<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13547

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAARLHAVPQDNTGSSLLAQFPPTVTLDSPVLASSITLPDQPVVAYYVFSGSPSTNAADHLNLIELARRKVLAQNVNRGILDSLLPSVHITKDASKLYVFGLASQDVPSPTSAALAALQFEGLSLSDNSTFTTNSIYPCSAACSIQTAPCPECLKPFPKTARSASSAAHLLPRKHLRMPFHHFLSAVRDRLIDDITETSKLNPNSRQAIRLKDGFILGPAAASSEWSAGWEHHARSRPLVFTHLQVHLSQTPFSARLLIHPVLRPTFYFPLCATLPVPSGTPVVLLPYGIPAYYLNTYTGPASALTAPFNDALVGLGAGEWKGAHTKRHVQSDASTSSTTSCDRKDPSYIIAWLAVQNKQGEDKGMPIIWPARLCLSYHPNSPSPHARTPLAYNPELPAQLQASPPPPPPTIPQKRDPLSTPISRRPRTVTSSPTTESLRAFRTLTLTANPSPRDVNKVASEVSGYVDSVAKERERERERLKREREGTTTRGRATSTSGPTSTSTPSAVVDQPTPGSSSVTAPPPEAMVDIAHGTPAAEDILMDEDLPSSQDSTDSLFSPPAGENTPPPDDVMHSSSDSEVKAERMDVDTMPIPIEPAPHTDVLSNFDPFNGLDASWNQPSNTFLDMGYDMGFNMNMDSLSESRMGRIGDGDFDMDEGFGDFTDEDFSFFDAPTTQTRSVPIPVPPIRLDNTIHVNEGLTPTAGAASLGYSPHPIGDDLSGPGPPVAAMSLTSSWASNLTEALTPHLGDVVPPAPELLPPSPSKTPSSYSAPATPAVQLSDGFGADDTSIPSGPRIFDPIPFAPSHRIADGKYAVGKFALASPNNMEDTMETKLFPSSAPSASTGWKWKYGLATDPRIGVMRRLVGMKRKVLGQGKREPPMSPSWVREHEDWESSTPSPWVQDSKSDGESEDDEPWVDDDDAATISRPSTPPPSYLPLGPTLLQTQFHHSRLLPLSSPLRPPGAVVSSTPCSAHPTSVPTPVSPAAILGAASEKSKSLEAAAQLLAAEIVENPVWADAWRANAAVSMAASSLPVDIWHVDVNRVATLLDNVGPTLSTGTLRAVYSPVCKSDAIVQVMPTALRFWEKLGLGPKAGLKNVTAFVFYEAGGPERESQIAAWIDQVSATYSARNYGGHAVGVSTSCSRPGLVPIRLDQVKKTLGTLQPSPQDHLVFYIITPSSTSAPASSTLRPLFSAIKRALKAYPDSGILFHLVPEAHVNGGLDDPNVVHGGLEILVASVYDRILQPVERAMSRRLFDLTPRTRACFHAPAFALASGFSAMTRHSGPRVSYTLESHPSSLDVVDRHTLLHVGYRISSCRQWLLASCTDERGDEYDWGAWLLPAESVESFIVSQIWTFTQAFAGRANVEWRVGIAKVGAMGENELEAWVIHLQDVIAAAAAAPPMHISLLVVEYENTWTLVPPSGTRTIFGLPVSSRPTPRTPSGSVLGDMTYKTYAAFPALDLTYVPALNSASAVTSTSYPSDKPYIPDCEEDELPAHQYSHPRARRMSTLIHVPTSNDHTAISMVHVYQLHSVISPHSSVTRSATVTTELLDQNLDAVESFDDAALHDIVHNYHALAVLARMRWRAPVAPTLPFHLGALEMMRAALVGSPSTDS
Length1613
PositionKinase
OrganismPostia placenta MAD-698-R-SB12
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Dacryobolaceae> Postia.
Aromaticity0.07
Grand average of hydropathy-0.228
Instability index53.03
Isoelectric point5.73
Molecular weight173727.71
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13547
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     520.73|     110|     115|     534|     644|       1
---------------------------------------------------------------------------
  570-  686 (169.93/58.92)	DDVMHSSSDSEVKAERMDVDTMPIPI.....EPA...PHTDVLSNFDPFnGLDASWNQPSNTFLDMGYDMG.FNM....NMDSLSESRmGRIGDGDFD..MDEGF.GDFTDEDFSFFDAPTTQtrSVPipvPP
  690-  779 (111.98/35.12)	DNTIHVNEGLTPTAGAASLGYSPHPIgddlsGPG...PPVAAMS.......LTSSW..ASNLTEALTPHL........................GDVVppAPELL.PPSPSKTPSSYSAPATP..AVQ...L.
  780-  857 (91.64/27.59)	.......SDG......FGADDTSIPS.....GP..........RIFDPI.PF.....APSHRIADGKYAVGkFALaspnNM.............EDT...METKLfPSSAPSASTGWKWKYGL..ATD...PR
  858-  962 (147.18/48.15)	IGVMRRLVG..MKRKVLGQGKREPPM.....SPSwvrEHEDWESS.TP.....SPWVQDSKSDGESEDDEP.WVD....DDDAATISRpSTPPPSYLP..LGPTL.LQTQFHHSRLL..PLSS..PLR...PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.79|      78|     711|     366|     455|       2
---------------------------------------------------------------------------
  123-  207 (108.95/39.14)	LSLS..DNST...FTTNSI.Y..PCSAACSIqTAPCPECLKPfpktARSASSAAHLLPRKHL..RMPFHHFLSAVRdrliddiTETSKLNPNSRQ
  374-  455 (126.62/68.15)	LCLSyhPNSPSphARTPLA.YNPELPAQLQA.SPPPPPPTIP....QKRDPLSTPISRRPRTVTSSPTTESLRAFR.......TLTLTANPSPRD
  500-  569 (98.22/35.65)	......PTSTS....TPSAvVDQPTPGSSSV.TAPPPEAMVD...iAHGTPAAEDILMDEDLPSSQDSTDSL..FS.......PPAGENTPPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      16|      20|    1000|    1019|       3
---------------------------------------------------------------------------
 1000- 1019 (18.75/28.23)	AAAQLLAAEIVenPVwaDAW
 1022- 1037 (29.45/20.44)	NAAVSMAASSL..PV..DIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.61|      44|    1140|     222|     350|       4
---------------------------------------------------------------------------
   21-   66 (69.04/12.72)	FPPTVTLDSPVLASSITLPdQPVVAYYV..FSGSPSTNAADhLN..LIEL
  269-  316 (72.58/29.26)	FPLCATLPVPSGTPVVLLP.YGIPAYYLntYTGPASALTAP.FNdaLVGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.80|      14|     711|     249|     266|       5
---------------------------------------------------------------------------
  249-  266 (23.32/19.44)	SQTPFSArlliHPVLRPT
  967-  980 (29.48/14.82)	SSTPCSA....HPTSVPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.13|      43|     170|    1038|    1092|       6
---------------------------------------------------------------------------
 1043- 1092 (60.15/63.88)	RVATLLDNvgPTLSTGTLRAVYSPVckSDAIVQVMPTAL..RFWEklgLGPK
 1216- 1260 (70.98/39.56)	HVNGGLDD..PNVVHGGLEILVASV..YDRILQPVERAMsrRLFD...LTPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13547 with Med13 domain of Kingdom Fungi
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