<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13527

Description Mediator complex subunit Med5-domain-containing protein
SequenceMSVSSLEKVLRYACTNGYTCTEWADPVKHCLQLSEQDLSQDLCDLLLKHFFSASRAYSMLLGSYLTYTLTGETPPTTQTVVINKSKSLVNSKQFLSQLTRRDLHFAFSQEYNNHWAYILHLLPSLVSEVDDDLRETLSWAPILSKLLVILSQVVMVGLYPQRKSNRQLHKYGQDDDMGDSDNDDMVKQPEDDLTASQLTLEDDLTQSQQLNFSVTNNTYPFANDSQMTIDPDAPFDADATQPDPYTEQQDLKKDTNSNNYGDILPPGTANTAVNAVYNSQNDLLHRNSIQANQHQYQHPSQSSSLYPNSWGESASALLPMEKTSLEWENAISAAKIIIDLIEKKGVKRIIEKFAQERKEEGIEINSIMPLDLEDTWATCREILIPDNPNSRTTTATTVQLSSEKSTSATGAHSNMYIQKLLFLLERLADRDLERQLAIHMKYHELEDEGTARAMPRADVMGLVYHMVQISPALDDDEVVSRLIKLQAIKGSFDEAFYLEIWFAALTGLREASLSINCQNMKLSNITEKQHLDHGDQNICDRTVSTNRLLWKNLVLVKLPHIINRLHEHKEKEKLANYSLKRGKHPNASQNVEPNVIELSLMKLKTFTGLLNACSPSACCYRFYVPLSKPTTFVNRLVSSGVNDDDGDNDDDDDGDDDDDDRMMDMINNSSYGTPKVFNSSAFVKAIRTINTDDIFASIVRSCQPYNFLHNSKIDILLDKMNAHEDTDHKSIKTEHYNGEGGGDHFGSTKPMLKKHLSYASLFGDLDDTIMSTDTPDQEYDSSGKLDVVTQIDQNIEQRFKSIQSNTSQESLSELIHIGLVSLVHWRKIVDFVVKLLSEKARSGDIRGLSRLCGALSDCPPAIKLILQLHPPSALLCPLESVCNEWNPSDDLMDVDDDFSGNGDNGIDDNGDDEMNGVQSWYYKFGKIWTFVLVVANKFDIAYIINRIFKNRNGLCYQFFVTGSVIYAVDAHDEEVEDTIDCWLSAMGGDGISDDLLRTTNVQMLIRATPSIIDRLLCIYNTGKIELETLTGVLSYFRRRFLQFLLVAGVTQKLCDELLTGNPSTALTCISHLFLNQLLPDALLGLCANTIFGSLRAWAECQRQYKILGSSDITKQHTQQQQQQQQADDDQATAIENYFIFKLDLDKEHITSPETSSIAVTRRTLPEKAREMFRFIVKSGRSMYMNEVDVDAKKAWEPVLNSPRAKQVVSHYLDLTLFQAALKMTGMHWFLNMIVDEVLEAGKSGGTVRAAELGSCLLTTPLIYSGQGADTCLAMLWCLLQDVVPSFVSHCASKNTSFFQGQTLGVFVSDCLVLMYHEADDQVDKLGFQFFESLAIGRVPDGDVSSFQKVSQNSDNGSKCALWNEDVVGSPVWRGFIKGLISNPFIKEMWPNAYAS
Length1395
PositionTail
OrganismAbsidia repens
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.08
Grand average of hydropathy-0.323
Instability index38.17
Isoelectric point4.94
Molecular weight156736.07
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13527
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     542.38|     211|     449|      71|     327|       1
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   71-  245 (223.11/144.08)	................................................................................GETPPTTQ..TVVINKSKSLVN..SKQFLSQLtrrdLHFAFSQEYnnHWAYILHLLPSLVSE..VDDDLRE....................................................................................................................................................................................................................................................................................................tlsWAPiLSKLLVILSQ.VVMVGLYPQRKSNRQL........HKYGQDDDM........GDSDN..DDMVKQPEDDLTASQLtleDDLTQSQQLNFSVTNNTyPFANDSQmTIDPDAPFDADATQPDPY
  274-  327 (19.65/35.07)	NAVYNSQNDLLHRnsiQANQHQ.YQHPSQSSSLY.PNSWGESASALLPMEKTSLEW....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  623-  705 (99.27/39.05)	.......................................................................................................................................................enaisaakiiidliekkgvkriiekfaqerkeegieinsimpldledtwatcreilipdnpnsrtttattvqlssekstsatgahsnmyiqkllfllerladrdlerqlaihmkyheledegtarampradvmglvyhmvqispaldddevvsrliklqaikgsfdeafyleiwfaaltglreaslsincqnmklsnitekqhldhgdqnicdrtvstnrllwknlvlvklphiinrlhehkekeklanyslkrgkhpnasqnvepnvielslmklktftgllnacspsaccyrfYVP.LSK...............PTTFVNR.L........VSSGVNDDD........GDNDD..DDDGDDDDDD...RMM...DMINNSSYGTPKVFNSS.AFVKAIR.TINTDDIFASIVRSCQPY
  706-  918 (200.35/94.58)	NFLHNSKIDILLD...KMNAHEdTDHKSIKTEHYnGEGGGDHFGSTKPMLKKHLSYaslfgdlddtimstdtpdqeydssGKLDVVTQidQNIEQRFKSIQSntSQESLSEL....IHIGLVSLV..HWRKIVDFVVKLLSEkaRSGDIRG...........................................................................................................................................................................................................................................................................................................LSRLCGALSDcPPAIKLILQLHPPSALlcplesvcNEWNPSDDLmdvdddfsGNGDNgiDD...NGDDEMNGVQ................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.66|      29|     449|     534|     565|       2
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  534-  565 (44.70/41.76)	GDQNICDRTVSTNRLlwkNLVLVKLPHIINRL
  987- 1015 (48.97/34.87)	GGDGISDDLLRTTNV...QMLIRATPSIIDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.90|      16|     449|     492|     508|       3
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  476-  491 (24.87/18.92)	DEVVSRLIKLQAIKGS
  493-  508 (28.03/15.40)	DEAFYLEIWFAALTGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.86|      88|     720|     361|     456|       4
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  361-  456 (127.21/137.39)	GIEINSIMPlDLEdTWATC.REILIPDNPN.SRTTTATTVQLSSEKSTSATgAHSNMYIQKLLFLLERLADRDLErqlAIHMKYHELEDEgtARAMPR
 1084- 1173 (143.65/118.13)	GLCANTIFG.SLR.AWAECqRQYKILGSSDiTKQHTQQQQQQQQADDDQAT.AIENYFIFKLDLDKEHITSPETS...SIAVTRRTLPEK..AREMFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.66|      24|    1337|       3|      27|       5
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    3-   27 (40.37/34.17)	VSSLEKVLRYAcTNGYTCTEWADPV
 1343- 1366 (44.28/30.92)	VSSFQKVSQNS.DNGSKCALWNEDV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13527 with Med5 domain of Kingdom Fungi
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