<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13497

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPHNALTNVHKIDGVQSIYWETFSADTTTATTSTGGPCSPIQSPQADTFGKATDVLYKVQTDLRRSGRHVFYDKDSSKLWVVRLFATEPMNGAALDEDSKIADTISCHGLKKTDSGSLRAVDLPLGLPAALEAKTDVATAHTTTIPPAHKQIVQLKASYDRSGASDGAVANVQAAVIDSSDRTAQSPQDVYSKLVSATLLSITYLLAERGAYIPLGSHLMIEVPTASPAMNDMVLENEPTGLKATELQVHWATSGSLTISASPSSPVGFRQVSTAIADIDHTSDAFYGWEIRLAPSSFPAKLRAIESRSGSGTPAYDEAMPDFDRVCMIDQRQLHRRTWKSRVRGFLAARGMSISDQERWIEAELTVPHTLINACDTAVQPGTVKTETILWPAALCFFLDQPGVQSNTEHAAWLFRPMEDFFHDPLLEAETWFNARAEREAAIESKRQEKELLAASKQAASVDDGEEDTSEIYSRTNQYIDAQAINGVYPTPPDGFQPQAIGATTTNDPRTSPAGHGASIIAVDTPQGTQVAATPASMPRGFGLGSGSYVNNDDDDLFGDMDTETFATNGLTEADFSFFDEPDVVTKEIPHDKHDSYEPLVTDVHDITTTVEDMAIGRMAPSLGSSNNDEMNKSAAYKQAPFFNVQSRETKNGQAEVADILSPPQSPENSRKIVQPGFRTSSAMGKDSTAQIGVVKAPSAVGGRHHQHQRSLFDPVILSHSGQIYDDKYADHGKYDFKASASPLDRDARKVTSLQGKSIPRLGLHPRRKTEASIQHGPCLATSDNTLAQTPRHPESSGENYSTYSDTAEGENSYLDLHKDLSIKSPGTGETSSHGVLRSKKRKRGMDYVDELVMSPSLRTGYASDESDDALSYPEPSILVSNSIQDFAIPIGELSMAPVKRLKDSSTNIETLNDNDYVQLAQILADQLAFRDNAWPPTVASSDSYGILSTGYAMPDEEPFAGIISTLFRNSEQCDLKTYADIGLQTLEEPAVVKTVVRSDQRRPTLPSHGSLRANVQHGISKMQVPYVRVQRTAKSMEVLSSAYPFWETLGLGPCYGPKEINAYCIYLSNDGIQRSVDTFLNMLGNIYDGCKLGTHKRGMNIDGPGDGLVPVETKFEGQDGATRPVPEDFIEAVESACEELGKSLSRNPTQGQNIVVYMVDTFGESRALPELCAAFLGMFQAYVSAPQVQQLENPSDLVLQIVPEGFIASKETIAMPLPAEYRRLAFEVYDRCVPVASERHVEMLNSAPAVQLAETLPRTIEFSLTAEPASSLLRTDRCLHVGYSYKSGNGWLSAAWTDSLGAQQWSASYGLCRGTNDIRRSFSEIAKEIWETTVDIIRARKVARRILVVRDGAIPSDEIQTWISLAGQTPDLLPLLALSSIDTSPSLSFPSRASTSLTTIAGSDSQLGMYASPVSTPLANATSPELLSHVHTPGAVPAVSGDQHFDGDINARLVNTTDETWGVILAQPLNTAASLFEYRPALASGYLVKRAGPRDEDGLVSMGINLLHAPKPYHVQLKDVLDMFHGLGSLARIRGVVDPVKGILPWHMAMAVNARSGLDRML
Length1565
PositionKinase
OrganismUmbilicaria pustulata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Lecanoromycetes> OSLEUM clade> Umbilicariomycetidae> Umbilicariales> Umbilicariaceae> Lasallia.
Aromaticity0.07
Grand average of hydropathy-0.332
Instability index47.81
Isoelectric point5.12
Molecular weight170122.49
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13497
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     349.06|      93|     325|     847|     954|       2
---------------------------------------------------------------------------
  584-  680 (134.32/72.24)	PDVVTKEIPHDKHD..SY.EPLV.tdvhdITTTVEDMA..IG....R..MAP..SL.G....SSNNDEMNKSAAYkqapffnVQSRETKNGQAEVADILSPPQ.SPENSRKIVQPGF
  858-  954 (148.19/112.37)	PSLRTGYASDESDDalSYPEPSIL.....VSNSIQDFAIPIG....ELSMAPVKRLkD....SSTNIETLNDNDY.......VQLAQILADQLAFRDNAWPPTvASSDSYGILSTGY
 1206- 1271 (66.55/30.96)	..................PEGFIA.....SKETI...AMPLPaeyrRLAFEVYDRC..vpvaSERHVEMLNSAPA.......VQLAETLPRTIEFSLTAEP................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.07|      62|     326|     438|     506|       3
---------------------------------------------------------------------------
  438-  506 (94.82/64.14)	RAEREAAIeskrQEKELLAASKQA.ASVDDGEEDTSEIYSrtnQYID.AQAINGVYPTPPD.GFQPQAIGAT
  769-  833 (97.25/51.69)	RRKTEASI....QHGPCLATSDNTlAQTPRHPESSGENYS...TYSDtAEGENSYLDLHKDlSIKSPGTGET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.24|      27|      99|    1429|    1455|       4
---------------------------------------------------------------------------
 1429- 1455 (49.42/26.28)	LLSHVHTPGAVPAVSG..DQHFDGDINAR
 1530- 1558 (44.83/23.21)	LGSLARIRGVVDPVKGilPWHMAMAVNAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.04|      43|     229|     283|     326|       7
---------------------------------------------------------------------------
  283-  326 (76.57/38.04)	HTSDAFYGWEIrLA...P.....SSFPAKL.RAIESRSGSGTPAYDEAM.PDFD
  512-  564 (59.47/25.52)	RTSPAGHGASI.IAvdtPqgtqvAATPASMpRGFGLGSGSYVNNDDDDLfGDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      11|     229|    1179|    1189|      10
---------------------------------------------------------------------------
 1179- 1189 (21.83/12.69)	LGMFQAYVSAP
 1410- 1420 (22.09/12.93)	LGMYASPVSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.20|      39|     289|     681|     722|      11
---------------------------------------------------------------------------
  681-  722 (62.60/58.69)	RTSSAMGKDSTAQIGV..VKAPSAVGGRHHQHQRSlfdPVILSH
  971- 1011 (62.60/48.47)	RNSEQCDLKTYADIGLqtLEEPAVVKTVVRSDQRR...PTLPSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.83|      21|      22|     381|     402|      14
---------------------------------------------------------------------------
  381-  402 (35.04/25.75)	VQPGTVKTETILWPAAlCFFLD
  406-  426 (40.79/25.61)	VQSNTEHAAWLFRPME.DFFHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13497 with Med13 domain of Kingdom Fungi
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