<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13492

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGIQTTAISNMSQGGYATPQEGNRGGQISLAMLIDFIVQRTYHELTVLAELLPRKTDMERKIEIYSFAARTRQLFVRLLALVKWASSASKVEKSARIMAFLDKQSLLFVETADMLARMARETLVQARLPNFHIPAAVEVLTTGTYGRLPSCIRDRIVPPDPITNAEKRATLLRLNQVIQHRLVTGNLLPQMRNLKIENGRVTFHVEREFEVSLTVMGDGPNIPWRLLEIDILVEDKETGDGKVLVHPLQVQYIHQLIQARLVDNPLPLTEVYNCLHFFCQSLQLEVLYTQTLRLMRDRLDDHIHVDEYVPGRCLTISYWRELTTKGRDNSNKDLRSELGYKLSVQVDPHDSARPLSVQHVPSLGSKESEIADRAIRCELLSMERLLVHTIYVRTRSRLSDIKQELQGMLKDVECNLQGSPAILSVAILQPCLRAEQLLITVDTHTGMLQCQVPQYDAPLIPELQNSLNGDHARLPVLISELRYWITQRRCEKTLQHLPATAHERLPLLHYADHPLTKIGRHRMCVQLHRHPNVILIVELKEKENTSCEVGFSFYLAVVKQSSIEDNPNDDTIETEIPKSYLKVQSLIELDTFVVTHGPFTNVDEEIDTERNESSGLKRKTSTNKMECGTRRSKQPAYFISELAHVVAMCDERLPFITLTKELTNRSIFHQGLQVEANATGLVLRLIQLPPPTPEIGQSPAWQALLKRMLSVSIRVQSKGMQKSWMTEFVFYSSPLISSHPKEQGNRRPVYFQYDMGTIDTITRTVDSLLDDWYQIVHLYMIVHDLSEYLSSDKYNLSNMFSVKSYNYSKLILYYGQEKGAIVSINWNNSEKVFKLAFGANNNALNAHSLIREQLEAHLNQHRNLAQIIQLLNESYEPLISISKLPSLPQLGVYNTRPQVPVQTFTVMAQSCTLIRLAYQGMYCLELRLRGGGLVSLRDGAYSRYDRSNVVDVFTPTQGLKAFLSKYVDESAVFRRRSQSEDDNPPSPISMEVEGSGGFLGHHKGPQSPAQQRETGLRFHPPLTPPSGSNPHTPASPHTSNINQPSSHTNFGSSPATSFSLASPTSLPGNVNPSPLPVLPHPSPGSGLVANSPLNPHVPSPGGLLSNSSPGPSSTNLPGHSPGSSFMQQAGHSDGSPFPSSQSMTSPAASNWPGSPSVPRPSPARPGQSPGGPIMHSPQSDLKIGGHLSRVLPQRSWAGAVPTLLTHEALETLCCPSPHPQGLPGPELAPLERFLGCVFMRRQLQRFVHNENYLTALPMTEPGVIHFKVADTLQCRIGLNTQHLQSLHLKITPTPESKDVWNSEELQMIEKFFDSRAAAPPYKPISMFGFCCMLNVPVNILKDFVQIMRLDLMPQLCQQQGFKWSVQWMLRIPPSAIPIVPTGMAAVLVYRTKILFFLQITRIGVQYPNSMEPPSLVLPLVYDISTNITQLAEKRDAGPAPAMTAASQLLKHFAQFQSNHSECSLLPAVRELLMNLTLSSDPQQPSPAPGGVQQIQSPAMQMTQGGQPGYPVNIPMGMMGPQ
Length1527
PositionTail
OrganismAgrilus planipennis (Emerald ash borer) (Agrilus marcopoli)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Elateriformia> Buprestoidea> Buprestidae> Agrilinae> Agrilus.
Aromaticity0.07
Grand average of hydropathy-0.258
Instability index57.18
Isoelectric point7.94
Molecular weight170390.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.06|      18|      24|    1105|    1122|       1
---------------------------------------------------------------------------
 1059- 1072 (21.54/ 6.25)	SPATSF......SLASP....TSL
 1105- 1122 (35.99/15.96)	SPGGLL......SNSSPGPSSTNL
 1126- 1149 (23.99/ 7.89)	SPGSSFmqqaghSDGSPFPSSQSM
 1174- 1187 (25.53/ 8.93)	SPGGPI......MH.SP.QS..DL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.35|      35|      47|    1411|    1446|       2
---------------------------------------------------------------------------
 1411- 1446 (58.39/37.84)	QYPNSMEPPSLvLPLVYDISTNITQLAEKRDAGPAP
 1460- 1494 (62.95/36.88)	QFQSNHSECSL.LPAVRELLMNLTLSSDPQQPSPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.67|      15|     134|    1085|    1099|       3
---------------------------------------------------------------------------
 1014- 1028 (24.38/ 7.41)	PAQQRETGLRFHPPL
 1085- 1099 (32.29/12.20)	PHPSPGSGLVANSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      18|     134|      49|      69|       5
