<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13525

Description Mediator complex subunit Med5-domain-containing protein
SequenceMTSLVLEKVLRYAYFNGYTCTQWADPVKQCLQQTEQDSSQDLCDLLLKHVFSTPRVHNLLLESYLTYALTGESQTTKQGIVIDDSKSLVNGKLFLSRLLARDVRFANNGEYNHQWSCILNLLPSLLVDVDGDRKEHLTWAPILSQLLVLLSHIVAVGIYPQRKSTTTAQHLRYNDLDESDNDDDVDDTVNQQILTDNMTASQQQNFSLTNNTNQMALDSQMTYDPDATLDIDATQPDPFDGLDEQKITNGGGDSILGASSTSATSANGVFQTHLTEQQRDVLSTSAAAQQQTSQASSLYTNTCPTSSTLSSTRNNLEWDNAISAAMIIIDLIEKKGAKRIIEKFEQGQKGRELDDSNDQTLETIDPWATCHGILVPGDQKPSSAAPATSSSTPNAHNVYIQKLLLLVERLTDRDLERRLAVHMKYHELEDEGTARAMPSAGLMGLVYHMVQIRPVLDDEDLVNRLVKLQAIKGSFDESFYLELWFAALTGLREASFNTSCQNNMTPRNTTDTEKLDDSGSSTCNTTVATNRLLWKNLVLVKLPHLINLLQKRKEKEELANYSLKRDAHQEPSSEKAVESNAIESSLMELKTFTGLLNACSPPACCSEFYVPSSKSSNLVNQFAFGGGNGGQQQLSSAMEDDDDDSMMHMINDMSYAAPTDFNTPTFIKAIRSISTDDIFTCIIHSCQPYKFLRHSKLDMLLNKTGANGTNATTNTSNPIKSEQYDNTDDTDILTGNGLKQENGYPSSLFDDDHKMTEADDPNQHDDKGEKPDNLAQIEQNIVERMNAIQANLTRASISELIHIGLVSLICWQKIVDFILKLLQEKAQAGDVRSLSRICDALDDCPSAIDLILQLYHPSVLLSPLESICNEWNPSEDYMDMDDGASGSNENEEDDDDDMDGIQNWYFKFGKIWTFVLVVGNKFDIARNIDAVFKNKTGLCSQFFITGPVVYGAHAHDQEVEDLVGRWLSAMGGDGISDDLLRTTKLQLLLRATPTIIDRLLCIYDSGRIDMETFTGVLSYFRRRFLRFVLVNGVTDVLCDELLSRNASTALTCMSHLFLNQSLPDTLIGLCGNAILGSLRAWMECQRQYRKLLVNKNRNNISDMQQQHQIPNEDDNQANFLEQFFISKLDLDEEQHLSVPETISSGITRRTLFEKAREMFRYIVKSGRSMYMNDVDKDAKTLWEPVANSKPPKQVVTHYLDLIMFQAALKMGGAHWFIGMIVDEVLEAGKSGGAVRAAELGSCLLTTPLTCNAHGDSACLVMFRCLLQDVIPSSINYCSTRNTSFFQGQTLGVFTSDCLVLMYHKAGDLVDELGEKFFEALVIDRVRGGDVSSLQMVPQSSEDGTRFALWNEEVVGSPVWRGFVKGLMSNPFIKEMWPGAYAS
Length1382
PositionTail
OrganismAbsidia repens
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.07
Grand average of hydropathy-0.322
Instability index43.61
Isoelectric point4.79
Molecular weight154174.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP13525
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     465.85|     183|     333|     605|     820|       1
---------------------------------------------------------------------------
  159-  299 (149.24/81.17)	Y.PQRKSTTTAQHLRYNDLD..........ESDNDDDVddtvnQQILTDnMTASQQQNFSltNNTNQMALDSqMTYDPDATLDIDATQPDPFdgLDEQKItngggDSIL...GASSTSAT..SANGVFQTHLTE.QQRDVLsTSAAAQQQTSQASSLY...........................................................................
  609-  820 (278.69/237.88)	YvPSSKSSNLVNQFAFGGGNggqqqlssamEDDDDDSM.....MHMIND.MSYAAPTDFN..TPTFIKAIRS.ISTDDIFTCIIHSCQPYKF..LRHSKL.....DMLLnktGANGTNATtnTSNPIKSEQYDNtDDTDIL.TGNGLKQENGYPSSLFdddhkmteaDDPNQHDDKGEKpDNLAQ.IEQNIVERMNAIQANltRASISELIHIGLVSLICWQK...IVDFILK
 1102- 1164 (37.92/ 8.26)	.......................................................................................................................................................................DMQQQHQIPNED.DNQANfLEQFFISKLDLDEEQ..HLSVPETISSGITRRTLFEKareMFRYIVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.52|      16|     332|      52|      70|       2
---------------------------------------------------------------------------
   52-   70 (24.87/25.58)	STPRVHN.....LLLesyLTYALT
  391-  411 (23.65/14.21)	STPNAHNvyiqkLLL...LVERLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.43|      28|     195|    1028|    1055|       7
---------------------------------------------------------------------------
 1028- 1055 (49.59/36.27)	VLVNGVTD..VLCDELLSRNASTALTCMSH
 1224- 1253 (44.85/31.98)	VLEAGKSGgaVRAAELGSCLLTTPLTCNAH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13525 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASQQQNFSLTNNTNQMALDSQMTYDPDATLDIDATQPDPFDGLDEQKITNGGGDSILGASSTS
2) NKTGANGTNATTNTSNPIKSEQYDNTDDTDILTGNG
3) YPSSLFDDDHKMTEADDPNQHDDKGEKPDNLAQ
200
702
744
262
737
776










Molecular Recognition Features






MoRF SequenceStartStop




NANANA