<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13563

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMNTPLDELQWKSPEWIQAFGLRTENVLDYFSESPFFDKTSNNHVIKMQRQFSQMPGEAPPQTNGKQENENGSQENNGNNSQFNSSLLPQHDFSQAQNEFSHVEPSRRDVLTKYPMYAALERELSKLKGVEYVLACVREPDFWIIKKQNRLSSNQTDVLQDYYVIGANVYQAPTMFKVIQNRLMSTNYHLSQTIKNLHKLTQFQPSHGMQFKSTASLSSQTVMPNGSTVTSVPATAATTTTTGTFSTATTMNTAAQTANSAQYDNSRSRDMITKDMMDKLMITSIKSKPEYIQ
Length292
PositionHead
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.09
Grand average of hydropathy-0.704
Instability index41.11
Isoelectric point7.02
Molecular weight33100.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13563
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.84|      24|      30|     173|     200|       1
---------------------------------------------------------------------------
  141-  170 (33.31/19.84)	FWIIkkQNRLSSNQTDVLQDYyvigANVYQ
  175-  198 (42.52/26.70)	FKVI..QNRLMSTNYHLSQTI....KNLHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.82|      21|     158|      94|     115|       2
---------------------------------------------------------------------------
   94-  115 (34.51/31.61)	QAQNEfSHVEPSR.RDVLTKYPM
  255-  276 (34.31/25.07)	QTANS.AQYDNSRsRDMITKDMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.53|      19|      26|     204|     222|       4
---------------------------------------------------------------------------
  204-  222 (33.06/23.40)	PSHGMQFKSTASLSSQTVM
  232-  250 (31.47/21.91)	PATAATTTTTGTFSTATTM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13563 with Med6 domain of Kingdom Fungi
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