<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13479

Description mediator of RNA polymerase II transcription subunit 25
SequenceMEVDQMPLADVVFIIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERYATLYGIVVYRTAANLLEPVCTTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDLSERRQLLDQTNVQRHCILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPILFKLFMKADGDQPITSKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQAAVQQQQQQQNAAGQQQAGQGMPMDTTPAQQQQQQQQQQQQGNPQQQVMNMNSMQQQQTGPNPQAGHLNPQQQQQLLQQQQQQQQQQQQQQQNQFVPNQMQNPNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQVQQQQQQRMLLSQQQMLNHQQLQQQQQMAQQQQQQGQQQQQVNPNAGNNMMPAGNAGNMPNPQQQQVGQQANPQQQGNPQQQQANPQQEQASLREKIWTGILEWSEKPKSDPQKIPHSLQCTVCTNIKDGQPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPSPGEALDSLAKMMTSGYAGCVHFSSIPNAPACDLKVLILLYTPDRNAFLGFIPNNQAIFVERLRKVIQQKQHGSMQQQQQQQQMMQQQGKSPMELQQQQQQQMQQDNSQQQHYNQYQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGSYEFM
Length850
PositionUnknown
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.889
Instability index63.88
Isoelectric point8.85
Molecular weight95056.17
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13479
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.68|      23|      26|     233|     258|       2
---------------------------------------------------------------------------
  294-  316 (44.21/ 6.22)	SMQQQQTGPNPQAGHLNPQQQQQ
  679-  701 (36.47/ 7.04)	MMQQQGKSPMELQQQQQQQMQQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.63|      23|      26|     709|     734|       3
---------------------------------------------------------------------------
  709-  732 (40.06/ 8.34)	NQYQLNMQMGGGGPgGGPGPGPGG
  738-  760 (38.57/ 7.31)	NQMQMNMMQQQRMP.LGVGVGPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.48|      33|      40|     763|     801|       6
---------------------------------------------------------------------------
  763-  800 (55.30/15.94)	NPNLQQQL...QQVAPNvaaMQQQQAQQQQQRmvRPMMSNN
  805-  840 (57.18/10.97)	RQLLQHQTtpgNQFRPQ...MGGQNPNQMGAG..GPMVGNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     231.51|      38|      38|     496|     533|      11
---------------------------------------------------------------------------
  338-  368 (48.41/17.46)	.PNQMQ..NP......NFQ..........Q.....NVGPGQNRWMYPN...QPG....QARP.
  369-  404 (33.14/ 8.69)	.PFMQGagNVggvgqgGGM..........Q....QNPNSAL..ISRIN...APP.......PN
  496-  533 (66.20/27.68)	NPQQQG..NP......QQQ..........Q....ANPQQEQASLREKI...WTGILEWSEKPK
  535-  574 (51.72/19.36)	DPQKI....P......HSL..........QctvcTNIKDGQPEIKAEN...WPPKLLMQLMPK
  578-  623 (32.05/ 8.06)	.....G..NI......GGQflkdskmvvfR....PSPGEALDSLAKMMtsgYAGCVHFSSIPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.14|      80|     114|      32|     114|      12
---------------------------------------------------------------------------
   32-  114 (130.55/92.73)	YILPTLE..HFTTGSIDEREYLIAERYATLyGIVVYRTAANLLEPVCTTYGPflQP...QKVMETIERLPLVGG.GMESCAHMAEGFAA
  147-  232 (124.59/77.91)	YQMPTTEswKYPGKSCEQLAALFNERKINL.SIIAPRKMPILFKLFMKADGD..QPitsKNYAKNIRHLVLLKGySLKERAPSPNSMAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13479 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KGYSLKERAPSPNSMAAQMAAPNAAQAAVQQQQQQQNAAGQQQAGQGMPMDTTPAQQQQQQQQQQQQGNPQQQVMNMNSMQQQQTGPNPQAGHLNPQQQQQLLQQQQQQQQQQQQQQQNQFVPNQMQNPNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQVQQQQQQRMLLSQQQMLNHQQLQQQQQMAQQQQQQGQQQQQVNPNAGNNMMPAGNAGNMPNPQQQQVGQQANPQQQGNPQQQQANPQQEQASLREKIWTGILEWSEKPKSDPQKIPHSLQCT
2) QKQHGSMQQQQQQQQMMQQQGKSPMELQQQQQQQMQQDNSQQQHYNQYQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGSYEFM
216
664
546
850










Molecular Recognition Features






MoRF SequenceStartStop




NANANA