<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13560

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVADKYTDTLNEMITLLKNYKPGTVTLDNITKLCQTLGLESFIDDVDNEVARLSTASKIIVIDIDFIKSEGKVKDVKLVLASNFDNFNYFENKNSVESDLQTQDKENNILLKSLIDYPNLNEFHENLEFLYLLDSYSQLDVESNNSLHGSSSLHSNTNNHSDSNNNLVTGNLSNGLNNSPAGSNNNNNNNNNNTNNNTNNNSNNNSNNNNNVNGNNNNNTNVSNNNNNNSSSSNGNTQLEKNKLDLFRYYTELSQYIQDYLKDHTMKWNVATNLDSKFGIYIMTADAEPNVVAKITFKKSSDPQHRLYEYIYSKDTKEWINESAESYTMGVSLVMEIISGSTWFPKTFISKDVIFDNNGQTTKFKPTSINDSNDKYSNSLRSFQDPSKLLKLLTNLEDGSHPSNGNELYYHEKIQLINDFTSPLIKVPFFDISNDNIDLIDEVLTWTLWSKKVLENIVELMIIQKNDTHLYNDNHKNNSVIPNVHSDMDNNSNTTIGFNSIDHYRHNSVAGVSMTPTTTIRRRRSSNKGKRPSITEATMFKDEGLQQFNLHDVMSEQYPVITEEDNDDNMTQGPNNESITSNNNTDNNTDNNDHAVDSTKDALAMEDDSRMDIDTMELGNDIEDTREMKEEDDASEQEPIPLIISEDYITLGDIASCNLYEPVSQWETFITSFRQTI
Length677
PositionMiddle
OrganismKazachstania saulgeensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kazachstania.
Aromaticity0.08
Grand average of hydropathy-0.812
Instability index30.05
Isoelectric point4.54
Molecular weight76839.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.94|      15|      16|     187|     201|       1
---------------------------------------------------------------------------
  187-  201 (31.41/ 8.67)	NNNNNNNTNNNTNNN
  215-  229 (28.53/ 7.24)	NNNNNTNVSNNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.30|      16|      16|     561|     576|       3
---------------------------------------------------------------------------
  485-  500 (25.53/ 9.14)	HSDMDNNSNTTIGFNS
  561-  576 (30.77/12.51)	ITEEDNDDNMTQGPNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     248.90|      74|     211|     371|     446|       5
---------------------------------------------------------------------------
  230-  263 (23.16/ 6.54)	....................................SSSSNGNTQLEKNKLDLF..RYYTelSQYIQDYLKD...............
  371-  446 (124.09/74.14)	DSNDKYSNSLR...SFQDPSKL....LKLLTNLEDGSHPSNGNELYYHEKIQLI..NDFT..SPLIKVPFFDISNDNidLIDEVLTW
  590-  666 (101.65/55.18)	DNNDHAVDSTKdalAMEDDSRMdidtMELGNDIEDTREMKEEDDASEQEPIPLIisEDY........ITLGDIASCN..LYEPVSQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.67|      18|      18|     105|     122|       6
---------------------------------------------------------------------------
  110-  128 (24.54/12.32)	LLKSLIDYPNLNEfHENLE
  129-  146 (25.12/12.80)	FLYLLDSYSQLDV.ESNNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13560 with Med1 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSVAGVSMTPTTTIRRRRSSNKGKRPSITEATMFKDEGLQQFNLHDVMSEQYPVITEEDNDDNMTQGPNNESITSNNNTDNNTDNNDHAVDSTKDALAMEDDSRMDIDTMELGNDIEDTREMKEEDDASEQEPIPLIISE
2) VESNNSLHGSSSLHSNTNNHSDSNNNLVTGNLSNGLNNSPAGSNNNNNNNNNNTNNNTNNNSNNNSNNNNNVNGNNNNNTNVSNNNNNNSSSSNGNTQLEK
507
141
646
241










Molecular Recognition Features






MoRF SequenceStartStop




1) EPIPLII
638
644