiaySDSNSTKGNlciTFLENING...SNWrFH.P
   96-  130 (50.83/23.52)	QH..TTASNG....ATSNSKSSN...HFFYDITSihwNNW.FSlP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13567 with Med16 domain of Kingdom Fungi
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