<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13503

Description Ribonucleoside-diphosphate reductase
SequenceMDSLEIDGRKERVQFDKITARVSRLCYGLDGDHVDAAAITQKVISGVYQGVTTIELDNLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQFSAVVSDLFHYVNPKNKRPAPMISQQTHETVMRHAEEFNSAIVYDRDFNYQYFGFKTLERSYLLRLDGKVAERPQHMIMRVAVGIWGDDVEKVLETYNLMSQKYFTHASPTLFNAGTPQPQLASCFLVDMKEDSIEGIYDTLKTCALISKTAGGIGLNIHRIRATGSYIAGTNGSSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFLALWTPDLFMKRVEKNGEWTLFCPNEAPGLADVYGDEFEALYEKYEKEGRGRKIIKAQKLWYSILEAQTETGNPFMLYKDACNRKSNQKNLGTIRSSNLCTEIIEYTAPDEVAVCNLASLALPTYVDASRGEYDFGKLHEVVQVLVRNLNKIIDINHYPIEEAKRSNFRHRPIALGVQGLADAFLALRLPFDSPEAKQLNIQIFETIYHGAMTASCQIAKESGRYSSYDGSPVSQGIFQYDMWGVTPTELWDWQTLKADVAKHGVKNSLLVAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQVVNPWLLKDLVDMGLWSDNMKNRIIADGGSVQNIPNIPADIKALYKTVWEISQRTIVQMAADRGAFIDQSQSLNIHLKDPTMGKITSMHFAGWKLGLKTGMYYLRTMAASAPIQFTVDQEQLKVADTNIARTGPGKKRSNTSSAYSSNAHSAVPRPMYVQKPPLTPTPSSNGVLTPIATPPSTSENKKFSPPSNKSSKVLPTFKADVDEGESPKTLATEPTTSMAEEEALPDPAINDAKKQEEDAESESTDREGDIYAEAVLQCLFPQRNLQLAHALDFFMKQAGLYDAIDDALGTNLLDAADLEALSYQQSVPDSPVVLTRAYLYVFLNSMLIGRPLFDETPVSELLLARYRNDNTSLVTDLITASFDVLANAMYRNEPNDLIFLIRSFLVNRLPIFLSVLAGALFPPMTVEYCITQALNHVDPAAFQSFTQMFNPLDSSGMLSEARQEFLFACALHKLIPEQSIERLIGDLPMQSLPEAGKYVKEDLVAQCTANPGRIEELIGELENMEGNAGEIASALVEIIQSLCASKDTMTLKCVCGALSRRTQALDVIMLFTRPFSLLQPLCQLLDNWVVEEDQGEHQPVYDEFGGVFLLVYVTRHRYDLQQHDLGVSGQVSFVLKYLHAGSSSRSLKDLPSEEFQQLGAWIRGLFETEAITNELISTCKPQEFYLLVATLFKQSLAACQAGVLSLDVLKSGFEYLLEPFLLPSLVGGLAWFTQTIWEMNGQSKELDNTLSALQALLKPNSMSGESSAIHSAVLSIIARPLEHSLVHIQRHQPRRQDIDPLLSVLRLHSHAQRSDATSPTELDLWSSTNGGGLSAAVRHTFRTLTQWGLAASLDLAPPPSYTHRQLLVVVRILGADAVLQTILDEIMNQEASTFEDVALDVAAALICAPSGAYPAIPNGMFSDAPKRQLTLRDALQLSYADAFKLSKDNSYRAALTVRLYRRVEGLLQTLANHTTNVIPVTDEMMVDLDSAAARGQISGTSAVGGPHTDINDVLAEVEQDIAVQEFLTGSNAFGEIS
Length1659
PositionTail
OrganismUmbilicaria pustulata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Lecanoromycetes> OSLEUM clade> Umbilicariomycetidae> Umbilicariales> Umbilicariaceae> Lasallia.
Aromaticity0.08
Grand average of hydropathy-0.163
Instability index43.59
Isoelectric point5.29
Molecular weight183928.08
Publications









Function






Annotated function

Provides the precursors necessary for DNA synthesis.
Catalyzes the biosynthesis of deoxyribonucleotides from the
corresponding ribonucleotides. 


ECO:0000256	RuleBase:RU003410

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	GO:0004748	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
DNA replication	GO:0006260	IEA:UniProtKB-UniPathway
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13503
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     457.33|     152|     510|     357|     519|       1
---------------------------------------------------------------------------
  357-  519 (226.41/195.13)	PGLADVYGDEFEALYEKYEKEGrgrKIIKA...QKLwYSILEAQTETGNPFMLyKDACNRKSNQKNLGT..IRSSNLctEIIEY..TAPDEVAVcnLASLALPTYVDA...SRGEYDFGKLHEVVQVLVRNLNK..IIDINHYPIEEAKRSNFRHRPIALGVqgLADAFLALRLP
  869- 1032 (230.92/158.70)	PAINDAKKQEEDAESESTDREG...DIYAEavlQCL.FPQRNLQLAHALDFFM.KQAGLYDAIDDALGTnlLDAADL..EALSYqqSVPDSPVV..LTRAYLYVFLNSmliGRPLFDETPVSELLLARYRNDNTslVTDLITASFDVLANAMYRNEPNDLIF..LIRSFLVNRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     485.49|     158|     169|    1107|    1275|       2
---------------------------------------------------------------------------
 1107- 1275 (239.07/187.18)	GDLpMQSLPEAgKYVKEDLVAQCtaNPGRIEELIGELENMEGNAGEIASALVEIIQS.LCASKDTMTLKCVCGALSRRTQALDVIMLFTRPF.SLLQPLCQLL.DNWVVEEDQGEHQPVYDEFGGVF..LLVYVTRHRYDLQQHDLGVSgqvsfVLKyLHAgSSSRSLKDLPSE
 1281- 1443 (246.42/157.92)	GAW.IRGLFET.EAITNELISTC..KPQEFYLLVATLFKQSLAACQAGVLSLDVLKSgFEYLLEPFLLPSLVGGLAWFTQTIWEMNGQSKELdNTLSALQALLkPNSMSGESSAIHSAVLSIIARPLehSLVHIQRHQPRRQDIDPLLS.....VLR.LHS.HAQRSDATSPTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.77|      66|     179|      44|     112|       3
---------------------------------------------------------------------------
   44-  112 (105.29/93.82)	ISGVYQgvtTIELDNLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQFSAVVSDLFHYVNP.KNKRP
  228-  294 (108.47/87.20)	IEGIYD...TLKTCALISKTAGGIGLNIHRIRATGSYIAGTNGSSNGIVPMLRVFNNTARYVDQgGNKRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13503 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKVADTNIARTGPGKKRSNTSSAYSSNAHSAVPRPMYVQKPPLTPTPSSNGVLTPIATPPSTSENKKFSPPSNKSSKVLPTFKADVDEGESPKTLATEPTTSMAEEEALPDPAINDAKKQEEDAESESTDRE
758
889










Molecular Recognition Features






MoRF SequenceStartStop




NANANA