<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13478

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMNMQQFAQNPNNMMQPNAMMQQQQHMQQMNNNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGAGPSGMPGQQQQWHNAQQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNSNSKQALSQMLRQRQPFQQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQMPQNMVGMVNPNANQMMQAGGAQGGNGVGVGVGVGVGVGGAGNNPNIGMGGMPQQGIMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQQGMQQQGGGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAVAAAAQQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSNMMGPGPGGVVGQVPPYARQQPAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGSGPQQPGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQPPPY
Length543
PositionKinase
OrganismDrosophila ficusphila (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-1.238
Instability index71.99
Isoelectric point11.52
Molecular weight59158.14
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13478
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     404.42|      66|      66|     221|     286|       1
---------------------------------------------------------------------------
  163-  219 (86.14/ 9.33)	NQMRQQQMNPQQNPQsvaafNA.MQQQQ...QQNaQQQQMN.PNQQQ..QQQFMRG..GN........MR.P.G..M...A
  221-  286 (137.47/23.22)	NQMNQMNMGGQGMPQ.....NPMMQQQM...PQN.MVGMVN.PNANQMMQAGGAQG..GNGVG...VGVGVGVGVGGAGNN
  288-  353 (100.12/13.12)	N....IGMGG..MPQ.....QGIMQQQPqqqPQQ.QVQFQNfQNQYQQQQQQQQQGmqQQGGG...GGVGVGVGVGMAPNQ
  457-  508 (80.70/ 7.86)	QQFQQQQQQQQQLRH.....QQMMQMQ..........GM...........GGGAGG..GMGSGpqqPGGAVG.GGGGGGMV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.10|      44|      47|       8|      54|       3
---------------------------------------------------------------------------
    8-   54 (82.80/17.96)	QNP.NNMMQPNAMMQQQqhmQQMNNNPLQQQLNVGGG..N....GQQNPQMNFM
   56-  104 (74.07/11.63)	QGPgGGGAGPSGMPGQQ...QQWHNAQQQQQPPQPYH..NqyapHQQNMQSNRI
  374-  414 (59.22/ 6.90)	RNN.PDFMAVAAAAQQQ....QQQ..QQQQQRVVPGGmmA....GNRNQYMN..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      18|      19|     415|     432|       5
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  415-  432 (35.28/12.40)	QAPNVTMSNMMGPGPGGV
  435-  452 (34.90/12.18)	QVPPYARQQPAGGGKPGV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.39|      13|     167|     355|     371|       8
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  355-  371 (21.59/12.24)	QQQQANMMGnfnpQMQQ
  525-  537 (26.80/ 6.57)	QLQRQNMMG....QQQQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13478 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGAGNNPNIGMGGMPQQGIMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQQGMQQQGGGGGVGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAVAAAAQQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSNMMGPGPGGVVGQVPPYARQQPAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGSGPQQPGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQPPPY
2) MNMQQFAQNPNNMMQPNAMMQQQQHMQQMNNNPLQQQLNVGGGNGQQNPQMNFMQQGPGGGGAGPSGMPGQQQQWHNAQQQQQPPQPYHNQYAPHQQNMQSNRIERPPLNSNSKQALSQMLRQRQPFQQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQMNPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQMPQNMVGMVNPNANQMMQAGGAQG
281
1
543
266










Molecular Recognition Features






MoRF SequenceStartStop




1) QYQPPPY
537
543