<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13506

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNRITMTRRPPVDSEDDLNALVGLTWLKPKDLVLPFYRPALKQNNQWDFSASQHKALGPYNRSGKSALVAVTRGGTIRLVLQGADNRWYYVSAEIESILTSSDVLTHAALCGDKDNTLLLVVHTRGKQLRLFRIDLEWSPANSKQQDPLMPTIHIQHVKIEGMGSPLIVPQDINDPSGLGRGFGSQAQLSHLDLMPHGPETRNSEPTYPTIVAVFSHIPNQYDKGELHEDAFSIIARWQLCITKASLHPAFDQLASKKTQAAQIGELASDINLRRLRDVRIEKIIIDIQQLSLSTVISTAYSDGVIDFRDRTAMEVLPFDDKTKQVSSLGQIGFTMSGAEPCIHIALSPNSCAAVCSYDRIESLQLRLLHYSERTSNEPLNNLVTSAATTAFALLFCISSMSHHNSDDLLAVMQLFRNQMSNSQVNAGLSGSFEHVFLSEIYRHLNVNADHSMDPQHEKLFRQNIMQRCLSVQASLGYKGERSHRNLTAKLAWTMLNLRMTWMTFVSAFTRGSGLGGAGGGENDLGKPEVLQSLLGLVKWSIDLMNCVVAELFELQNLLRSETSTDRARLTTKVKELNNPALSLVLASTSRVFLRYNCRVLRGIHNAANNAPHSNQPARSLQAVFEQSPINVMQFEPILAEVDNGIKKAYLAAGVGETDRQVIEKEMLIAADIPEILVGIVQHLLYNTLENLHQDIDPGELYFRDHSWLGLTDDRRSDAFRKNHVIDIMRKIVLGEDIDVPSFSSFQAQTPRVTASPVRRKPLPAAASPVLQQLSSGGAVVAVGEDESRAHAYNPTYLDDPPPTAHHVPWLPTLSAGSPTLLVRDLDQYPRGHSPAIPQSAQIPALTTDYQRQALQSLDRNASSPTRPHHGRITSEPVLYEQPNQDKSADNNGLQRAATMSVHPGRPRPLHLDASNRDFSNLSHESHESSTTSRSKSSGPSKLTSFFGWKTSSPVAESSPTTVSERSHSPAPSTHSPAPFLSLSSSTRTLPPAINVSKANAPVPTRYFADTGLSLPPAVMSIQVGEMEEELREISSELAGSIRREMELEDLVERLQYEATQAPELGRRTSDYFSDSGTSSIRYPLSEVGGSKAEDLQKMKRMSEQEMARVKLDTSQKLQDERERRKALELHIQNLEEQVQQINQEHARSSGTTSRVRELEASLEDVRRRLLEELQVKENFQNLLTALRGDLAQHRNERDNLRDEVVPQLRARLDVLEAESTDFQKLTYETTRMQQELQSVKEENTTLTNARKFQQDTQHHSPRFNSIAEEGSSPAVSTSPRVGISRSNTVARGSGMGAGISKTVPISRSNSVSTRERESRDSLSDRVRDIEMQRDALHSALKSLLDRQKYQTREHEKKVRALEQDRERLLQAQSPRRMGYEMEVRGLRNEINHLRRRADEALEQKWRCEKGLGGLKKDLDRAEQETSSLRTLLHENDILVPDLPGRSPQEIQADTHATSASLERAYKELQATQASSVARLRELRGLAPSAAEDTNTAETMDLLVKSMSDAEAERDLAQRQAEAYRAQAESLQGTEAFHSGENHGLAEQLHASADRVESLAAQVRDQLEANSTLRARLAEAVGRGEREQKASATRINTLQGRLKLLEDKVMVAQQHSEDAVSAHEDEVLQMRESHNVQLQRFKSAFKPGPLSSSSPAAIPNTATYLPSPTGAAMARSPLSPLLLVVGAKSPRLDRTTSGAGMSMTEALRTEFLEKRVEELEAALREADREMEEVVQRMNAAQIEVGELQSARDEAMRQTRRLQAAITEEREKVGRLMR
Length1777
PositionTail
OrganismUmbilicaria pustulata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Lecanoromycetes> OSLEUM clade> Umbilicariomycetidae> Umbilicariales> Umbilicariaceae> Lasallia.
