<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13557

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMCSCPDSVLFLFRDYPGDPTLQVYLKQAIHDGLISLPKFVSTFLSAAKSTNLHHAATLDMLCRVALDAHYASGMPPLGSIVPYGEQIHDLLATVFNSLALLRTAHALPISHFHQLTTSASELLILLLPFATDVSQMPPQLVRPCYEEVNAMLQVLRLAPAVRQDLDSFAFSLSLLLPDTQVAREAQMMHTVLSIGRGDLTGPGSDTDLVTCSLILNGLVRPCSSFAVIHGRACEFGAGDGDHIVALLVGLYRWSAWKPVVFYTQLIVSSLTCLAQSVDAGPNSTRAALIWRAFVTGRLPLLLHRFQTAVQGDSAPDAEWHGALQNAVSLVLRRSDLMQRCDNMSLQMNSDILGEKTSPPVAVEILHQLVSVGLMEISTGATLYPALFSDFHPRLPMEAQEAGMDLVPYIESKLVAESNIDDAIAFVDRCCRDPCSHAAFAKVVEKRFTSPSHSVDLESLSHTCRILCRYNLALDIVSLHVKAQVLVAYALAFIEDYDCETVGDPRTAVTHVGDVVLFVQEAIVRCNVSYPTLRLGERQLSLDLIRSASTARPPLEFKGDDKQAYGAWFKALFDSSSEGIEDTILRNTRPKTLLRIAATLFAQAIIFCAERKIDRSILNNGIQFFMDPLLNWTSVGVAKSLMTEIRRRGYRAPLHLDVLQTLLLSSSCPPTVLRLSASSVLRLFPAVPKHELTRIAPFDPALIRRAALNALGAPTEEPPRSLGQNTVWTDHSSQAIRNAFADAQAPALDVDRCLLFNSPMDFLMMLWNEISVTATRGNIETPKRIATYVLTMPRRAQSPPLLPIFLHEHVPGLVAAADGFSLSEQATTGELLIAVISSALTAALHLEYALHSVCGEQQMVLGQSAAAMARRLGNDLRRKGNGATAAMIVKRLTTSQPFAGNFPTFMADL
Length908
PositionTail
OrganismPostia placenta MAD-698-R-SB12
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Dacryobolaceae> Postia.
Aromaticity0.07
Grand average of hydropathy0.181
Instability index46.36
Isoelectric point6.20
Molecular weight99269.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.69|      75|      89|     574|     662|       1
---------------------------------------------------------------------------
  574-  662 (101.52/98.00)	SSSegIEDTILR...........NTRPKTLLRIAAtlFAQAIIfcaeRkidRSILNN.GIQFFMDP.LLNWTSVGVAKSlmTEIRRRGY...RAPlHLDVLQTLL
  664-  754 (114.17/69.09)	SSS..CPPTVLRlsassvlrlfpAVPKHELTRIAP..FDPALI....R...RAALNAlGAPTEEPPrSLGQNTVWTDHS..SQAIRNAFadaQAP.ALDVDRCLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.89|      14|      75|     131|     144|       2
---------------------------------------------------------------------------
  131-  144 (29.39/19.02)	TDV...SQMPPQLVRPC
  206-  222 (21.50/11.88)	TDLvtcSLILNGLVRPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.14|      45|     324|      36|      85|       3
---------------------------------------------------------------------------
   36-   85 (69.58/62.22)	LPKFVS.TFLSAAKSTNLHHAATLDMLCRVALDAHYAsGMpplgSIVPYGE
  365-  410 (76.56/51.54)	LHQLVSvGLMEISTGATLYPALFSDFHPRLPMEAQEA.GM....DLVPYIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.47|      15|      70|     413|     433|       5
---------------------------------------------------------------------------
  413-  427 (24.48/18.77)	LVAESNIDDAIAFVD
  505-  519 (23.00/16.33)	RTAVTHVGDVVLFVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13557 with Med5 domain of Kingdom Fungi
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