<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13499

Description "Mediator complex, subunit Med12"
SequenceMTSHPAVGFRRPPLPSSSSSFPRPPSRTTWHASPQLPRPASQQVAIKLTDASTSSRELLGPAYKRQKLDDGATSAGLTSPPLADGEQTHQACQQSIVGSPASLKINPATLNPLRVQDPRYAEDRSRSSLPFPIRPGKYAPRPPKGQRVDKAATRGDVQVKPYVVSVPTSAPHYSTGRPADFFPWTGNHAEDILTEQTTKTGFYEKTPVGQNETNSAKPSISTSLKHKSGLQILSSLFVSALDRRRAHGTVTANSTFKPPPRVTLTDTKREAWLRDLADPTIPLRRLSRTIPHGIRGKVLLDHCLHKDIPTGRAVWLAKCVGANEIRAFKRKGASGAFAVGGEAKWIREWTSHVEQFVESTIDSCGTANWKDLISYALRLSSQLFSEHLMDQDHYIDWMIASLHNSDLDNVPIWLLITQIHWKEILQHRRRGRRLAEALLEQLQRVHSHDGDEFLVPVQEQLVRLLNSFMTANPACFIIPSSWLKYEPLLRSCVVGEKATLISALEQISGRNLRLIRSRDKQFHHATKDARPELIAVLDNIPAAFNLHRMSKACLQVNGSRELLITTVLEWASSLYRRGQARIYAAVRLLRKWARLGIDIGRPILAFLAASPTIMGLEKDNIYRIIAELVRSKHFSVGKYLQWLLARGSLSGRHSLSPRDSCDARLLCELPLHDLPDHVLNLRRILLTSVGYSTDDEKAAGETAKASIVEQVPGLLPLSEPSTQALLPSFDEIPLSGTARWDLGRWIRKGIASRFQSYRNGPEPDAKATHVGDSKEATITVEELTKILEFLEHLEDFSILADVLCIVTDCEDARVLNVAVDTINRHIDIFAAIGAADDLFERFCQRRDEIHAQMPVMKSLVVSLIDLGENLSSQASLVRQLRKLVLSYERKFTIAACSPVSDHMAEALQSTESNFADELEQLLARGSSMDRQILSRLFETVMSRIGLPGDESVASVNLSELLTRLRLFDTRAFDQLMHDWLDKLLQSPVRPRLLDVLPTLICSGCTTLRAVVDQASLLLGVPGQNPKAEKLATDTLELLCSPAPLDHLSMHCQSVVQTPQRAYRFRREQECIIRTHPSQLVLIVRATIIACTEGPPLTQLRARTLISSSEVGSLLKDIMVRHPESMPELYQAFTAGPLVDQVKLAIDQLLDPGSEQDILHEDVDSQIVAIMQVANDFNLPFCQLKLKFTLRRPDATRLDSGQESVVPTLMDAIRSSIDRGSTVWARVIAVLEKSHTAQLREMAEAELLCYLTARTSAISSSLKQMTTTLEGLLAIIDVTNDGSVPDAGASDLFTHVVKTLDYVLSAFSSVASEAPTLELEESASVAKQQQLDVICLKSVTHSFDSRIDIDDPSIDVILRLLVIHHCTFSHLKSYQSNIVRLLLTLGSLLVHRGLTHNATLSTHIFDVLALLADSAADDTRATCIRILADQHQTRDPRLRFLFGYSDGIGGEGLQLTSSPTSSSSPRAAATTASEWQRGAADMTMLQPFPLKQWEMMQESTPIVGENDTSLSLGLFGARRAVLQL
Length1523
PositionKinase
OrganismUmbilicaria pustulata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Lecanoromycetes> OSLEUM clade> Umbilicariomycetidae> Umbilicariales> Umbilicariaceae> Lasallia.
Aromaticity0.06
Grand average of hydropathy-0.164
Instability index50.30
Isoelectric point7.16
Molecular weight168784.22
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13499
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     437.68|     126|     231|     901|    1038|       1
---------------------------------------------------------------------------
  625-  725 (134.69/104.39)	IAELVRSKHFSVGKYLQWLLAR...GS....................LS.......GRHSLSPRDScdARLLCELPL...........HDLPDHVLN......LRRILLTSVgystddekAAGETAKASIVEQ......VPGLLPLSEP.STQAL
  729-  839 (116.06/90.19)	...........FDEIPLSGTARwdlGRWIRKGIASR.FQSY..RNGpEPdakathvGDSKEATITV..EELTKILEFLEHlEDF.SILADVL.CIVTDCEDARVLNVAVDTI........NRHIDIFAAIGAADDLF..................
  903- 1035 (186.94/188.11)	MAEALQSTESNFADELEQLLAR...GSSMDRQILSRlFETVmsRIG.LP.......GDESVASVNL..SELLTRLRLFDT.RAFdQLMHDWLDKLLQSPVRPRLLDVLPTLI........CSGCTTLRAVVDQASLLlgVPGQNPKAEKlATDTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.02|      44|     399|      86|     151|       3
---------------------------------------------------------------------------
   31-   85 (60.58/32.37)	HASPQ..LPRPASqqvaIKLTDASTSSRELLGPAYKrqklDDGATSaglTSP.PLADG
   90-  136 (70.43/63.02)	QACQQsiVGSPAS....LKINPATLNPLRVQDPRYA....EDRSRS...SLPfPIRPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.13|      31|     171|     143|     191|       4
---------------------------------------------------------------------------
  143-  174 (49.04/50.50)	PKGQRVDKAATrGDVQVKPYVVSVPTSAPHYS
  198-  228 (52.08/19.12)	TKTGFYEKTPV.GQNETNSAKPSISTSLKHKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13499 with Med12 domain of Kingdom Fungi
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