Aromaticity0.05
Grand average of hydropathy-0.547
Instability index53.26
Isoelectric point6.28
Molecular weight197874.14
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13506
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     290.98|      59|      62|     907|     965|       1
---------------------------------------------------------------------------
  742-  798 (56.89/29.91)	.S...FSSFQAQTPRVTASP.................vrR..........KP.LPA.AASPvlQQLSSGGAVVAV.GEDESRAHA.....YNPTYL
  805-  873 (62.97/34.07)	AH...HVPWLPT..LSAGSPTLLVR.dldqyprghspaiP..........QS.AQI.PALT..TDYQRQALQSLD.RNASSPTRP.....H.HGRI
  874-  943 (64.33/35.00)	TSepvLYEQPNQDKSADNN......glqraatmsvhpgrP..........RP.LHL.DASN..RDFSNLSHESHE.SSTTSRSKS.....SGPSKL
  944- 1005 (69.06/38.24)	TS...FFGWKTSSPVAESSPTTVSE..........rshsP..........APsTH....SP..APFLSLSSSTRTlPPAINVSKA.....NAPVPT
 1006- 1079 (37.71/16.79)	RY...FADTGLSLPPAVMS.IQVGE........meeelrEisselagsirRE.MELeDLVE..R....LQYEATQ.APELGRRTSdyfsdSGTS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     315.18|      54|      62|    1437|    1490|       2
---------------------------------------------------------------------------
 1203- 1270 (38.53/18.20)	................DEV..V....PQLRArldvleaestdfqkltyettRMQQ.............ELQS.VKEENTTLTNAR..........KF.Q.QDTQH.HS.P.R..FNSIaeE
 1271- 1320 (43.51/21.67)	GSSPA.................vstsPRV.G....................ISRS.............NTVARGSGMGAGIS.............KT.V.PISRS.NSVStR..ERES..R
 1322- 1360 (30.81/12.81)	SLS................drV....RD.......................................iEMQRD......ALHSAL..........KS.L.LDRQKyQTRE.H..EKKV..R
 1361- 1435 (31.68/13.42)	ALEQDR..........ERL.........LQA....................QSPRrmgyemevrglrnEINHLRRRADEALEQKWrcekglgglkKD.LdRAEQE.TSSL.RtlLHE....
 1437- 1484 (66.56/37.75)	................DIL..V....PDLPG....................RSPQ.............EIQADTHATSASLERAY..........KE.L.QATQA.SSVA.R..LREL..R
 1485- 1543 (48.90/25.43)	GLAPSAaedtntaetmDLL..V....KSM.......................SDA.............EAERDLAQRQAEAYRAQ..........AEsL.QGTEA.FHSG......EN..H
 1544- 1599 (55.21/29.83)	GLAEQL.......hasADR..V....ESLAA....................QVRD.............QLEANS.TLRARLAEAV..........GR.G.EREQK.ASAT.R..INTL..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.13|      19|      49|      68|      88|       3
---------------------------------------------------------------------------
   68-   88 (29.83/26.74)	LVAVTRGGTIRLVlqGADNRW
  120-  138 (35.30/24.28)	LVVHTRGKQLRLF..RIDLEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.86|      22|      48|     414|     435|       4
---------------------------------------------------------------------------
  414-  435 (39.99/24.37)	QLFR.NQMS...NSQVNAGLSGSFEH
  459-  484 (29.87/16.35)	KLFRqNIMQrclSVQASLGYKGERSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.66|      33|      43|    1103|    1137|      10
---------------------------------------------------------------------------
 1103- 1137 (45.23/36.47)	SEQEMARVKlDTSQKLQDEReRRKALELHI.QNLEE
 1149- 1182 (48.42/29.66)	SSGTTSRVR.ELEASLEDVR.RRLLEELQVkENFQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.31|      20|     105|    1625|    1644|      15
---------------------------------------------------------------------------
 1621- 1642 (27.69/16.31)	SAheDEVLQMRESHNVQLQRFK
 1731- 1748 (21.29/10.68)	....EEVVQRMNAAQIEVGELQ
 1749- 1762 (23.34/12.48)	SA........RDEAMRQTRRLQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13506 with Med16 domain of Kingdom Fungi
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