<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13565

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTVSLQDKSVYTLILNCVDKQVPVPEFLNLYKEFYSEKFSTVLGNDDSENDINNTIEVSNNLSDDFVRLLNSKKPIVIAEYLTEILFGNYNSDLIKSFMPKLSSVHENKMLVHFFSRASLHFSTLNDKLIIDQLNKDLPDSIIPNLFTLEVNLTDNELTVTLFKFLQSIVNLATSPIILSTQYSDGSQDLLRKLSKVNKLLYRRISQVFDSKISFKDSKHLIKDIRQEYISSPSITSPQFISSPLSMMKTPMSTSGPSAAKYKDLKLLRYYKNIWLNNKIIKWEPINSDFLARYASISNSIFQENAPSPQITDALLTDLIETSFTCFAQFVSNKQYHQTNANLNLLERQWIIFISKHLPILVLKHSSSNPQVVTNALEKIDTKVIKAIKAYYSEKDDMKNRNEDLFEDYPTASLDIRHDFIKSLIMLGLQPPQFINDFLRDDQILDPKSLPTTDDLFIQTQQGTQEIVSNIPTFITDSLNSLELQTILNHNNEPNNGIHQIFLNFESISPTKQKEFSESILITLSEAIDSCNFTIITKLCALLSFNFSHSLTSILSFCTPREFVKIVMKFVDQQWSSAIVTKKEESDDSDEVINMSLSFSWALLLLINLNQIYDISLVNNSLNDGNTNLENSFSITFISRLSDIPDEFIIEGGNPKDTESQLKSHKLIQAWLSDLFVNGSISDNLMQNTDAKQLASTVPFIFKQVLYALEINAVADFDSIIGGVEYFLQPFMLSGLIKISFWLEDYLLHLKYADKQDDLINKVFKILNTIFNPNTLNEDSQTFHKAVLRINAARLLKIFRQFKKEPQANYGVYSSDSQEHSVLDTLIDKMVSVLGFSPTYYVDPRLLSSDSGYSQQKPLGYDRFMIFNENPVNKIMANQINSFWNLHSSTYYNLDYLKEVINFVTPIRFLTDVIQTLDYKLNTYGVPAIRNKITSIESEHVFDYLFYFLVLFDCETQIDAARMIQLFEDDSDYNAVGNNELPQASLHAEENNSTKNPVKTEDESHTKAEDIQDDDIDMLFGENETSTHITEEEVRIIDDVFTPKKFDDARALKRNSFGIILHDLKSLHNISYKNGNTSKDEYDRISKYHDKYLHMLKACVF
Length1101
PositionTail
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.10
Grand average of hydropathy-0.239
Instability index39.13
Isoelectric point5.05
Molecular weight126334.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13565
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.86|      36|     135|     312|     352|       1
---------------------------------------------------------------------------
  312-  352 (51.06/43.19)	TDALltdLIETSfTCFAQFVSNKQYHQTNaNLNLLERQWII
  453-  488 (61.80/34.84)	TDDL...FIQTQ.QGTQEIVSNIPTFITD.SLNSLELQTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.58|      41|      82|      36|      85|       3
---------------------------------------------------------------------------
   36-   77 (65.47/42.97)	SEKFSTV...LGNDDSENDINNTIeVSN......NLSDD..FVRLLNSKKPIV
  119-  170 (54.11/20.71)	SLHFSTLndkLIIDQLNKDLPDSI.IPNlftlevNLTDNelTVTLFKFLQSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     229.95|      85|     380|     489|     590|       4
---------------------------------------------------------------------------
  491-  513 (13.32/13.08)	.....................................................................NNEPNNGIHQIFLNFESISPTKQ
  524-  590 (83.52/56.75)	LSEAIDSCNFtiitKLCALLSFNFSHSLTSILS.FCTPREFVKIVMKFVDQQWSSAIVTKKEEsDDSD........................
  910-  996 (133.11/75.46)	LTDVIQTLDY....KLNTYGVPAIRNKITSIESeHVFDYLFYFLVLFDCETQIDAARMIQLFE.DDSDyNAVGNNELPQASLHAEENNSTKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.66|      26|     190|     184|     217|       8
---------------------------------------------------------------------------
  184-  209 (42.88/20.63)	SDGSQDLLRKLSKV.....NKLLYRRISQVF
  753-  783 (38.79/16.65)	ADKQDDLINKVFKIlntifNPNTLNEDSQTF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13565 with Med5 domain of Kingdom Fungi
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