<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13489
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQQARDEKQLESALDAIIQRVNDLKTSISSMIYKIENEYETLSWPTFLDNFALISGQLTSLSKLLSHDKCPTLRNLTVLPLLLSPERDDQLAQLTEGRVTTFAHDLVPDYLRTKLEPSAESKMLNLEHKAATLAYENAQKQVAAYQKVVSHVWDIVNKAREEWEVESSARGSTQQNSSVADTHLLVAAVGMGKGLKMVNNPNNQTNQGNSMIVGSQGPGRPSGPPGQSNLPPSTQPMTMNKAPSAIKTNIKSATQIHPYGR |
Length | 261 |
Position | Head |
Organism | Agrilus planipennis (Emerald ash borer) (Agrilus marcopoli) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Coleoptera> Polyphaga> Elateriformia>
Buprestoidea> Buprestidae> Agrilinae> Agrilus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.503 |
Instability index | 33.21 |
Isoelectric point | 7.02 |
Molecular weight | 28719.17 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13489
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.66| 16| 16| 58| 73| 1
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58- 73 (28.25/15.71) LTSLSKLLSHDKCPTL
76- 91 (27.41/15.09) LTVLPLLLSPERDDQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.14| 11| 15| 208| 218| 2
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208- 218 (20.72/11.78) GNSMIVGSQGP
226- 236 (21.43/12.41) GQSNLPPSTQP
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