<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13487

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGIQTTAISNMSQGGYATPQEGNRGGQISLAMLIDFIVQRTYHELTVLAELLPRKTDMERKIEIYSFAARTRQLFVRLLALVKWASSASKVEKSARIMAFLDKQSLLFVETADMLARMARETLVQARLPNFHIPAAVEVLTTGTYGRLPSCIRDRIVPPDPITNAEKRATLLRLNQVIQHRLVTGNLLPQMRNLKIENGRVTFHVEREFEVSLTVMGDGPNIPWRLLEIDILVEDKETGDGKVLVHPLQVQYIHQLIQARLVDNPLPLTEVYNCLHFFCQSLQLEVLYTQTLRLMRDRLDDHIHVDEYVPGRCLTISYWRELTTKGRDNSNKDLRSELGYKLSVQVDPHDSARPLSVQHVPSLGSKESEIADRAIRCELLSMERLLVHTIYVRTRSRLSDIKQELQGMLKDVECNLQGSPAILSVAILQPCLRAEQLLITVDTHTGMLQCQVPQYDAPLIPELQNSLNGDHARLPVLISELRYWITQRRCEKTLQHLPATAHERLPLLHYADHPLTKIGRHRMCVQLHRHPNVILIVELKEKENTSCEVGFSFYLAVVKQSSIEDNPNDDTIETEIPKSYLKVQSLIELDTFVVTHGPFTNVDEEIDTERNESSGLKRKTSTNKMECGTRRSKQPAYFISELAHVVAMCDERLPFITLTKELTNRSIFHQGLQVEANATGLVLRLIQLPPPTPEIGQSPAWQALLKRMLSVSIRVQSKGMQKSWMTEFVFYSSPLISSHPKEQGNRRPVYFQYDMGTIDTITRTVDSLLDDWYQIVHLYMIVHDLSEYLSSDKYNLSNMFSVKSYNYSKLILYYGQEKGAIVSINWNNSEKVFKLAFGANNNALNAHSLIREQLEAHLNQHRNLAQIIQLLNESYEPLISISKLPSLPQLGVYNTQRPQVPVQTFTVMAQSCTLIRLAYQGMYCLELRLRGGGLVSLRDGAYSRYDRSNVVDVFTPTQGLKAFLSKYVDESAVFRRRSQSEDDNPPSPISMEVEGSGGFLGHHKGPQSPAQQRETGLRFHPPLTPPSGSNPHTPASPHTSNINQPSSHTNFGSSPATSFSLASPTSLPGNVNPSPLPVLPHPSPGSGLVANSPLNPHVPSPGGLLSNSSPGPSSTNLPGHSPGSSFMQQAGHSDGSPFPSSQSMTSPAASNWPGSPSVPRPSPARPGQSPGGPIMHSPQSDLKIGGHLSRVLPQRSWAGAVPTLLTHEALETLCCPSPHPQGLPGPELAPLERFLGCVFMRRQLQRFVHNENYLTALPMTEPGVIHFKVADTLQCRIGLNTQHLQSLHLKITPTPESKDVWNSEELQMIEKFFDSRAAAPPYKPISMFGFCCMLNVPVNILKDFVQIMRLDLMPQLCQQQGFKWSVQWMLRIPPSAIPIVPTGMAAVLVYRTKILFFLQITRIGVQYPNSMEPPSLVLPLVYDISTNITQLAEKRDAGPAPAMTAASQLLKHFAQFQSNHSECSLLPAVRELLMNLTLSSDPQQPSPAPGGVQQIQSPAMQMTQGGQPGYPVNIPMGMMGPQ
Length1528
PositionTail
OrganismAgrilus planipennis (Emerald ash borer) (Agrilus marcopoli)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Elateriformia> Buprestoidea> Buprestidae> Agrilinae> Agrilus.
Aromaticity0.07
Grand average of hydropathy-0.260
Instability index57.10
Isoelectric point7.94
Molecular weight170518.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13487
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     358.62|      58|      64|    1026|    1083|       1
---------------------------------------------------------------------------
  984- 1024 (54.49/15.31)	.........SQS......EDDNPP.SPI..SMEVE..........GSG.....GFLGHH.KGPQS.PAQQ.....RETGLR
 1026- 1083 (111.54/37.45)	HPPLTP..PSGS......NPHTPA.SPH..TSNINQ.PSSHTNF.GSS.....PATSFSLASPTSLPGNV.....NPSPLP
 1087- 1145 (71.54/21.93)	HP..SP..GSGLvansplNPHVP..SPGglLSNSSPgPSS.TNLpGHS.....PGSSF.....MQQAGHS.....DGSPFP
 1157- 1226 (86.11/27.58)	NWPGSPsvPRPS.......PARPGqSPG..GPIMHS.PQSDLKI.GGHlsrvlPQRSWAGAVPTLLTHEAletlcCPSPHP
 1488- 1515 (34.94/ 7.72)	..PQQP.....S.......PA.PG...G..VQQIQS.PAMQMTQ.GGQ.....PG..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      18|     134|      49|      69|       2
---------------------------------------------------------------------------
   49-   69 (22.35/21.57)	HELtVLAELLPRKTDMerKIE
  186-  203 (32.86/18.52)	HRL.VTGNLLPQMRNL..KIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.55|       9|      23|     560|     570|       4
---------------------------------------------------------------------------
  560-  570 (11.87/12.86)	YLAVvkQSSIE
  586-  594 (16.68/ 9.74)	YLKV..QSLIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.72|      52|      66|     318|     369|       5
---------------------------------------------------------------------------
  318-  366 (77.28/49.99)	...................RCLTISYWREL..TTKGRDNSN.KD.LR.SEL.GYKLSVQVDPHDSARPLSVQHV
  367-  434 (58.70/35.98)	PSL....gskeseiadraiRCELLSMERLLvhTIYVRTRSRlSD.IK.QELqGMLKDVECNLQGSPAILSVAIL
  436-  503 (63.74/39.77)	PCLraeqllitvdthtgmlQCQVPQYDAPL..IPELQNSLN.GDhARlPVL.ISELRYWITQRRCEKTL..QHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.08|      21|      24|     805|     827|       6
---------------------------------------------------------------------------
  807-  827 (35.89/29.70)	SVKSYNYSKLI.LYYGQEKGAI
  829-  850 (32.19/17.57)	SINWNNSEKVFkLAFGANNNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.80|      52|      62|    1244|    1299|       7
---------------------------------------------------------------------------
 1244- 1299 (80.51/57.94)	VFMRRQLQRFvhnENYL...TALPMTEPgVIHFKVADTLQCRIGLNTQHLQSLHLKITP
 1306- 1360 (89.29/52.00)	VWNSEELQMI...EKFFdsrAAAPPYKP.ISMFGFCCMLNVPVNILKDFVQIMRLDLMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.42|      23|      47|    1412|    1435|       8
---------------------------------------------------------------------------
 1412- 1435 (37.75/28.79)	QYPNSMEPPSLvLPLVYDISTNIT
 1461- 1483 (40.67/26.23)	QFQSNHSECSL.LPAVRELLMNLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13487 with Med14 domain of Kingdom Metazoa
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