<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13539

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEEYNAKRIKLSLEPFINKAVADVTDTGHEVFKTDLSLPEQLMRNVDRVWYERGDWMNITEEGLQRQLTSSKIKDDTTTAIDTTTPSSTDESSKHQQKEQHINTGNLKNDQEALAVDLGKLRESVISKLYFAKCEIDVALDVMNILSTENKRNTNGMGVGGSGAGGILAGINGAAGGLGSILGGGLGSNDSGADGNNNMVLPPGTLHATYVSKPKPTEKAQLEHAQLTLGLKRTQQKTAAAYLKKSAASLKTMVEEEQEFWDQAVCVRSNHWLMQASGNTSGLWISYGFKDVGSDFPEACHGEMLRPDQNDETDTKNQVRLSLPHNIPKLVRVTVKRNRMEQHGGETGRIFDLEQGEEKIETAAQGIYPSIHNSQDNSIQRRLIDAQSTVYDAELFSRILSEAQVIPSNIQCEEDYVIVTLGGEMDIVIQKMQYNHQQQWQQTHDACPSISSQQMVGRTIETALRLLLVQRHRFNLWKSRTRLMAGQRKIQLLLDAIEDTTSSTGSGAKSTGSSSFPGAGSNLNSSISGASGVGGSHTPKLGHRTASNISTSGGTSSSSLSRKTTGSGSYQLHTSREPTSNVPILAPVISMTRFWILFDGIRDVVLNTVNPLCGETGLGLSVHFKPQHEFKSGHQAYCDAYPSFGELSTSLAINMYKGSSLQFALNQTGTITAISPGNIVTLSNVTEFEAFLLREIKLICLHLVCDIANDLIRRSPAYKKAKGNDRDGYIWQVEEVEEILYGAVQQSGNWKNIQIQLNRTTINHNSPAYVLQIQEEVLPPIVATVTNNHVQQRPKSSPQIKRFILLSQWNDSTMDGDHCDLGFRDKVVMMVAQLLE
Length836
PositionHead
OrganismAbsidia repens
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.06
Grand average of hydropathy-0.427
Instability index44.15
Isoelectric point6.12
Molecular weight91962.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13539
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.49|      15|      17|     531|     545|       1
---------------------------------------------------------------------------
  531-  545 (27.93/16.71)	SGVGGSHTPKLGHRT
  550-  564 (24.56/13.78)	STSGGTSSSSLSRKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.77|      15|      89|     661|     676|       2
---------------------------------------------------------------------------
  661-  676 (22.36/20.10)	LQFALNQTgTITAISP
  753-  767 (28.41/19.55)	IQIQLNRT.TINHNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.16|      26|     333|     163|     193|       3
---------------------------------------------------------------------------
  163-  193 (37.49/32.55)	GAGgilAGINGAAGGLGSilGGGLGSNDSGA
  505-  530 (46.67/25.90)	GSG...AKSTGSSSFPGA..GSNLNSSISGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.26|      57|     367|       9|      65|       5
---------------------------------------------------------------------------
    9-   65 (99.11/75.49)	IKLSLEPFINKAVADVTDTGH..EVFKTDLS....LPEQLMRNVDRVWYERGDWMNITEEGLQ
  371-  433 (86.15/64.56)	IHNSQDNSIQRRLIDAQSTVYdaELFSRILSeaqvIPSNIQCEEDYVIVTLGGEMDIVIQKMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13539 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSSISGASGVGGSHTPKLGHRTASNISTSGGTSSSSLSRKTTGSGSYQLHTSR
2) QLTSSKIKDDTTTAIDTTTPSSTDESSKHQQKEQHINTGNLKN
524
67
576
109










Molecular Recognition Features






MoRF SequenceStartStop




1) IKRFILLSQ
800
808