---------------------------------------------------------------------------
   49-   69 (22.35/26.58)	HELtVLAELLPRKTDMerKIE
  186-  203 (32.86/22.86)	HRL.VTGNLLPQMRNL..KIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.31|      15|      30|     469|     483|       6
---------------------------------------------------------------------------
  469-  483 (26.98/15.06)	LQNSLNGDHARLPVL
  500-  514 (27.33/15.35)	LQHLPATAHERLPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.38|      25|      70|    1208|    1232|       7
---------------------------------------------------------------------------
 1208- 1232 (48.85/26.11)	TLLTHEALETLCC....PSPHPQGL.....PGPE
 1268- 1301 (34.53/16.24)	GVIHFKVADTLQCriglNTQHLQSLhlkitPTPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.48|      24|      70|     137|     166|       8
---------------------------------------------------------------------------
  137-  165 (38.83/34.86)	FHIPAAVEVLTTGTYGRLPscirdRIVPP
  674-  697 (43.65/21.50)	FHQGLQVEANATGLVLRLI.....QLPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     149.29|      28|      65|     318|     345|      16
---------------------------------------------------------------------------
  254-  277 (23.52/10.17)	..............L.........QVQYIHQL..I.QARLVDN.PlPL.TEV
  278-  305 (20.00/ 7.49)	Y...........NCLhffcqslqlEVLYTQTL............R.LMRDRL
  317-  344 (47.34/28.27)	G...........RCL.........TISYWREL..TTKGRDNSN.K.DLRSEL
  345-  369 (36.41/19.97)	G...........YKL.........SVQV..DP..HDSARPLSV.Q.HVPS.L
  370-  411 (22.01/ 9.02)	GskeseiadraiRCE.........LLSMERLLvhTIYVRTRSRlS.DIKQEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.72|      13|      31|      70|      82|      18
---------------------------------------------------------------------------
   70-   82 (22.62/17.27)	IYSFAARTRQLFV
  103-  115 (22.10/16.67)	IMAFLDKQSLLFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.74|      31|      66|     786|     817|      20
---------------------------------------------------------------------------
  786-  817 (45.43/38.93)	MIVHDLSEYLSSDKyNLSNMFSVKSYNYSKLI
  818-  839 (34.73/22.92)	L.......YYGQEK...GAIVSINWNNSEKVF
  855-  885 (47.59/34.56)	LIREQLEAHLNQHR.NLAQIIQLLNESYEPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.55|       9|      27|     560|     570|      21
---------------------------------------------------------------------------
  560-  570 (11.87/14.08)	YLAVvkQSSIE
  586-  594 (16.68/10.65)	YLKV..QSLIE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13492 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPISMEVEGSGGFLGHHKGPQSPAQQRETGLRFHPPLTPPSGSNPHTPASPHTSNINQPSSHTNFGSSPATSFSLASPTSLPGNVNPSPLPVLPHPSPGSGLVANSPLNPHVPSPGGLLSNSSPGPSSTNLPGHSPGSSFMQQAGHSDGSPFPSSQSMTSPAASNWPGSPSVPRPSPARPGQSPGGPIMHSPQSDLKIGGHLS
2) LTLSSDPQQPSPAPGGVQQIQSPAMQMTQGGQPGYPVNIPMGMM
979
1481
1194
1524










Molecular Recognition Features






MoRF SequenceStartStop




NANANA